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Posts by gadzooks
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2018-11-29 at 5:48 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
Originally posted by GGG It's kind of hard for me to imagine a brain developing MORE receptor sites. You'd think "Hey, you got what you got" but somehow the body can just make more?
Like when I imagine this I'm thinking of all the little axon ends poopin up 3d models of drugs. Then suddenly receptors begin sprouting out of the base of your brain like a forest. Their rounded, cuppish hands grasp like peasants at their king as they scream and beg for more drugs.
Seriously though where the fuck does the matter for this come from? Have the receptors always been there, just waiting to be activated? Is the brain repurposing transmitter sites? Da fuqs goin on
Lol, dude, that's EXACTLY what it does...
I took a whole 4th year (undergrad) special topics class on LTP (Long-Term Potentiation - basically, the biology of memory).
I did an entire project and half hour lecture on dendritic spine remodeling.
Dendritic spines are the connectors that sprout and connect to other neurons.
This stuff ain't science fiction. -
2018-11-29 at 5:34 AM UTC in I know alot of you have |sexual problems|I don't think I've had a boner in like a week.
For some reason, though, I'm not particularly bothered by it.
Maybe too preoccupied with other concerns. -
2018-11-29 at 5:32 AM UTC in Bill Bill Krozbyby has decided that his daughter is an inconvenience...
Originally posted by Bill Krozby Yeah whatever, but i have other traits that balance it out. its all give in take in this world, you'll never have it all.
"dare to take the rational black pill fam?"
Why are you all of a sudden sounding reasonable and congenial?
Aren't you usually a total prick?
Or has my opinion of you been swayed by that of the masses here at NIS? -
2018-11-29 at 5:29 AM UTC in Psychedelics are fool's gold
Originally posted by Mr Gay Men Watch I don't think psychs reveal any higher order truths. I don't think anyone who does psychs has a "truly" transcendental experience. Ultimately it is just a hallucination induced by the brain in a state of extreme suggestibility.
It can lead to some positive outcomes but ultimately it gives us easy, convincing delusions of cosmic oneness, transcendence etc to face ourselves towards, to avoid facing the truth. Now psychedelics have become the new "spiritual" frontier. It's become the new bastion for crackers with existential angst to be religious, now that religion is a joke.
Human beings are a tragic species. I think the long term happiness of mankind will heavily hinge on hs coming to grips with the fact that self awareness is a cosmic joke; the sooner we accept the absurdity of our position, the quicker we can get to doing something worthwhile with our time.
This was surprisingly insightful coming from someone named "Mr Gay Men Watch".
It's true, an existential void has been created with the death of religion, officially declared by Nietzsche over a century ago.
Drugs are a way of experiencing something beyond day-to-day experience, and allows us to truly feel.
Accepting the absurdity of our condition is no simple task.
In fact, I am coming to believe that it is literally impossible, and all we can do is keep on trying, with whatever resources are available to us (religion, drugs, gene therapy, transhumanism, etc).
Only in death are we released from this void. -
2018-11-29 at 5:24 AM UTC in Bill Bill Krozbyby has decided that his daughter is an inconvenience...
Originally posted by Bill Krozby Just because you're not sure doesn't mean its not a thing.
I get told all the time by girls that I remind them of their dad because I have a beard and that I'm intolerant and conspiracy theorist
some girl called me a fat ass the other day and I lifted up my shirt and said only my belly is fat but my ass isn't
None of these are positive traits. -
2018-11-29 at 5:20 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
Originally posted by GGG We could go the route of kava and add reverse tolerance. I believe the kavalactone responsible for this is kavain, which is an allosteric something something something something. It increases the amount of receptor sites though, which is pretty fucking interesting when you think about it. Imagine your drug addiction getting CHEAPER over time.
Yeah that is a really interesting phenomenon, and it just goes to show the potential to engineer drugs and drug receptors to behave similarly with other drugs. -
2018-11-29 at 5:20 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
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2018-11-29 at 5:16 AM UTC in Bill Bill Krozbyby has decided that his daughter is an inconvenience...
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2018-11-29 at 4:53 AM UTC in Bill Bill Krozbyby has decided that his daughter is an inconvenience...
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2018-11-29 at 4:51 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
Originally posted by GGG I like the GABA idea. GABAgadzooks. GABAg
I was trying to find this information on an opiate that was apparently non-psychoactive but still had some pretty decent analgesic properties. Can't find shit tho. Idk if anyone knows what I'm talking about, but I really wanna look at the mechanism for that right now. I really need to start taking notes.
While the application is years away, the theory is open to all kinds of possibilities.
I've always wanted to try an opiate / hallucinogen (psilocybin or LSD, most likely) combination, but I can't anymore because I swore off opiates 4 years ago. -
2018-11-29 at 4:48 AM UTC in Bill Bill Krozbyby has decided that his daughter is an inconvenience...
