It's because nobody else is reading your shit so you have to keep the equilibrium. Yin and Yang.
I get jacked off, but I get hard again, you're never gonna keep me soft
2016-03-01 at 12:59 AM UTC
in
Can Bernie beat Hillary?
Trump will win and Democrats will never recovery
2016-03-01 at 12:56 AM UTC
in
Parallel Universe Theory
Black holes are clearly portals to alternate universes
The key to super bundy is through DXO. I'm thinking there must be a way to make it so you consume ONE pill and in your liver it becomes a 2 or 3 gram dose of DXO.
[FONT=verdana]Another class of sigma ligand that shows some odd dissociative effects is N-allyl-normetazocine and pentazocine (Talwin?). These compounds are also partial mu agoninsts and are (were) used as narcotics with supposed low abuse profiles for opiate fans. But in higher dosage ranges they can cause bizarre hallucinogenic effects. [/FONT]
Table 4: 3-Substituted bundy Analogs 3-Position Substitution IC50 [3H]bundy IC50 [3H]TCP ED50 Rats % Rats OCH3 (bundy) 0.59M (0.12) 2.0M (0.6) 38mg/kg 70 OH (dextrorphan) 7.7M (0.9) 1.2M (0.7) 5mg/kg 90 NH2 45% at 10M 7.8M (1.4) 25mg/kg 100 NHCH3 3.6M (1.4) 43% at 10M 0 N(CH3)2 4.4M (0.9) 45% at 10M 40mg/kg 40 Cl 1.1M (0.4) 5.5M (1.5) 10 NCS 1.5M (0.3) 60% at 10M 0 H (i.e., nothing) 1.3M (0.3) 53% at 10M 0 O-Et (ethyl) 0.42M (0.06) 75% at 10M 5.6mg/kg 90 O-2-Pr (2-propyl) 0.88M (0.18) 59% at 10M 3.9mg/kg 90 O-n-Bu (n-butyl) 1.5M (0.4) 58% at 10M 40 O-Bz (benzyl) 3.1M (0.6) 39% at 10M 30
We previously demonstrated that dextromethorphan (DM; 3-methoxy-17-methylmorphinan) analogs have neuroprotective effects, and a recent report showed that DM reduces the adverse effects of morphine and blocks a3b4 nicotinic acetylcholine receptors, a major target of anti-addictive agents. Here, we investigated the effects of DM, three of its analogs (DF, 3-methyl-17-methylmorphinan; AM, 3-allyloxy-17-methoxymorphian; and CM, 3-cyclopropyl-17-methoxymorphinan) and one of its metabolites (HM; 3-methoxymorphinan), on neuronal a3b4 nicotinic acetylcholine receptor channel activity expressed in Xenopus laevis oocytes, using the two-microelectrode voltage clamp technique. We found that intraoocyte injection of neuronal a3 and b4 nicotinic acetylcholine receptor subunit cRNAs elicited an inward current (I ACh) in the presence of acetylcholine. Co-treatment with DM, DF, AM, CM or HM inhibited I ACh in a dose-dependent, voltage-independent and reversible manner. The IC50 values for DM, DF, AM, CM and HM were 19.5 ± 5.2, 15.8 ± 4.5, 16.3 ± 1.7, 10.1±2.8, and 13.5 ± 4.0 mM, resp. The order of potency for the inhibition of IACh was CM > HM > DF = AM > DM in oocytes expressing a3b4 nicotinic acetylcholine receptors. The inhibitions of (I ACh) by DM, DF and HM, AM and CM were non-competitive. These results indicate that AM, CM and HM could be novel non-competitive agents regulating a3b4 nicotinic acetylcholine receptor channel activity.
2016-03-01 at 12:32 AM UTC
in
Games We've Completed
ODs are for the birds. If your H ain't little brown pebbles or some BTH your getting sold fentanyl and vitamin powder
I'm waiting for dissociater to chop and screw it
2016-02-29 at 9:29 PM UTC
in
Games We've Completed
well of course theres always the possibility of impurities. do you think thats what did it though? i mean ive known a lot of people who have used a lot of opiates and other drugs and just never known someone to have a stroke, although i always knew it was within the realm of possibility. but i thought it came mostly from coke/meth.
the only bigger faggot on this site than Bill Krozby is captain falcon
2016-02-29 at 8:02 PM UTC
in
Any plans to fix this site?
There needs to be a chatbox with an uplink to a laser on a tripod that can be controlled with buttons by anyone in the chatbox with a GoPro or webcam attached and pointed towards the sky and we try and scout for planes and if two more people click the fire button within 1 second it will fire the laser out of the window and we can try and shoot down planes and shit.
AND ILL NEVER HAVE THAT RECIPE AGAIN
