User Controls
Posts by BeeReBuddy
-
2020-07-06 at 9:43 PM UTC in funny thing just happened with that woman who said she was hungry earlierShe can be your Ghislaine Maxwell.
-
2020-07-06 at 9:28 AM UTC in Fona 7-6-2020Good morning.
Back to work today :(
but at least I am making money :)
High of 95F today and I just cant wait to get to the industrial park. Oh boy, how I can't wait :/
Hopefully everything goes smooth today.
I still have a lot to do before I have to leave for work so I better get to it.
Hope everyone is doing good.
TTYS -
2020-07-06 at 1:22 AM UTC in hat is it with netflix and all these polish movies all of a sudden?I AM SO GLAD YOU ARE BACK!
-
2020-07-06 at 1:21 AM UTC in Imagine just imagine if you were this guy... if this was your life…… 3======D
-
2020-07-06 at 1:20 AM UTC in Imagine just imagine if you were this guy... if this was your lifeshake it
-
2020-07-06 at 1:19 AM UTC in I'm converting to JPEG
-
2020-07-06 at 1:08 AM UTC in A - Z Drug Synthesis
Originally posted by Ghost Starting from Toluene.
"o-Toluidine can be synthesized from toluene. The direct aromatic amination is very effective when done with a parent nitrenium ion, but o-toluidine can also be synthesized in other ways. For example, by the amination of toluene with methylhydroxylamine or hydroxylammonium salts in presence of aluminum trichloride"
https://pubs.acs.org/doi/abs/10.1021/j150226a002
Once you have o-Toluidine you can proceed to start making the precursor
http://www.prepchem.com/synthesis-of-2-methylbenzenediazonium/
"100 ml of concentrated hydrochloric acid (1.2 moles) and 50 ml of water are poured into a 500 ml flask. 43 grams (or 43 ml) of o-toluidine (0.4 mole) are added and well mixed in order to convert the o-toluidine into the o-toluidine hydrochloride. The solution is cooled with shaking in a salt-ice bath and the o-toluidine hydrochloride separates as fine crystals. By keeping the mixture at a temperature of 0-5° C and by vigorous shaking in the salt-ice bath the o-toluidine hydrochloride is treated with a solution of 28 grams of sodium nitrite in 80 ml of water with shaking. The o-toluidine hydrochloride dissolves as the more soluble 2-methylbenzenediazonium diazonium salt is formed, and at the end of the addition of the sodium nitrite the solution should contain a trace of nitrous acid. 2-methylbenzenediazonium is not stable and should be consumed."
Then you can make 2-chlorotoluene
"The solution of cuprous chloride is cooled in an ice bath 0-5° C temperature. In this cold solution, the 2-methylbenzenediazonium is poured with constant shaking and allowing the mixture to come to room temperature. After about 10 minutes, the mixture gradually warmed with a good shaking. As the temperature rises the brown addition product begins to decompose with the evolution of nitrogen and with the formation of an oily layer of 2-chlorotoluene. When the decomposition reaction is at an end, the mixture is steam distilled, continuing the process only as long as oily droplets are present in the distillate, for the product is not appreciably soluble in water. The layer of 2-chlorotoluene is carefully separated and washed twice with an equal volume of concentrated sulfuric acid, which removes both the 2-cresol and the azo compound. Then 2-chlorotoluene is washed with water in order to remove the inorganic acid. Finally, 2-chlorotoluene is dried over calcium chloride, distilled, using an air condenser and collecting the product boiling at 153-158° C. Pure 2-chlorotoluene boils at 157° C. The yield is 25-30 g."
Then you make 2-chlorobenzaldehyde
http://www.prepchem.com/synthesis-of-1-chloro-2-dichloromethylbenzene/
And then you can make 2-chlorobenzoyl chloride
https://patents.google.com/patent/US4388251
"The present application is directed to the preparation of 2-chlorobenzoyl chloride by the reaction of 2-chlorobenzaldehyde with chlorine in the presence of phosphorus pentachloride"
The synthesis is nearly finished now and we just have to form the benzodiazepine ring structure
https://erowid.org/archive/rhodium/chemistry/clonazepam.html
"3. Clonazepam (5-(2-chlorophenyl)-1,3-dihydro-7-nitrobenzo(1,4)-diazepin-2-one)
(see swiss patent 580,087, workup: US patent 3,335,181)
The 143 g (0.36 mol) intermediate from step 2, 101 g hexamethylenetetramine (urotropine) and 36 mL 99 % formic acid are suspended/dissolved in 5 L absolute ethanol, the mixture is refluxed with stirring for 4 h, and then the mixture is concentrated in vacuo to dryness. The residue is dissolved in 2 L dichloromethane and 4 L water, the organic layer is seperated and mixed with 2 L ethanol. Over a 20 cm vigreux column, the dicloromethane is distilled off and the residual solution is cooled to 0 C for 24 h. The almost yellow-white crystalls of Clonazepam are vacuum-enhancemented off and washed with 0 C ethanol, after drying, about 90.9 g (80%) of Clonazepam are resulting, mp. 235-237°C."
bump -
2020-07-05 at 11:37 PM UTC in There is absolutely no reason for this!
The first result for white baby is a black baby.
wtf -
2020-07-05 at 10:54 PM UTC in Space Niggas who don't live with their motherelectricity is like $63 a month.
Its really hot in my apartment.
A lot hotter than my mom's basement. -
2020-07-05 at 9:18 PM UTC in Oldest living conjoined twins have stopped living.It's not gay if you have your brother do it.
-
2020-07-05 at 8:40 PM UTC in Oldest living conjoined twins have stopped living.
https://www.whio.com/news/local/ronnie-donnie-galyon-oldest-conjoined-twins-passed-away-this-morning/YZNPIR5RYJFZVDXCBBBSGJGGPI/
After spending 68 years joined at the dick to their brothers Mr. and Mr. Gaylon are no more.
RIP (2 pieces maybe) -
2020-07-05 at 8:35 PM UTC in My apartment is too hot.
Originally posted by A College Professor simped out by a a cat and khell yet again, but it occurrs to me that supposably you wear the pants . honestly none of it really makes any sense but i guess its just another one of your'e outbursts of false outrage..
You're right.
I do make more money than her.
Im buying myself a kegorator. -
2020-07-05 at 7:05 PM UTC in My apartment is too hot.The ac is blowing but it is in the bedroom.
The fan I have is not helping much because Chell is using it to keep the cat cool. -
2020-07-05 at 6:29 PM UTC in Brown Eggs or White Eggs?
-
2020-07-05 at 6:23 PM UTC in Brown Eggs or White Eggs?Did anyone figure out what color egg is best egg?
Im going to the store soon. -
2020-07-05 at 6:07 PM UTC in Fona 7-5-2020I have poured another glass of lemonade and played CS:GO.
I bet Bill Krozby would be really good at CS:GO. -
2020-07-05 at 4:42 PM UTC in Fona 7-5-2020Apparently we don't feel like doing anything today so we are not.
Chell did a load of laundry but a pen slipped into it and my washer had ink in it and im sure there is ink on my clothes.
I hope not.
I ate some taquitos, been drinking lemonade and smoking weed.
Life is good. -
2020-07-05 at 4:11 PM UTC in Counter Strike NIS Server Free to play SUPER FUN!
-
2020-07-05 at 5:50 AM UTC in Fona's July 4th 2020 Freedom SpecialI passed out in thighs and mostly rested all evening.
The fireworks was cool.
Now I am going to bed.
See you tomorrow. -
2020-07-04 at 9:02 PM UTC in Fona's July 4th 2020 Freedom SpecialI ordered me a Freedom Pizza.