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2018-11-29 at 4:46 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can beOh, and drug tolerance of any kind whatsoever... L to the O to the L.
We won't be having any of that now. -
2018-11-29 at 4:45 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
Originally posted by mashlehash You know I've went through my own instance of experience. What do you think of the sigma receptors?
Oh, that reminds me...
I'd also design completely non-habit-forming opiates.
There would be no come down / withdrawals whatsoever. You just gradually, over the course of about 5 to 10 minutes, return to normal and have zero cravings, only mild curiosity to try it again. -
2018-11-29 at 4:39 AM UTC in Soup niggers
Originally posted by Snoopy FUCK! I mean, SHIT! Crap is getting fucking HECTIC! People fucking suck! God damn it I fucking hate children. Stupid dumbass children are always fucking bitching about shit not being real or fucking realistic. FUCK YOU! FUCKING YOUR ASS IS REALISTIC! Fucking piece of SHIT! Like, someone does some funny shit for a gag, and they say it's not funny cause it's fake. WHAT THE FUUUUCK?! Reality fucking SUCKS! People are getting fucked in the ass and crap smells like SHIT! God damn Vin Diesel jumping out of a plane on a fucking neutron bomb while FUCING 17.000 mexican bitches and recovering from a fucking kebap diarrhea infection, shot real time fucking SUCKS! FUCK A BALD MAN CAUSE HE'S SHIT! God damn!
I mean, FUCK! I was riding the metro the other FUCKING DAY! And they have these FUCKING retarded regulations that you can't buy FUCKING tickets on the damn tram itself. So this dumbshit fucking prick gets on and buys one anyway. The driver is being all fucking friendly and FUCKING SHIT! I don't FUCKING give a shit, being myself and then this fucking NIGGER gets on. He goes up to the driver and asks for a ticket. The FUCKING RETARD DRIVER hands him a paper with the metro regulations and tells him to “fucking read it, if you can”. I got up and said: “FUUUUUCK!!!” WHAT THE FUCK! I yelled: “NIGGER, SELL THE MOTHERFUCKING BLACK MAN A GOD DAMN TICKET YOU FUCKING PIECE OF SHIT! WHY THE FUCK DID YOU SELL THIS OTHER GARBAGE-FUCKING-EATER A FUCKING TICKET?!” What the HELL is this FUCKING SHIT?! God damn, I'm like just FUCKING sitting there, minding my god damn business like EVERYONE ELSE SHOULF FUCKING BE, when this FUCKING retard starts making a FUCKING problem. For all you fucking know, BITCH, the African feller has a Ph.D in FUCKING YOUR ASS, FUCKING ASSHOLE! I mean, FUCK!
And SHIT! I fucking hate FUCKING dumb people. Last Sunday, I was having a fucking hangover at this fucking BBQ. It was like, FUCK! Then a couple of blocks away, this FUCKING CROMAGNON PEA BRAINED PIECE OF SHITEATING FECESFACE starts acting all fucking tough in front of the red lights, trying to fucking DRAG RACE A FUCKING MOTOR CYCLE. WHAT THE FUUUUCK?! So the dude on the motor is like, what the fuck?! And when the MORON realizes how much of a DUMB SHIT he is, he FUCKING RAMS THE MOTOR CYCLE OFF THE ROAD, KILLING THE BITCH IN THE BACK?! WHAT THE HELL?! Don't FUCKING ram people off the FUCKING road you DUMB FUCKING JELLO BRAIN! God damn, FUCKING too bad I wasn't so FUCKING hung over and at a BBQ. I fucking witness that, I FUCKING RUN AFTER YOUR SORRY ASS FUCKING TERMINATOR STYLE AND RAM YOUR FUCKING HEMORRHOIDS OUT YOUR GOD DAMN COLON, BITCH ASS SHITDIVER!
And SHIT! Today, I said: FUCK! So I sat down in front of the GOD DAMN tv, which I hadn't seen in FUCKING FOREVER. Laurel & Hardy were on, and I said: FUCKING SHIT, THIS IS FUNNY CRAP! Then, BAM! My FUCKING mom takes the FUCKING remote VIBRATING control and FUCKING changes the GOD DAMN STATION! I said: BITCH, FUCK! Why the HELL'D YOU DO THAT FOR?! And she sayd: “STOP YELL YOU DICK, I WANT TO WATCH THE GOD DAMN NEWS!” God DAMN fucking news! HOLY SHIT! You watch the news over HUMOR?! Fuck, I'll give you the GOD DAMN NEWS! FUCKING TONY DICKLESS BLAIR WON THE GOD DAMN DUMBSHIT ELECTION! His 90 year old wife GOT FUCKED for being a PRICK! What the HELL?! Her FUCKING IUD FELL OUT OF HER FRIGGIN' CUNT FOR SMELLING LIKE SHIT! Fucking LABOR PARTY SHIT! What the HELL?!
