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Posts That Were Thanked by GGG
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2018-12-14 at 6:46 AM UTC in MarriageCongratulations, you're still going to die but it might not be alone. Make each other feel good, at least while it's still hip to be in love. I hope you don't live long enough to regret this.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-14 at 6:29 AM UTC in How do they get babies to cry for moviesThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-14 at 6:14 AM UTC in MarriageShe said yes o.O
now watThe following users say it would be alright if the author of this post didn't die in a fire! -
2018-12-14 at 4:36 AM UTC in Does anybody else notice that everybody who abused bundy as a teenager is essentially retarded?For what it's worth...
Neurotoxicity of dextrorphan
Ortiz GG1, Guerrero JM, Reiter RJ, Poeggeler BH, Bitzer-Quintero OK, Feria-Velasco A.
Author information
Abstract
BACKGROUND:
The noncompetitive NMDA antagonists phencyclidine (PCP) and dizocilpine (MK-801) have been considered for use as neuroprotective therapeutic agents, although both produce injury in neurons of cingulate and retrosplenial cortices in rodents. The low-affinity, noncompetitive NMDA antagonist dextrorphan has been considered for use as a neuroprotective therapeutic drug. The aim of the present work was to evaluate the neurotoxicity of dextrorphan.
METHODS:
Sprague-Dawley male rats were used and injected with either saline or dextrorphan (30 mg/kg i.p.). The animals were sacrificed 30 min later, and the brain was examined for histopathological changes.
RESULTS:
After systemic administration of the drug, hyperchromatic and shrunken nuclei with chromatin condensation and disruption were observed. Also, granular and vacuolated cytoplasm was apparent in pyramidal neurons in the retrosplenial (posterior cingulate) cortex. Status spongiosus (spongy degeneration) of the neuropil was also detected.
CONCLUSIONS:
Morphological changes are similar to those described previously, which are induced by high-affinity, noncompetitive NMDA antagonists, such as MK-801.The following users say it would be alright if the author of this post didn't die in a fire! -
2018-12-14 at 3:58 AM UTC in The meaning of life is to give life meaning.
Originally posted by Flatulant_bomb Why is everyone searching for the meaning of life? Just live niggas! You have life so LIVE! The fuck who cares what the meaning is?
That is kinda in line with what I was saying.
Intrinsic meaning is up for grabs.
But people do assign meaning in one way or another, just not necessarily consciously.
When you wake up, you (and everyone else) get out of bed for a reason.
That reason is the meaning of life.
It will differ on a case-by-case basis, but we all assign some kind of meaning to life as we know it.
So-called nihilists are really just un-self-aware frauds.The following users say it would be alright if the author of this post didn't die in a fire! -
2018-12-14 at 3:56 AM UTC in Happiness is an unrealistic goalHappiness has become an object of seductive nature used to control people like lemmings by referring them to a commercial mythology wherein their wishes are granted and their suffering is validated, if and only if they accept the prescriptions offered by the authorities. This project of subjugating the human spirit is so far along that the very concept is hardwired into our brains so that we enslave ourselves for them. Any hope of subverting the process ran out centuries ago, if not millennia. You'll never really be happy, but you'll keep trying, and that makes other, more powerful people satisfied for the time being.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-14 at 3:48 AM UTC in The meaning of life is to give life meaning.
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2018-12-14 at 3:16 AM UTC in When you're at the store buying liquor and walk into the 'mixer' aisleThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-14 at 2:09 AM UTC in When you're at the store buying liquor and walk into the 'mixer' aisle
Originally posted by GGG What are some brands you'd recommend?
Glenfiddich is decent.
I haven't tried every brand of Single Malt Scotch out there, admittedly.
In fact, I haven't even tried every type (they vary based on where in Scotland they come from).
But as a general rule, the more aged, the better, and single malt is always superior to blended scotch.
Other than that, personal taste will become a factor.
Some prefer Speyside single malts (such as Glenfiddich), whereas others prefer Islay or Highland brands.
Scotch is an interesting type of liquor, with a lot of history, and some pretentious zealots / over-the-top fanatics out there.
I sometimes can't even tell if they're just utterly full of it, or really able to distinguish between such subtle nuances as how floral vs how fruity a certain scotch is, or if it's slightly more nutty than it is malty.
Scotch enthusiasts can be pretty precise with their alleged flavor profiles.
Say what you want about me being a pleb or what have you, but I just like it aged well and single malt. Beyond that, those subtle nuances are beyond my palette's detection.The following users say it would be alright if the author of this post didn't die in a fire! -
2018-12-14 at 1:46 AM UTC in Seasonal Affective Disorder
Originally posted by Ghost Bisexuals are smart because they have an unlimited dating pool.
The ultimate combo is women/lolis/trannies though.
I'd probably proceed with extreme caution there.
There's having an unlimited dating pool, and then there's, you know, legal, ethical, and practical limitations.
Also, you forgot farm and jungle animals.
There be some fine ass female non-human primates. Bonobo bitches be fine as hell.The following users say it would be alright if the author of this post didn't die in a fire! -
2018-12-14 at 12:02 AM UTC in The worst thing you can tell someone who is not calm is...Calm down.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-14 at 12:01 AM UTC in What is tinder?dry, thin wood you use to get the fire startedThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-13 at 10:35 PM UTC in The girl in the pink dress from the "Friday" music video
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2018-12-13 at 8:40 PM UTC in ITT: We speak only mono-syllabicallyYou are all fake and just one of us is real, I think and eat and sleep and fuck and feel, so it must be me.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-13 at 7:41 PM UTC in If you had unlimited resourcesOr you could make your unlimited resources transparent and contribute to the betterment of our kind, a subject of discourse rather than a means of obtaining power, and become a shining example of altruism and restraint in human activity.
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2018-12-13 at 7:27 PM UTC in When you're at the store buying liquor and walk into the 'mixer' aisleThis nigga is lost in WalmartThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-13 at 6:40 PM UTC in Old white men make me sickWTF ever happened to lemmonparty?
It was the most happening party on the Internet.
If you can't explain what at least three of the following four things are, you did not spend enough time on the Internet earlier on (or are too young to have):
1. Goatse.
2. Lemmonparty.
3. Tubgirl.
4. 2girls1cup.
You may begin the exam now.
Pull out your scantron sheet and a #2 pencil. -
2018-12-13 at 6:24 PM UTC in The girl in the pink dress from the "Friday" music videoThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-12-13 at 5:59 PM UTC in Old white men make me sickDon’t click on that linkThe following users say it would be alright if the author of this post didn't die in a fire!
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I just called Geek Squad, Microsoft Tech Support, and my neighbour down the street who's always on the computer and is therefore "good at computers".
They're all on their way over to fix this.
It'll all be okay.The following users say it would be alright if the author of this post didn't die in a fire!