I plan to do drugs in the future. I have always been able to keep the lights on and keep the drugs and money coming in one way or another so it just doesn't seem like a problem to me. I need to work 24/7 to keep busy or I will spend all my money on drugs and booze out of boredom. I don't get bored if i'm working and getting paid so I just need to orient my life to do that all the time
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Trianglists have been worshipping gut CYP3A for generations
Originally posted by frumbob 🐎🦄🐈🐯🐷🦊
it does cross the blood brain barrier. the bio-availability of loperamide is 0.3%, only a percent of that 0.3% is able to make it past the BBB, and then p-glycoprotein in the brain pushes it back out, so you end up with very minute quantities able to stay in the brain, but since once in the brain it has around the potency of fentanyl, that is not a huge issue, as long as you take like 200mg+, and use p-glycoprotein inhibitors/ cyp3a liver enzyme inducers. im scratching my skin off rn and was almost nodding for 20 minutes so it definitely works, but i dont really consider it to be a worthwhile buzz
i've also heard of someone injecting mannitol, which opens the BBB for a 10 minute time frame, and then injecting lope, and having it hit with a full effect
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I've mixed ⅅXM with every class of drugs, none of it was good. The only thing you can do is eat 4-8 benadryl and chug a grapefruit juice. There are no good drugs to mix it with and any of them will take away from a good pure bundy trip
Antihistamines - Many H1 antagonists, including antihistamines such Benadryl or terfenadine, as well as many antipsychotics, can slow down the metabolism of bundy due to their inhibition of CYP2D6, leading to possible death.
CHUG GRAPEFRUIT AND BEEEDRILL IT GETS YOU HIGHER!!!!
https://www.sciencedirect.com/science/article/abs/pii/S002432050201799X?via%3DihubThe effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein
it's not even fun to smoke weed while tripping on a high dose you don't even feel it and maybe it might make you puke less.
Originally posted by Crispy
Will i die
maybe
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POLECAT
POLECAT is a motherfucking ferret
[my presentably immunised ammonification]
Originally posted by Crispy
Shut up whore, slutbag, cumdump
please respect your elders,
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Instigator
Naturally Camouflaged
[the staring tame crusher]
Today I will travelling to go and live in West Philadelphia born and raised
On the playground was where I spent most of my days
Chillin' out, maxin', relaxin', all cool
And all shootin' some b-ball outside of the school
When a couple of guys who were up to no good
Started making trouble in my neighborhood
I got in one little fight and my mom got scared
She said, "You're movin' with your auntie and uncle in Bel-Air"
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Originally posted by ⠀⠀⠀⠀⠀⠀
In Canada, a lot of poor people become very depressed and suicidal around Christmas time, so they reach out to government help services, and the help services direct them to the MAID program, where they are offered an assisted suicide to end it all. If the person agrees, after much coaxing by the MAID official, the person is then immediately picked up and transported to the MAID lab, where the person is put to sleep that same day they called in. MAID, which is run by third-part providers, then bill the taxpayer for their services to the tune of $27,000 per client.
I wish I was in Canada
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I think some shoes would be cool to
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Fonaplats
victim of incest
[daylong jump-start that nome]
I already have a gift for all of you. You'll get it and when you do it will bring peace to NIS.
prepare for it now.
Rependt
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Originally posted by RisiR †
Just the first word of this. If it's achieved through peace will be found out soon.
We already got the first part idiot
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"Whenever it is that they are saying, 'Peace and security!' then sudden destruction is to be instantly on them, just like birth pains on a pregnant woman, and they will by no means escape." - 1 Thessalonians 5:3
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Originally posted by What_a_Kreep
More than your mom but less than my self-esteem.
I don't have a mother. I wasn't born. I'm like an orphan from the getgo.
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Grimace
motherfucker
[my enumerable hindi guideword]
Originally posted by ner vegas
less drugs, less stability, feel myself slipping slowly into WOZNY MODE
funny how that is
Not the wozny mode!
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2024-11-14 at 12:15 AM UTC
in
Word of the day
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Originally posted by Fax 📠
I was in an extremely toxic relationship at the time. But that's everyone, right.
no, some people are smart enough to get a pet
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2024-11-13 at 10:08 PM UTC
in
What do you want for Crispmas?
I'd like for all my friends and family to be happy!
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World peace and for all the little children to go to bed with full bellies (of food before the pedos say semen)
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What do you want on this oh so special day?
Even if you aren’t getting what you want because you were naughty, say what you’d want.
I personally want a lot of cigarettes and a dinosaur, a real life dinosaur. A Kosmoceratops maybe. I’d have to build a house for it, and sew clothes for it so it doesn’t get bullied at school
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Worshipping triangles. Triangles are the creme de la creme of polygons.
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Originally posted by Crispy
I wish the fbi would take me and put me in a facility and give me medications so i dont have to think, too bad
Lay on your belly and we'll send someone around in about 10 minutes.
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