Oh yeah, now that I mentioned England, it reminds me. I had my mate on the phone the other day, asking him what the FUCK we're doing on Saturday evening, and he said we're doing JACK FUCKING SHIT cause his woman is in FUCKING LONDON. WHAT THE FUCK IS LONDON?! I said: “SHIT! FUCKING HELL!”. Why the fuck aren't WE IN LONDON FUCKING TOO?! That was a stupid question, because his answer FUCKING KICKED MY ASS! He said: “WE FUCKING AREN'T IN LONDON BECAUSE IT SMELLS LIKE PAKI FUCKING SHIT! OUT OF 10 FUCKING MILLION DICKS, HALF OF THEM ARE FUCKING BROWN FOR BEING GAY FUCKING MUSLIM SHITS! FUCKING LONDON SUCKS! AND I'M NOT EVEN GETTING STARTED ABOUT FUCKING IT IN THE ASS! GOD DAMN I FUCKING HATE MUSLIM WOMEN TO SHIT!”. I asked him what his fucking problem was cause half his fucking friends are fucking brow, and he fucking RUINED ME AGAIN. He said: “FUCK YOU, SMARTASS DICKHEAD! WHAT THE FUCK YOU THINK IT'S FUNNY I HAVE TO ROT HERE IN THIS SHITHOLE WITH YOU GIVING ME THESE SEX PHONECALLS, FAGGOT?! FUCKING CAN'T A GUY BE A FUCKING HYPOCRITE?! ASSHOLE!”. I said: “YOU'RE RIGHT, DICK HEAD! LET'S GET DRUNK AND DRIVE ANYWAY, WORTH A SHIT AIN' IT?!”
Oh yeah, phonecalls. This brings me to my FUCING lawyer. I fucking called him the other day. THE NIGGER, he fucking say: “Hehe, Yes Sir Mr. Snoopy, but my provisions are depleted.”. I'm like: “What the HELL are you SHITHEADED SUITWEARING DICKHEAD talking about?! DAMN IT FUCKING THIS SHIT IS SERIOUS! I CAN'T FUCKING HAVE YOU FUCKING AROUND WITH ME!!!”. Then he said I should bitchslap his bankaccount with another 250. FUCKING LEECHBACK MOTHERFUCKING ASSFUCKER! I FUCKING PAID HIM LAST FRIGGIN MONTH! WHAT A FUCKING CAPITALIST WHORE BAG SHIT PISS FUCKING CUNTEATING MAGGOT!
And FUCKING AGAIN! I was taking a FUCKING shower earlier, when the FUCKING PHONE GOES OFF! This DICKHEAD from UNI calls to BITCH AT ME FOR DOING OR FUCKING NOT DOING SOME SHIT I DON'T FUCKING CARE ABOUT. I said: FUUUCK YOU, MOTHER FUCKING PIECE OF WORTHLESS UNWORTHY SHIT!!!” God damn it, FUCK I'm going to eat my GOD DAMN PHONE! So whenever the fuck it RINGS, I can FUCKING PUKE AT THEM, FUCKING ASSHOLES!
Now let's get back to public transportation and retards. Fuck, the other day I met NOTHING BUT RETARDED PEOPLE! And the only one who wasn't retarded was this arab dickhead whose mouth looked like a fucking CHESSBOARD SMEARED WITH SHIT! The missing teeth gaps were black, and his fucking teeth were brown. I fucking couldn't help LAUGHING MY FUCKING ASS OFF IN HIS FUCKING FACE! He also smelled like DOUCHE! ASSDOUCHE! None of that fancy CUNTDOUCHE. What the FUCKING HELL?! The retarded kids were FUCKING OUT OF THEIR GOD DAMN MIND! One of them was reading all the fucking GAYPHONE AND DRUGBOX ads in the metro, and the OTHER WAS YELLING THE SAME FUCKING SHIT. Just repeating what the dickhead before him said. WHAT THE FUCK?! Then there was this poster for “Kingdom of Heaven” and some retarded kids tried to read it, but they pronounced “Heaven” as “SHIT”. I said: “HAHAHAHAHAHAH WHAT THE FUCK?!” That movie probably SUCKS, unless it explains why some arabs have red hair. HAAHA, fucking RAPED! DICKHEADS!
