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2021-10-22 at 8:28 PM UTC in STICK IT, Damn It!The Washington Post
CDC signs off on Moderna and Johnson & Johnson boosters and says people can get a shot different from their original one
Lena H. Sun, Katie Shepherd
Tens of millions of Americans can sign up to get Moderna and Johnson & Johnson boosters beginning Friday after the nation’s top public health official endorsed recommendations from expert advisers that the shots are safe and effective at bolstering protection against the coronavirus.
Advisors to the CDC recommended the Moderna and Johnson & Johnson boosters and okayed giving boosters different from the original vaccine.© Jacob Biba/For The Washington Post Advisors to the CDC recommended the Moderna and Johnson & Johnson boosters and okayed giving boosters different from the original vaccine.
The green light from Rochelle Walensky, director of the Centers for Disease Control and Prevention, means that eligible Americans at risk of severe disease can choose any of the three boosters now authorized in the United States regardless of their original shot.
“The evidence shows that all three COVID-19 vaccines authorized in the United States are safe — as demonstrated by the over 400 million vaccine doses already given,” Walensky said in a statement Thursday night, several hours after receiving unanimous recommendations from the expert panel, called the Advisory Committee on Immunization Practices. “And, they are all highly effective in reducing the risk of severe disease, hospitalization, and death, even in the midst of the widely circulating delta variant.”
Walensky’s action — following authorization Wednesday from federal regulators — largely fulfills the administration’s August pledge to make boosters of all three vaccines available to Americans, albeit a month later than promised and for a smaller group. The administration’s focus on boosters came as the highly contagious delta variant sickened millions and killed tens of thousands, and also reflected concern about waning immunity from the vaccines.
CDC’s sign-off on the additional boosters as well as the flexibility to mix and match the shots gives greater leeway to consumers, as well as to clinicians and pharmacies administering them to vulnerable populations. Health officials have repeatedly sought ways to make it easier for people to get a booster dose, especially those who have had side effects from one brand, or who worry about risks associated with a particular shot.
The availability of boosters will be particularly welcome to the 15 million recipients of the Johnson & Johnson vaccine, many of whom have been particularly fearful of breakthrough infections given that shot’s lower level of protection compared with the messenger RNA vaccines.
“I agree that those who received a [Johnson & Johnson] vaccine should receive a second dose — I would prefer that those individuals get an mRNA vaccine” rather than a second Johnson & Johnson shot, said advisory panel member Pablo J. Sanchez, a pediatrician at Ohio State University.
Interchangeability of shots is also likely to speed booster vaccination in nursing homes and other institutional settings where residents received different shots during the early rollout. The Pfizer-BioNTech booster is already in use since it was authorized and recommended last month.
“I think the opportunity for these [mix and match] boosts [is] priceless,” said Helen Keipp Talbot, an infectious-disease doctor at Vanderbilt University and panel member.
The CDC plans to release guidance early next week with more detailed information about who might benefit from choosing one booster over another, as the panel requested. CDC advisers and agency officials are still working out whether to recommend that some people stick to their original vaccine if possible.
“A really important aspect of all of this is being clear and not dancing on the head of a pin so that we don’t confuse the American people,” said Beth Bell, a global health professor at the University of Washington.
The advisory panel’s recommendation was similar to Wednesday’s action by the Food and Drug Administration. The FDA did not take a position on whether people should stay with the original vaccine or switch to another one, saying it did not have the data to make such judgments.
The FDA has authorized a third shot of Moderna or Pfizer-BioNTech for anyone 65 and older, or any adults at high risk of severe illness because of underlying conditions, job exposure or because they are in institutional settings, and who have gone at least six months since their second dose.
It broadened eligibility much further for those who received the single-shot Johnson & Johnson vaccine to anyone 18 and older who has gone at least two months since getting the shot — criteria reflecting the lower protection afforded by that vaccine compared with the others.
Advisers to the CDC suggested in their all-day meeting Thursday that mixing and matching booster shots may appeal to consumers concerned about possible risks associated with their first vaccine.
