User Controls
The Retarded Thread: Get Rekt, Faggot!
-
2018-01-05 at 5:13 AM UTC
-
2018-01-05 at 5:16 AM UTC
-
2018-01-05 at 5:16 AM UTC
Originally posted by Fromus Krokus CYP450 literally metabolizes like everything ever
your liver enzymes getting depleted doesn't potentiate it you fucking idiot, if anything, the fact that your body can't metabolize the chemical since the enzymes are occupied means it will have either a reduced or longer effect, not stronger. the reason its stronger when mixing GABA drugs is because when the GABA drugs dont work on the same subunit, they have a multiplicative rather than additive effect because the GABA cell is like WTF
You realize your body can still process the drug unmetabolized, right? By your logic, there should be no such thing as an overdose since drugs would get weaker the speed and amount at which you consume. Obviously they aren't all the same, but in the case of alcohol and most opiates it is, and they get stronger because the body is better at handling things like morphine and acetyldehyde than it is hydromorphone and ethanol. -
2018-01-05 at 5:18 AM UTC
Originally posted by Fromus Krokus i drank a cup of coffee so now i cant have a beer… muh CYP450 ='(
Maybe if you ever had real drugs you wouldn't laugh. The real niggas (like me, I'm a realer niggerer than you will ever be) simply practice moderation over abstinence. This is why I get laid and you get lies. -
2018-01-05 at 5:20 AM UTC
Originally posted by 哈哈你看不懂中文 You realize your body can still process the drug unmetabolized, right? By your logic, there should be no such thing as an overdose since drugs would get weaker the speed and amount at which you consume. Obviously they aren't all the same, but in the case of alcohol and most opiates it is, and they get stronger because the body is better at handling things like morphine and acetyldehyde than it is hydromorphone and ethanol.
of course, thats why i said longer. its not going to get any stronger than it is when it first peaks, but the peak might be drawn out if your body can't metabolize it right way. the fact that practically every drug ever made gets metabolized to some extent by CYP450 means the main reason people would get an overdose is not because of CYP450, whether the other chemical is a depressant or not. not that it will have no effect, but it is negligible compared to just the fact that drugs working on the same receptor will act multiplicatively in neurotransmission, or that drugs that both produce respiratory depression will act multiplicatively in neurotransmission -
2018-01-05 at 5:22 AM UTC
-
2018-01-05 at 5:23 AM UTCquestion: if neither the opiate nor the benzo were cyp450 substrates, would combining the two still potentially cause an overdose?
answer: no shit lol -
2018-01-05 at 5:26 AM UTCif a user injects a substance, they basically reach the peak plasma of both substances instantly, so any metabolism would occur after the rush
HMMM I WONDER IF I INJECT 60MG OF OXY AND 5MG OF XANAX IM MORE LIKELY TO DIE IMMEDIATELY THAN IF I JUST SHOOT THE OXY -
2018-01-05 at 5:27 AM UTC
Originally posted by Fromus Krokus of course, thats why i said longer. its not going to get any stronger than it is when it first peaks, but the peak might be drawn out if your body can't metabolize it right way. the fact that practically every drug ever made gets metabolized to some extent by CYP450 means the main reason people would get an overdose is not because of CYP450, whether the other chemical is a depressant or not. not that it will have no effect, but it is negligible compared to just the fact that drugs working on the same receptor will act multiplicatively in neurotransmission, or that drugs that both produce respiratory depression will act multiplicatively in neurotransmission
What is your explanation for potentiation then? What is it that has caused me to take opiates and phenibut and get absolutely piss drunk on the floor hammered with a measly 5 beers, when the same 5 beers leaves me mostly unsatisfied at any other time?
-
2018-01-05 at 5:27 AM UTCWhat are people usually prescribed gabapentin for?
