The Retardest Thread: Fashionably Late Edition.

1. 2018-03-28 at 8:47 AM UTC

   #4861
   The Self Taught Man Black Hole
   tfw 550mg of T-PAIN does nothing but give you weird dreams
   
   
2. 2018-03-28 at 8:48 AM UTC

   #4862
   The Self Taught Man Black Hole

   Originally posted by lempoid loompus it means if you and everyone with similar intelligence to you got euthanized and the geniuses were able to reproduce uninhibited the world would be a 10000x better place

   
   144 is good enough for me
   
   And I only had to take the test once
3. 2018-03-28 at 8:48 AM UTC

   #4863
   The Self Taught Man Black Hole

   Originally posted by Juicebox tfw 550mg of T-PAIN does nothing but give you weird dreams
   
   

   
   see? youre a fucking worthless piece of garbage. since youve ran out of opiod highs and will never feel happiness again just shoot yourself like you said you would pussy
4. 2018-03-28 at 8:49 AM UTC

   #4864
   The Self Taught Man Black Hole

   Originally posted by Juicebox 144 is good enough for me
   
   And I only had to take the test once

   
   facebook doesnt count
5. 2018-03-28 at 8:49 AM UTC

   #4865
   The Self Taught Man Black Hole

   Originally posted by lempoid loompus see? youre a fucking worthless piece of garbage. since youve ran out of opiod highs and will never feel happiness again just shoot yourself like you said you would pussy

   
   Lol I quit T-PAIN months ago, I just got a couple grams for when I'm bored
6. 2018-03-28 at 8:50 AM UTC

   #4866
   The Self Taught Man Black Hole

   Originally posted by lempoid loompus facebook doesnt count

   
   Nah it was a real one. That was before most of the drugs though so it's probably more like 120 now
7. 2018-03-28 at 8:52 AM UTC

   #4867
   The Self Taught Man Black Hole

   Originally posted by Juicebox Lol I quit T-PAIN months ago, I just got a couple grams for when I'm bored

   
   opiates are shit drugs and the only people who enjoy them are already addicted to them. just like nicotine
8. 2018-03-28 at 8:54 AM UTC

   #4868
   The Self Taught Man Black Hole
   i would considered T-PAIN to be one of the shittiest drugs ive ever tried and ive eaten like 6 grams of it in my life just trying to understand why people would like it. same thing with phenibut. there's no euphoria only toxic feels and narcotism/autism
9. 2018-03-28 at 8:54 AM UTC

   #4869
   The Self Taught Man Black Hole

   Originally posted by lempoid loompus opiates are shit drugs and the only people who enjoy them are already addicted to them. just like nicotine

   
   That's true of nicotine but I wouldn't say that for opiates
   
   Although the only opioids that work on me anymore are T-PAIN and tramadol so maybe you're right
10. 2018-03-28 at 8:54 AM UTC

    #4870
    The Self Taught Man Black Hole

    Originally posted by lempoid loompus i would considered T-PAIN to be one of the shittiest drugs ive ever tried and ive eaten like 6 grams of it in my life just trying to understand why people would like it. there's no euphoria

    
    
    Heroin doesn't give me any euphoria, and it lasts like 15 minutes.
    
    Some people respond better to some drugs than others
11. 2018-03-28 at 8:56 AM UTC

    #4871
    

    mmQ Lisa Turtle
    I have been trying to get addicted to oxycodone but I can't. Is that an oppoisizxoide.? I just take a few and get kinda number happy. Not much better than getting drunk. Seems like a waste of time imo
12. 2018-03-28 at 8:57 AM UTC

    #4872
    The Self Taught Man Black Hole

    Originally posted by Juicebox That's true of nicotine but I wouldn't say that for opiates
    
    Although the only opioids that work on me anymore are T-PAIN and tramadol so maybe you're right

    
    
    the thing both of these drugs have in common is action on serotonin. have you tried ssris, as in been on them for several months? since the serotogenic activity is more highlighted in your DOCs than the opiod activity, you might want to try exhausting all of your options in that first.
13. 2018-03-28 at 8:59 AM UTC

    #4873
    The Self Taught Man Black Hole

    Originally posted by lempoid loompus the thing both of these drugs have in common is action on serotonin. have you tried ssris, as in been on them for several months? since the serotogenic activity is more highlighted in your DOCs than the opiod activity, you might want to try exhausting all of your options in that first.

    
    Lol damn, how the fuck have I never realized that
    
    I would never take SSRIs on a daily basis but maybe all I need is a serotonin boost once in a while
    
    T-PAIN actually decreases serotonin though
14. 2018-03-28 at 9:01 AM UTC

    #4874
    The Self Taught Man Black Hole
    Maybe I should just try taking serotonergic psychedelics every weekend or two
15. 2018-03-28 at 9:26 AM UTC

    #4875
    The Self Taught Man Black Hole
    one might decrease and the other might increase serotonin on average, but how different parts of your brain interpret this change may be to either an excitatory or inhibitory effect depending on region that could reflate to both serotonin reuptake enhancers and serotonin reuptake inhibitors. SSRIs actually decrease levels of serotonin over time, like periods of months, because the brain develops more serotonin receptors to compensate for the changes, and long term use of SSREs will develop less serotonin receptors to compensate, although the mechanism for aantidepressant action has been more or less disproved for SSRE action, T-PAIN is now interpreted as a glutamate AMPA-receptor modulator, so from what you told me the mechanism of action for your long-term mood enhancement effects would either depend on short/long term SSRIs, short term SSREs, or AMPAkines. the mu-opioid action is actually secondary to your mood enhancing effects and because of that you should definitely focus on improving receptors that are less SELF DESTRUCT BUTTON.
    The following users say it would be alright if the author of this post didn't die in a fire!

    • aldra
16. 2018-03-28 at 9:42 AM UTC

    #4876
    

    aldra JIDF Controlled Opposition
    wanky language but interesting post
    
    is it possible for the brain to retain the extra seratonin receptors after cessation of long-term SSRI use? given the withdrawal and normalisation of mood after coming off SSRIs I'd expect normal behaviour is that the newly activated receptors 'deactivate' over time
17. 2018-03-28 at 9:50 AM UTC

    #4877
    The Self Taught Man Black Hole

    Originally posted by aldra wanky language but interesting post
    
    is it possible for the brain to retain the extra seratonin receptors after cessation of long-term SSRI use? given the withdrawal and normalisation of mood after coming off SSRIs I'd expect normal behaviour is that the newly activated receptors 'deactivate' over time

    
    i typed it in like a minute bitch
    
    it will attempt to go back to baseline but no insults or alterations to brain structure or chemistry will leave absolute 0 everlasting effects, now imagine them accumulating over the years over time and you have alzhiemers/autism
18. 2018-03-28 at 10:02 AM UTC

    #4878
    RestStop Space Nigga

    Originally posted by lempoid loompus i typed it in like a minute bitch
    
    it will attempt to go back to baseline but no insults or alterations to brain structure or chemistry will leave absolute 0 everlasting effects, now imagine them accumulating over the years over time and you have alzhiemers/autism

    
    What are your thoughts on 5-htp as a supplement?
19. 2018-03-28 at 10:03 AM UTC

    #4879
    The Self Taught Man Black Hole
    BOOF IT!
20. 2018-03-28 at 10:07 AM UTC

    #4880
    

    NARCassist gollums fat coach

    Originally posted by Malice I have transcended the physical realm and become the Platonic ideal of autism.

    
    did plato have autism then?
    
    
    
    .