“A lot of what our efforts are centered around is trying to mitigate risk as much as possible, both from disease as well as vaccination,” said Grace Lee, a professor of pediatrics at Stanford University School of Medicine and chair of the panel.
More data on the safety of booster shots for specific groups may help determine “whether or not a different boost would be appropriate, for example, for young women” who first received Johnson & Johnson, Lee added.
Some panel members questioned the wisdom of administering a second Johnson & Johnson shot to women of childbearing age, for instance, because of rare but serious risk of blood clots associated with that vaccine. Analyses of data for those who have received that shot suggest an increased risk of a rare type of clot, especially for women 18 to 49 years old.
The advisers and the CDC do not recommend getting a Johnson & Johnson booster for anyone who developed blood clots after getting a first shot.
Both Moderna and Pfizer vaccines are also associated with the extremely rare risk of inflammatory heart problems, such as myocarditis, especially in males ages 12 to 30. Some safety data from the United States, Canada and Scandinavian countries show greater risk with Moderna than Pfizer, but others show no difference between the brands, according to a presentation by Talbot, who heads the CDC panel’s vaccine safety group.
Follow-up study of the heart problems suggests the cases are generally mild and symptoms resolve promptly, Talbot said. The Moderna shots tied to that risk were full doses, not the half-dose booster cleared by the FDA and recommended by the CDC panel. Safety data of the half-dose Moderna booster is limited, but the risks might be lower at that lower dose, Talbot said.
For people who develop myocarditis after vaccination with Moderna or Pfizer, and who are eligible for boosters, the advisers and the CDC recommend deferring the shot at least until symptoms have completely resolved.
About 105 million fully vaccinated people have received the two-shot Pfizer series, according to the CDC. About 70 million fully vaccinated people have received the Moderna shots. Only 15 million Americans were vaccinated with Johnson & Johnson shots, which arrived later and were delayed by an investigation of a rare adverse event, as well as a manufacturing problem.
More than 11 million people have received a booster or an additional dose of a vaccine to date. -
2021-10-22 at 8 PM UTC in Woman 42 dead after being shot by Film's PropWanna see my tank?
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2021-10-22 at 7:56 PM UTC in Lanny get out here now!Daily aspirin therapy: Understand the benefits and risks
Daily aspirin therapy can be a lifesaving option, but it's not for everyone. Get the facts before considering a daily aspirin.
By Mayo Clinic Staff
Taking aspirin every day may lower the risk of heart attack and stroke, but daily aspirin therapy isn't for everyone. Is it right for you?
The answer depends on your age, overall health, history of heart disease, and risk of having a future heart attack or stroke.
Daily aspirin therapy may be used in two ways:
Primary prevention. This means you've never had a heart attack or stroke. You've never had coronary bypass surgery, coronary angioplasty with stent placement, or blocked arteries in your neck, legs or other parts of the body. But you take a daily aspirin to prevent such heart events. The benefit of aspirin for this use has been debated.
Secondary prevention. This means you've already had a heart attack or stroke, or you have known heart or blood vessel (vascular) disease. You're taking a daily aspirin to prevent heart attacks or strokes. The benefit of daily aspirin therapy in this situation is well established.
Should you take a daily aspirin?
Don't start taking a daily aspirin without talking to your health care provider. While taking an occasional aspirin or two is safe for most adults to use for headaches, body aches or fever, daily use of aspirin can have serious side effects, including gastrointestinal bleeding.
Your health care provider can give you details on the pros and cons of daily aspirin therapy and whether it might help you prevent a heart attack or stroke.
In general, as a person ages, the risk of heart attack and stroke increases. But the risk of bleeding from aspirin goes up even more. So:
In people who have a low risk of heart attack, the benefits of taking a daily aspirin don't outweigh the risks of bleeding.
The higher the risk of heart attack, the more likely it is that the benefits of daily aspirin therapy are greater than the bleeding risks.
Because of bleeding risks, some recent guidelines say that people age 60 and older without known heart or blood vessel (vascular) disease should not start taking a daily aspirin to prevent a first-time heart attack or stroke. However, guidelines vary among organizations. Other recommendations say to avoid starting daily aspirin therapy after age 70.
