This is why you'll forever remain one of the biggest jokes on this website. Thanks for the laugh but this is honestly embarrassing. Sounds impressive, right? Looks like somebody googled a few phrases that agreed with their position and posted up some big, fancy government websites.
The problem is that I'm not a stupid kid that spends all day high on cough syrup in his parents' basement and can actually understand these articles. Also, unlike you
who can only access the fucking abstract because you don't have access to these databases (whereas I do because I actually made a living doing research), I can actually read the articles I'm posting up.
http://www.ncbi.nlm.nih.gov/pubmed/24526455
Dextromethorphan (DM), a sigma receptor agonist and NMDA receptor antagonist, protects neurons from glutamate excitotoxicity, hypoxia and ischemia, and inhibits microglial activation, but its effects on differentiation and protection of cells in the oligodendroglial lineage are unknown. It is important to protect oligodendroglia (OL) to prevent demyelination and preserve axons, and to protect oligodendroglial progenitors (OPC) to optimize myelination during development and remyelination following damage. Enriched glial cultures from newborn rat brain were used 1-2 days or 6-8 days after shakeoff for OPC or mature OL. DM had large effects on glial proliferation in less mature cultures in contrast to small variable effects in mature cultures; 1 μM DM stimulated proliferation of OPC by 4-fold, microglia (MG) by 2.5-fold and astroglia (AS) by 2-fold. In agreement with increased OPC proliferation, treatment of OPC with DM for 3 days increased the % of OPC relative to OL, with a smaller difference by 5 days, suggesting that maturation of OPC to OL was "catching up" by 5 days. DM at 2 and 20 μM protected both OL and OPC from killing by glutamate as well as NMDA, AMPA, quinolinic acid, staurosporine, and reactive oxygen species (ROS). DM did not protect against kynurenic acid, and only modestly against NO. These agents and DM were not toxic to AS or MG at the concentrations used. Thus, DM stimulates proliferation of OPC, and protects both OL and OPC against excitotoxic and inflammatory insults.
"Inhibits microglial activation?" Sounds great! If you're suffering from neuroinflammation. Optimizing Myelination and remyelination? Impressive. That is, if you're a newborn who hasn't undergone pruning yet.
Wow, what a surprise,
that's exactly what the study was on. Newborn rat brains that were eight days old at the latest. So congratulations, if you're a newborn damaged rat brain undergoing surgery,
very small amounts of DM are used to insulate damage and preserve axons.
Nothing about neurogenesis is even in here. In fact, the word isn't even used.Let's see what else the self-proclaimed genius has to for us.
http://www.ncbi.nlm.nih.gov/pubmed/17848867
"
Mounting preclinical evidence has proven that DM has important neuroprotective properties in various CNS injury models, including focal and global ischemia, seizure, and traumatic brain injury paradigms."
"DM's protection of dopamine neurons in parkinsonian models may be due to inhibition of neurodegenerative inflammatory responses."
"Clinical findings are limited…"
"Small studies have shown some promise for treatment of perioperative brain injury, amyotrophic lateral sclerosis, and symptoms of methotrexate neurotoxicity. DM safety/tolerability trials in stroke, neurosurgery, and amyotrophic lateral sclerosis patients demonstrated a favorable safety profile.""
Conclusion:… this strategy may hold promise for the treatment of various acute and degenerative neurologic disorders."Once again we see an article that doesn't support your position at all because you're too much of a fuck up to read and understand it. Maybe we should be like the kids you knew in middle school who were impressed by the big sounding words official government medical studies (that you can't read because you can't access the database). Just like in the last article, unless you're a vegetable suffering from Traumatic Brain Injury, suffering from degenerative brain disorder, or your brain is on a plate because you're an 8 day old rat, bundy is not helpful for you. In fact..
http://www.sciencedirect.com/science...91305709002202
"
The goal of this study was to determine the neuroprotective profile of DM in a military-relevant model of penetrating ballistic-like brain injury (PBBI). "
That's the same thing in this article.
http://www.fasebj.org/content/18/3/589.full
"
Neuroprotective effect of dextromethorphan in the MPTP Parkinson’s disease model: role of NADPH oxidase"And the same thing in this one. Do you have Parkinson's Disease, Sploo?
It has been hypothesized that reducing glia-mediated inflammation could diminish neuronal loss.
" It has been hypothesized that reducing glia-mediated inflammation could diminish neuronal loss."Wow, interesting how I knew neuralinflammation was related to degenerative brain damage. I mentioned this in the first article. This one is about Alzheimer's. Do you have Alzheimers, Sploo?
http://www.ncbi.nlm.nih.gov/pubmed/22730040
I guess you're schizophrenic?
Look kid, you're not impressing anybody here. Some of us actually went to school for this shit and have published research on it. The rest of the people here who didn't but aren't completely stupid have the critical thinking skills to know nonsense when they see it. The only article posted in this entire thread that's relevant to you abusing cough medicine repeatedly is the one I posted - guess what it's about?
"
Clinical studies showed that chronic consumption of cough mixture at high dosages may lead to psychiatric symptoms, especially affective disturbance."
Did you notice how my one article is better than all of yours because it supports my point that being a stupid fucking kid who drinks tons of cough syrup everyday is actually empirically supported in the evidence? Notice that it didn't have to hide behind a bunch of pretentious gobbledygook which you don't (but I do) understand?
I already know how this is going to end. You're going to act like this was all just a ruse to "make oplus mad olololololol he's so mad." I have news for you dumbass, there are plenty of actually intelligent and capable kids who take this shit because MOON PERSON shitbags like you are so preoccupied with the lie that you're such a special snowflake with limitless potential that it's okay to abuse cough syrup and think it's "making you smart."Now your shame is on the internet, called out by someone who actually holds a degree in the field, among an audience of people who should know better, and we finally have empirical objective evidence that you're a fucking idiot.
Carry on and enjoy being "rekt" you stupid fuck. Enjoy having all sorts of affect disorder symptoms in your late twenties (if you live that long).