-
2018-01-05 at 5:28 AM UTC
-
2018-01-05 at 5:29 AM UTC
Originally posted by Fromus Krokus if a user injects a substance, they basically reach the peak plasma of both substances instantly, so any metabolism would occur after the rush
HMMM I WONDER IF I INJECT 60MG OF OXY AND 5MG OF XANAX IM MORE LIKELY TO DIE IMMEDIATELY THAN IF I JUST SHOOT THE OXY
Pretty specific -
2018-01-05 at 5:30 AM UTC
Originally posted by Fromus Krokus learn to use the fucking search engine
neuropathic pain or epilepsy, but really they prescribe it for anything since there was a big off-label marketing scandal
I just said I'm asking here first to allow you to flex your eEgo. Please calm down. Maybe you need some gabapentin. -
2018-01-05 at 5:30 AM UTC
-
2018-01-05 at 5:38 AM UTC
Originally posted by 哈哈你看不懂中文 If it's dosed accurately. I heard most street tabs are more like ~70-80ug
not street tabs golm. check it out for yourself.
http://t3e6ly3uoif4zcw2.onion.gold/viewProduct?offer=650936.688709
sign in with
un = §m£ÂgØL
pw = smeagle678
. -
2018-01-05 at 5:39 AM UTC
Originally posted by Fromus Krokus try only potentiating using inhibitors like white grapefruit juice or tonic water. the degree of potentiation is mild at most in my experience, using only p450 substrates that are not on their own psychoactive
Are you honestly comparing grapefruit juice to morphine here? Tell me sploo, what is the hardest you've ever gone on CYP450 usin' droogs. -
2018-01-05 at 5:41 AM UTC
Originally posted by NARCassist not street tabs golm. check it out for yourself.
http://t3e6ly3uoif4zcw2.onion.gold/viewProduct?offer=650936.688709
sign in with
un = §m£ÂgØL
pw = smeagle678
.
Darknet tabs = street tabs. Pretty regular to see reviews that are talking about how they are weaker than advertised. Usually that is not a negative thing, since it's basically to be expected. I mean I dunno, I feel like analogue tabs are typically way stronger than LSD. The tabs I've had off dnm and off the street have been of similar quality. -
2018-01-05 at 5:42 AM UTC
Originally posted by 哈哈你看不懂中文 Are you honestly comparing grapefruit juice to morphine here? Tell me sploo, what is the hardest you've ever gone on CYP450 usin' droogs.
no, im not
most likely, grapefruit juice is a stronger inhibitor of p450 than morphine, that doesn't mean it isn't placebo otherwise
but the point is, if you're saying the potentiation through p450 can only happen when both of the substances are psychoactive/powerful narcotics, it becomes impossible to determine how much of the potentiation is due to p450 or just getting fucked up on 2 different drugs at once which then basically function as one drug in the brain. the only way to test for this is to compare to an equally dosed combo that doesnt effect p450 -
2018-01-05 at 5:49 AM UTCI'm not basing it off that. I am basing it off my own personal experience where I've woken up liek "welp, all those drugs have worn off. Lets have a morning beer" and then that beer gets me way drunker for breakfast than I'd have liked. What else should I attribute it to but enzyme deficiency? Seems like it's always a downwards slope for me when I binge, until ultimately I have to take a break. This has mostly been when I'm combining multiple drugs. Had a period where opiates/benzos/phenibut/alcohol were my breakfast lunch and dinner and it was pretty ugly.
I don't know that there are any studies about how strong the potentiation from decreased metabolization works on the drugs we're discussing is, and I'm too lazy to find them myself if there are, but if you're feeling autistic you should do it. Or one about the multiplicative effects would be cool too. But this is kinda oddly specific. -
2018-01-05 at 5:49 AM UTCOh god, my brain still feels off, somewhat fried, from all that shit that happened to me. I'm pretty sure they hit me a sedative and anti-psychotic on the first day I entered the psych ward. I have a memory of using a judo I had seen on youtube and knocking two of the staff on their ass, them needing every single person there to restrain me and inject me in both shoulders.
Heh, I sure as hell had good reasons for freaking out. I'm proud of myself for putting up a fight. I didn't take swings at them because I wasn't interested in actually harming them, and it's a good thing I didn't because I could have received multiple assault charges.
That shit made me delirious for a long time. I couldn't differentiate between dreams and reality and had repeated nightmares.
Did anything like this ever happen to you when you were in the psych ward, sploo?The following users say it would be alright if the author of this post didn't die in a fire!