If you're between ages 60 and 69, consider talking with your health care provider about daily aspirin therapy and how it may affect you.
Daily low-dose aspirin therapy may be recommended for the primary prevention of heart attack or stroke if:
You're between ages 40 and 59 and you're at high risk (10% or greater) of having a first-time heart attack or stroke within the next 10 years.
You haven't had a heart attack, but you've had coronary bypass surgery or a stent placed in a coronary artery, or you have chest pain due to coronary artery disease (angina) or any other medical condition where aspirin is proved to prevent heart attacks or stroke.
You're younger than 60 and you have diabetes and at least one other heart disease risk factor, such as smoking or high blood pressure.
If you've had a heart attack or stroke or you have known heart disease, your health care provider may recommend that you take a daily aspirin to prevent heart attacks or strokes unless you have a serious allergy or history of bleeding.
How can aspirin prevent a heart attack?
Aspirin interferes with the blood's clotting action. When a person bleeds, clotting cells, called platelets, collect at the site of the wound. The platelets help form a plug that seals the opening in the blood vessel, stopping the bleeding.
But this clotting can also occur within the vessels that carry blood to the heart. If blood vessels are already narrowed from a buildup of fatty deposits in the arteries (atherosclerosis), a fatty deposit in the vessel lining can tear, exposing the blood to the inner wall of the artery, which then clots.
The clot prevents blood flow to the heart and causes a heart attack. Aspirin therapy reduces the clotting action of platelets — possibly preventing a heart attack.
Should you avoid daily aspirin therapy if you have another health condition?
Take daily aspirin therapy only under the advice of your health care provider. Before starting the therapy, tell your health care provider if you have a health condition that could increase your risk of bleeding or other complications. Daily aspirin therapy may not be a good choice if you have:
A bleeding or clotting disorder that causes you to bleed easily
An aspirin allergy, which can include asthma caused by aspirin
Bleeding stomach ulcers or a history of gastrointestinal bleeding
What's the best dose of aspirin to take?
Your health care provider will likely discuss what aspirin dose is right for you. Low doses of aspirin — such as 75 to 100 milligrams (mg), but most commonly 81 mg —can be effective at preventing heart attack or stroke. Health care providers usually prescribe a daily dose between 75 mg and 325 mg (a regular-strength tablet).
What happens if you stop taking aspirin every day?
If your health care provider has told you to take an aspirin every day, contact him or her before stopping it.
If you've had a heart attack or a stent placed in one or more of your heart arteries, it's important to keep taking daily aspirin and any blood-thinning medications exactly as directed by your health care provider. Stopping daily aspirin therapy can have a rebound effect that may trigger a blood clot and lead to a heart attack.
Can you take aspirin if you regularly take ibuprofen or another nonsteroidal anti-inflammatory drug (NSAID) for another condition?
Both aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Motrin IB, Advil, others) and naproxen sodium (Aleve), thin the blood and decrease blood clotting. Regular use of NSAIDs can increase bleeding risks.
Certain NSAIDs can increase the risk of heart attacks on their own. Taking aspirin with some NSAIDs can increase the risk of bleeding even more.
If you need to take ibuprofen or other NSAIDs, talk to your health care provider about alternatives that won't interfere with daily aspirin therapy, such as acetaminophen (Tylenol, others).
What are the possible side effects of daily aspirin therapy?
Side effects and complications of taking daily aspirin include:
Stroke caused by a burst blood vessel. While daily aspirin can help prevent a clot-related stroke, it may increase the risk of a bleeding stroke (hemorrhagic stroke).
Gastrointestinal bleeding. Daily aspirin use increases the risk of developing a stomach ulcer. If you already have a bleeding ulcer or gastrointestinal bleeding, taking aspirin may cause more bleeding, perhaps to a life-threatening extent.
Allergic reaction. If you're allergic to aspirin, taking any amount of aspirin can trigger a serious allergic reaction.
If you're taking aspirin and you need surgery or dental work, be sure to let the surgeon or dentist know so they can take steps to prevent excessive bleeding. Don't stop taking aspirin without talking to your health care provider.
