Posts by The Self Taught Man

1. 2017-01-15 at 11:47 AM UTC in scranaldo j trump
   The Self Taught Man Black Hole
   Yeah that guy is nothing but black hole of setting structures on fire and murdering your entire family.
2. 2017-01-15 at 11:44 AM UTC in I don't impress Lanny
   The Self Taught Man Black Hole
   Your all lucky I post here.
3. 2017-01-15 at 11:44 AM UTC in ITS 17 DONT BE ALARMED
   The Self Taught Man Black Hole
   ^^
4. 2017-01-15 at 11:43 AM UTC in ITS 17 DONT BE ALARMED
   The Self Taught Man Black Hole
   ^
5. 2017-01-15 at 11:43 AM UTC in The plight of the schizophrenic
   The Self Taught Man Black Hole
   You should be an orderly
6. 2017-01-15 at 11:40 AM UTC in The retarded thread: Fuck, §m£ÂgØL made one first edition
   The Self Taught Man Black Hole
   I used to huff menthol
7. 2017-01-15 at 11:39 AM UTC in The retarded thread: Fuck, §m£ÂgØL made one first edition
   The Self Taught Man Black Hole
   WHERE IS MY TECH REEEEEEE
8. 2017-01-15 at 11:39 AM UTC in i am smarter than god
   The Self Taught Man Black Hole
   God aint real that means your retarded lololol
9. 2017-01-15 at 11:38 AM UTC in computer fucking up badly, what do?
   The Self Taught Man Black Hole
   Get a can of duster and huff that shit straight to the dome son
10. 2017-01-15 at 9:05 AM UTC in The retarded thread: Fuck, §m£ÂgØL made one first edition
    The Self Taught Man Black Hole

    Prolonged cigarette smoking is associated with an increase in nACh receptor density throughout the brain (Picciotto and Kenny, 2013). This process of receptor “up-regulation” is likely to play an important role in the physiological underpinnings of nicotine addiction.

    
    so menthol upregulates the same way nicotine does, through desensitization and rebound effect. from what i can tell menthol inhibits nicotinic signaling so it actually doesn't potentiate the effects, but instead causes long term changes in the receptor which contribute to addiction. does chronic nicotine administration benefit people? my common sense would say no, but who knows, maybe people who vape pure nicotine constantly are slightly mentally sharper. another interesting thing to consider is that if you use enough menthol to upregulate your nicotine receptors, you could get possibly end up habituating menthol the same way people habituate nicotine.
11. 2017-01-15 at 8:53 AM UTC in The retarded thread: Fuck, §m£ÂgØL made one first edition
    The Self Taught Man Black Hole
    that sounds awful
    
    i bet it would be more pleasant sucking on x quantity of ricola every day
    
    i've also read that menthol potentiates the nicotine but i don't know if its due to receptor upregulation. too lazy to google right now.
    
    and what does increased nicotinic receptor expression translate to? enhanced acetylcholine function? what benefits would this theoretically have?
    
    if this actually makes sense it'll be a new reddit thing to add coughdrop bundies to their stacks
    
    menthol has other pharmacological and probably minor properties like enhancing GABAA currents as a positve allosteric modulator
    
    Post last edited by the holy ghost at 2017-01-15T08:56:55.574787+00:00
12. 2017-01-15 at 8:45 AM UTC in The plight of the schizophrenic
    The Self Taught Man Black Hole

    Originally posted by Lanny using "E.Q." unironically

    
    cognitive empathy and emotional empathy are valid constructs
    
    E.Q. conflates the two and is used as a cop out for people who like to feel better about themselves
    
    also all E.Q. measures are just self report questionnaires like "I am a people person TRUE FALSE" which is sort of like saying an IQ test is "I am smart YES NO"
13. 2017-01-15 at 8:36 AM UTC in Don't ever get married
    The Self Taught Man Black Hole
    shes fucking another man
14. 2017-01-15 at 8:31 AM UTC in The plight of the schizophrenic
    The Self Taught Man Black Hole
    i'm not a self proclaimed autist you literally are. you've said so multiple times. you tell us about all the girls you bang but it turns out they're just pictures you found on the internet.
15. 2017-01-15 at 8:30 AM UTC in i am smarter than the whole supermultiverse
    The Self Taught Man Black Hole
    all inanimate objects are one and i am two
    
    get it???
16. 2017-01-15 at 8:29 AM UTC in i am smarter than god
    The Self Taught Man Black Hole
    he's a very illogical person
17. 2017-01-15 at 8:28 AM UTC in i am the smartest sentient being to ever exist in an infinite timespan
    The Self Taught Man Black Hole
    i think therefore i am sam
18. 2017-01-15 at 8:27 AM UTC in i am the smartest person in the world
    The Self Taught Man Black Hole
    the science i created confirms this
    
    Post last edited by the holy ghost at 2017-01-15T08:32:53.511682+00:00
19. 2017-01-15 at 8:23 AM UTC in i am the smartest person on this website
    The Self Taught Man Black Hole
    or at least in top 3
20. 2017-01-15 at 8:05 AM UTC in The retarded thread: Fuck, §m£ÂgØL made one first edition
    The Self Taught Man Black Hole

    Originally posted by Malice IIRC menthol actually considerably upregulates nicotinic receptors.

    
    does that mean i can use menthol cough drops and vaporub as a cognitive enhancer??????/