Oh shit, I skipped class this whole week so I could go FUCK this friend of mine every day. WHAT A GOD DAMN MISTAKE. She made me wear fucking CONDOMS which I HAD TO FUCKING PAY FOR, cause she's TOO FUCKING DUMB TO SWALLOW A PILL EVERY FUCKING DAY!! STUPID BITCH, THE FUCKING CONDOMS COST MORE THAN A FUCKING HOOKER!! Then I noticed I got the FUCKING WRONG ONES! The only condoms worth a DICK are the extra thin ones. Everything else feels like FUCKING A PLASTIC BAG FILLED WITH GLASS SHARDS! God damn SUPID BITCH made me go LIMP. She fucking thought it'd be cool if she only shaved half of her fucking pubes. HER GOD DAMN CUNT LOOKED LIKE TWO FACE FROM BATMAN, ONLY IT SMELLED LIKE SHIT! I convinced her we take a bath together, and then she gave me head, WHICH SUCKED! SHE FUCKED UP AT SUCKING?! GOD DAMN WHAT A WASTE OF FUCKING SPERM!
When I went home, I took a look at my bank account and SHIT! 0.98. I said: “FUUUUUCK THIS!” Friday, paycheck, but this communist shithole has some kind of non work day today, and the bank won't FUCKING give me my money until MONDAY. I fucking wasted all my god damn money on getting drunk, going to a Chinese restaurant and ordering DIM SUMs until I SHAT MYSELF! FUCK! God damn SHIT!
Oh yeah, now that I've mentioned FUCKING communists. A while ago, there was some kind of DUMBSHIT protest. IDIOT people fucking think 365 days a year isn't enough to be FUCKING DUMB or some shit like that. Like, the FUCKING pinko fag communists decide to FUCKING protest against FUCKING globalisation, while at the SAME FUCKING TIME, the right wing neo FUCKING nazis protest against jedis and FUCKING brown poeople taking away their rights to SHIT. What the FUCK?! They got into a MASS FUCKING HOMO RIOT and when I tried to pass through the FUCING SHITHEADS, the God damn police fucking stopped me. What the FUCK?! I said: “AAYE YOU FUCKING SHITHEAD THESE FUCKERS DON'T HAVE THE RIGHT TO FIGHT IN OUR FUCKING STREETS! FUCKING GO ARREST SOME IDIOT SHITS YOU PIGFACED SHITEATING DOUGHNUTFUCKER!” The useless MOTHERFUCKER told me not to get WORKED up. FUCK YOU IN THE SPLEEN, BITCHFACE!
People seriously fucking SUCK BALLS! That's why service SUCKS! Next time you fucking walk into a store and have a go at the touchscreen devices, KNOW THAT WE SMEARED OUT OUR CUM OVER THOSE SCREENS, FUCKING FAGS! God damn stupid fucking DICKHEADS! No, the chick DOESN'T come with the TV, MORON! Thanks for being the 16357496 DUMB ASS today to ask that. And even if she did, WHAT FUCKING WOMAN WOULD GO HOME WITH A FACE LIKE YOURS?! No, the Palm Treo has got JACK FUCKING SHIT to do with a treesome, dumb ass. Go home and ponder the fact that you haven't been laid with a human female for the past fucking seven hundred years. FUCK!
Seriously, FUCK!
This was a work fiction. You're free to call any desired helpdesk and read that out loud as many times as you see fit. Reply with phrases like “too long/didn't read”, and your account will get FUCKED. Fucking totse dumbshit assholes. -
2018-11-29 at 4:22 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can beEither that, or artificial orgasms.
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2018-11-29 at 4:19 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
Originally posted by GGG Gadzooks, what designer receptors would you create?
The field is still in its infancy, so it's really hard to speak in terms of technical protocol, but, for one, I would create a bunch more targeted dopamine receptors (because too much dopamine in the wrong parts of the brain == schizophrenia).
Then, I'd upregulate some custom GABA receptors that don't induce benzo-like amnesia, so as to be in a tranquil state for the experience.
Then, I'd start experimenting with inducing hallucinations (i.e. the "trippy/psychedelic" part of the whole experience).
And then, maybe I'd selectively upregulate AMPA receptors so as to form more connections during the experience, so that it stays with you and you can recall it vividly at any time for decades to come. -
2018-11-29 at 4:12 AM UTC in If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
Originally posted by gadzooks chemogenetic techniques to actually ADD NEW DESIGNER RECEPTORS that we can design drugs specifically for.
Just sayin'.
It definitely bears repeating.
If your pineal glands aren't erect and salivating, you are lacking the imagination to see even one iota of the implications from this.
Naturally occurring hallucinogenic compounds are yesterday's news.
Fuck designer drugs, it's all about designer receptors. -
2018-11-29 at 4:03 AM UTC in OMG I Discovered the Meaning of Life...
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2018-11-29 at 3:59 AM UTC in What are you doing at the moment
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2018-11-29 at 3:56 AM UTC in LOL Facebook page is a blank white page? Haxors?