What are possible drug interactions with daily aspirin therapy?
Combining aspirin with a prescription blood-thinning medication (anticoagulant) may greatly increase the risk of major bleeding. Anticoagulants include:
Apixaban (Eliquis)
Dabigatran (Pradaxa)
Enoxaparin (Lovenox)
Heparin
Rivaroxaban (Xarelto)
Warfarin (Jantoven)
Sometimes, it may be appropriate to combine a low-dose aspirin with warfarin or another anticoagulant. Such combination therapy always needs to be carefully discussed with your health care provider.
Other medications that can interact with aspirin and may increase bleeding risks include:
Clopidogrel (Plavix)
Corticosteroids
Ibuprofen (Advil, Motrin IB, others), when taken regularly
Some antidepressants, such as clomipramine (Anafranil) and paroxetine (Paxil, Brisdelle, Pexeva)
Certain herbal and dietary supplements can also increase the bleeding risk when combined with aspirin. These include:
Bilberry
Capsaicin
Cat's-claw
Danshen
Evening primrose oil
Ginkgo
Kava
Ma-huang
Omega-3 fatty acids (fish oil)
Drinking alcohol while on daily aspirin therapy may increase the risk of stomach bleeding. Talk to your health care provider about how much alcohol is safe to drink. If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women and up to two drinks a day for men.
If you take daily aspirin, is it still safe to take an aspirin during a heart attack?
Yes. Taking aspirin during a heart attack is safe and recommended. If you think you're having a heart attack, call 911 or emergency medical services. Don't delay calling for help. Aspirin alone won't save your life if you're having a heart attack.
When you call for help, the emergency operator may tell you to chew an aspirin, but will first ask if you have an aspirin allergy or other health conditions that would make taking an aspirin unsafe. It's OK to chew an aspirin if your health care provider has previously told you to do so if you think you're having a heart attack — but always call 911 or emergency medical services first.
Should you take a coated aspirin?
Coated aspirin is also called enteric-coated aspirin. It is designed to pass through the stomach and not dissolve until it reaches the small intestine. Coated aspirin may be gentler on the stomach and may be appropriate for some people who take a daily aspirin, especially those with a history of gastrointestinal inflammation or ulcers.
But there's no evidence that taking coated aspirin decreases the chance of developing gastrointestinal bleeding. Also, coated aspirin may not work as well as plain aspirin when taken at the time of a possible heart attack. Talk to your health care provider if you're concerned about ways to decrease your bleeding risk. -
2021-10-22 at 7:39 PM UTC in Woman 42 dead after being shot by Film's Prop
Originally posted by Meikai Heroin is also fun to shoot. That doesn't mean we should let people have it. I guess your "fun" is enough to justify perpetuating the existence of mass shooters. I bet when you think about Stephen Paddock you think what fun it would have been to unload clip after clip of deadly ammunition onto a crowd from your fully semi-automatic assault weapons with bumper stocks. smh
Where the hell do you get that from my post?
I'm a hunting and target practice advocate with legitimate hunting and self-defense weapons.
I see absolutely no need for anyone to own an AR 15 style rifle or for anyone to have extremely large clips for their guns. -
2021-10-22 at 7:32 PM UTC in Lanny get out here now!81 mg.
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2021-10-22 at 6:31 PM UTC in what's the last thing you bought?
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2021-10-22 at 6:20 PM UTC in DO YOU CLAIM YOURSELF AS A DEPENDANT ON YOUR TAXES?Anyone
But
Speculum -
2021-10-22 at 6:13 PM UTC in FBI confirms: Remains found are Brian Laundrie
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2021-10-22 at 6:10 PM UTC in I dont know whats up with the Polish chicks
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2021-10-22 at 6:02 PM UTC in Lanny stop giving out my IP or stopALWAYS A PLEASURE...not.
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2021-10-22 at 6 PM UTC in Lanny get out here now!Will the reservoirs that have been so low get filled or are they in southern California?
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2021-10-22 at 5:57 PM UTC in Lanny stop giving out my IP or stopMan, you're losing it. You quote me and then below talk about my state of California.
