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The Retardest Thread: Fashionably Late Edition.
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2018-03-28 at 8:47 AM UTCtfw 550mg of T-PAIN does nothing but give you weird dreams
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2018-03-28 at 8:48 AM UTC
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2018-03-28 at 8:48 AM UTC
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2018-03-28 at 8:49 AM UTC
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2018-03-28 at 8:49 AM UTC
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2018-03-28 at 8:50 AM UTC
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2018-03-28 at 8:52 AM UTC
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2018-03-28 at 8:54 AM UTCi would considered T-PAIN to be one of the shittiest drugs ive ever tried and ive eaten like 6 grams of it in my life just trying to understand why people would like it. same thing with phenibut. there's no euphoria only toxic feels and narcotism/autism
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2018-03-28 at 8:54 AM UTC
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2018-03-28 at 8:54 AM UTC
Originally posted by lempoid loompus i would considered T-PAIN to be one of the shittiest drugs ive ever tried and ive eaten like 6 grams of it in my life just trying to understand why people would like it. there's no euphoria
Heroin doesn't give me any euphoria, and it lasts like 15 minutes.
Some people respond better to some drugs than others -
2018-03-28 at 8:56 AM UTCI have been trying to get addicted to oxycodone but I can't. Is that an oppoisizxoide.? I just take a few and get kinda number happy. Not much better than getting drunk. Seems like a waste of time imo
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2018-03-28 at 8:57 AM UTC
Originally posted by Juicebox That's true of nicotine but I wouldn't say that for opiates
Although the only opioids that work on me anymore are T-PAIN and tramadol so maybe you're right
the thing both of these drugs have in common is action on serotonin. have you tried ssris, as in been on them for several months? since the serotogenic activity is more highlighted in your DOCs than the opiod activity, you might want to try exhausting all of your options in that first. -
2018-03-28 at 8:59 AM UTC
Originally posted by lempoid loompus the thing both of these drugs have in common is action on serotonin. have you tried ssris, as in been on them for several months? since the serotogenic activity is more highlighted in your DOCs than the opiod activity, you might want to try exhausting all of your options in that first.
Lol damn, how the fuck have I never realized that
I would never take SSRIs on a daily basis but maybe all I need is a serotonin boost once in a while
T-PAIN actually decreases serotonin though -
2018-03-28 at 9:01 AM UTCMaybe I should just try taking serotonergic psychedelics every weekend or two
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2018-03-28 at 9:26 AM UTCone might decrease and the other might increase serotonin on average, but how different parts of your brain interpret this change may be to either an excitatory or inhibitory effect depending on region that could reflate to both serotonin reuptake enhancers and serotonin reuptake inhibitors. SSRIs actually decrease levels of serotonin over time, like periods of months, because the brain develops more serotonin receptors to compensate for the changes, and long term use of SSREs will develop less serotonin receptors to compensate, although the mechanism for aantidepressant action has been more or less disproved for SSRE action, T-PAIN is now interpreted as a glutamate AMPA-receptor modulator, so from what you told me the mechanism of action for your long-term mood enhancement effects would either depend on short/long term SSRIs, short term SSREs, or AMPAkines. the mu-opioid action is actually secondary to your mood enhancing effects and because of that you should definitely focus on improving receptors that are less SELF DESTRUCT BUTTON.
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2018-03-28 at 9:42 AM UTCwanky language but interesting post
is it possible for the brain to retain the extra seratonin receptors after cessation of long-term SSRI use? given the withdrawal and normalisation of mood after coming off SSRIs I'd expect normal behaviour is that the newly activated receptors 'deactivate' over time -
2018-03-28 at 9:50 AM UTC
Originally posted by aldra wanky language but interesting post
is it possible for the brain to retain the extra seratonin receptors after cessation of long-term SSRI use? given the withdrawal and normalisation of mood after coming off SSRIs I'd expect normal behaviour is that the newly activated receptors 'deactivate' over time
i typed it in like a minute bitch
it will attempt to go back to baseline but no insults or alterations to brain structure or chemistry will leave absolute 0 everlasting effects, now imagine them accumulating over the years over time and you have alzhiemers/autism -
2018-03-28 at 10:02 AM UTC
Originally posted by lempoid loompus i typed it in like a minute bitch
it will attempt to go back to baseline but no insults or alterations to brain structure or chemistry will leave absolute 0 everlasting effects, now imagine them accumulating over the years over time and you have alzhiemers/autism
What are your thoughts on 5-htp as a supplement? -
2018-03-28 at 10:03 AM UTCBOOF IT!
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2018-03-28 at 10:07 AM UTC