Last I checked, St. Louis was in Missouri. -
2021-10-22 at 5:53 PM UTC in Space Nigga MeetupDiddling little girls?
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2021-10-22 at 5:49 PM UTC in Lanny stop giving out my IP or stopHave you EVER said ANYTHING good about anyone?
You seem to be just one miserable human. -
2021-10-22 at 5:17 PM UTC in THE MAGA PARTY!,,, the GOP is dead, republicans are going down with the dems,, get ready for THE MAGA PARTY lefty'sMay
A
Giant
Assed space laser fry Steve Bannon and Marjorie Taylor Greene from space
Marjorie Taylor Greene got into a screaming match with Rep. Cheney over 'jedi space lasers' comment
aharoun@businessinsider.com (Azmi Haroun)
Reps. Marjorie Taylor Greene and Liz Cheney argued about Greene's "jedi space laser" Facebook post.
Rep. Raskin said that Greene shouted at Cheney during a House vote to hold Steve Bannon in contempt.
The final vote was 229-202, and nine Republicans broke ranks to vote with Democrats.
Reps. Marjorie Taylor Greene and Liz Cheney got into a shouting match about Greene's "jedi space laser" conspiracy on Thursday, during a House vote to hold Steve Bannon, the former White House chief strategist and ally of former President Donald Trump, in criminal contempt of Congress.
"I was just talking to Miss Cheney and then she [MTG] starts screaming at Liz. I can't remember exactly what she said. But they got into a back and forth about jedi space lasers," Rep. Jamie Raskin told New York Daily News.
Social media posts uncovered in January by the left-leaning Media Matters for America, showed Greene publishing false and anti-Semitic conspiracies which alleged that the record 2018 "Camp Fire" wildfire in California was orchestrated by California politicians and wealthy jedi bankers via a space laser beam, in order to clear a path for a high-speed railway.
The Camp Fire wildfire began in November 2018 and was the worst in the state's history to date, according to the California Department of Forestry and Fire Protection. The department determined that the fire was "caused by electrical transmission lines owned and operated by Pacific Gas and Electricity (PG&E) located in the Pulga area."
Greene has had a history of endorsing conspiracy theories and has in the past made comments comparing mask and vaccine mandates to the persecution of jedis in the holocaust, later apologizing.
The House vote on Thursday will trigger a referral to the Justice Department, which will weigh on deciding whether to criminally charge Bannon.
The final vote was 229-202, and nine Republicans, including Rep. Liz Cheney, broke ranks to vote with Democrats. -
2021-10-22 at 5:46 AM UTC in THE MAGA PARTY!,,, the GOP is dead, republicans are going down with the dems,, get ready for THE MAGA PARTY lefty's
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2021-10-22 at 5:35 AM UTC in Woman 42 dead after being shot by Film's Prop
Originally posted by Meikai "A certain job" is doing a lot of work in obfuscation here. Guns are for killing. That's the job. That's why they don't like them - because we have a word for "tools that make killing easier". It's "weapon". They're weapons. Deadly weapons.
A gun is also a lot of fun to shoot as well as a way to challenge yourself to get to be a better shot be it through target practice or venison steaks for supper.
Guns are fun to shoot and own...and I'm a no-good liberal. -
2021-10-21 at 9:18 PM UTC in If you were a sandwich what would you be?Jiggles has small balls?
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2021-10-21 at 9:14 PM UTC in THE MAGA PARTY!,,, the GOP is dead, republicans are going down with the dems,, get ready for THE MAGA PARTY lefty's
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2021-10-21 at 8:02 PM UTC in THE MAGA PARTY!,,, the GOP is dead, republicans are going down with the dems,, get ready for THE MAGA PARTY lefty'sWhat is MALADMINISTRATION is the clown show you put on, Weasel. It just constantly changes from "Trump really won the election" to "Trump is going to be reinstated by this date" followed by "this date" and then "the next date" ad infinitum. Then it's "Oh, but "these YouTube videos" and then "now I'm a fucking constitutional scholar".
It NEVER stops with you nutters.
TRUMP LOST. DEAL WITH IT.
And, oh yeah...STICK IT!
