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Posts by the man who put it in my hood
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2021-07-22 at 6:59 PM UTC in STICK IT, Damn It!
Originally posted by stl1 Just a note: Most things of any value require more than a single word (as most of my posts show).
Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in cell cultures.13 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.14,15 Even though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) against SARS-CoV-2 in vitro.16-19 Subcutaneous administration of ivermectin 400 µg/kg had no effect on SARS-CoV-2 viral loads in hamsters. However, there was a reduction in olfactory deficit (measured using a food-finding test) and a reduction in the interleukin (IL)-6:IL-10 ratio in lung tissues.20
Since the last revision of this section of the Guidelines, the results of several randomized trials and retrospective cohort studies of ivermectin use in patients with COVID-19 have been published in peer-reviewed journals or have been made available as manuscripts ahead of peer review. Some clinical studies showed no benefits or worsening of disease after ivermectin use,21-24 whereas others reported shorter time to resolution of disease manifestations that were attributed to COVID-19,25-27 greater reduction in inflammatory marker levels,26 shorter time to viral clearance,21 or lower mortality rates in patients who received ivermectin than in patients who received comparator drugs or placebo.21,27
However, most of these studies had incomplete information and significant methodological limitations, which make it difficult to exclude common causes of bias. These limitations include:
The sample size of most of the trials was small.
Various doses and schedules of ivermectin were used.
Some of the randomized controlled trials were open-label studies in which neither the participants nor the investigators were blinded to the treatment arms.
Patients received various concomitant medications (e.g., doxycycline, hydroxychloroquine, azithromycin, zinc, corticosteroids) in addition to ivermectin or the comparator drug. This confounded the assessment of the efficacy or safety of ivermectin.
The severity of COVID-19 in the study participants was not always well described.
The study outcome measures were not always clearly defined.
that doesn't prove or disprove anything. You aren't a doctor.
Nobody here is a doctor and there is an unlimited amount of studies that disprove each other endlessly because science only gets done when someone pays for it. You are just playing into the agenda.
You know you fucked up when you fall into media conventions PEOPLE ARE ARGUING ABOUT IVERMECTIN SO I MUST ARGUE ABOUT IVERMECTIN IF THEY ARE AGAINST IT THAT MUST MEAN I SHOULD BE FOR IT
This stopped being about science, public health and safety long ago. None of you people give a shit about any of that and are just co-opting this disaster into your political narrative. -
2021-07-22 at 6:48 PM UTC in Chimpanzees are killing gorillas unprovoked for the first time: scientists
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2021-07-22 at 6:43 PM UTC in STICK IT, Damn It!
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2021-07-22 at 6:40 PM UTC in What are you doing at the momentall that buckwheat made him weak
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2021-07-22 at 5:59 PM UTC in Chimpanzees are killing gorillas unprovoked for the first time: scientistsblack on black crime
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2021-07-22 at 5:58 PM UTC in Luring cops to their doom with calls about someone smoking weeduh huh uh huh
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2021-07-22 at 5:57 PM UTC in How do you attach a sink to a counter at the bottomNo, still haven't called him i'm too lazy
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2021-07-22 at 5:57 PM UTC in I hate being oldits summer
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2021-07-22 at 4:54 PM UTC in Brits experimenting with corona powered aircraft to cause rain in miserable dry arab shitholejust make more water
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2021-07-22 at 4:47 PM UTC in guys... guys...who?
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2021-07-22 at 4:39 PM UTC in the benefits and downsides of being singl
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2021-07-22 at 4:39 PM UTC in I hate being oldi wanna freeze to death
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2021-07-22 at 4:39 PM UTC in this is so sadI am not into them. most people just do that with the switch online nowadays
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2021-07-22 at 4:38 PM UTC in Why is beeno flooding my PM with spamApparently you get less time if you don't use a mask and don't threaten anyone. Just politely ask for the money and you save 5 years off your charge
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2021-07-22 at 4:37 PM UTC in I don't live in Omahaokay berkley billy
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2021-07-22 at 4:36 PM UTC in We're about to lose our English members
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2021-07-22 at 4:29 PM UTC in We're about to lose our English membersI fucking hate British people they piss me off
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2021-07-22 at 4:29 PM UTC in We're about to lose our English membersGood I hate all of them not a single good one
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2021-07-22 at 4:28 PM UTC in Tell us a funny story/event
Originally posted by Quick Mix Ready I'm sorry, son. You have to have life experiences it seems to share
school story: before they got the firewall in elementary school I put a bunch of porn on computers and deleted everything in the folder you upload your projects to. There was some oversight, a loose thread and I just kept pulling on it.
after lunch time I got called down to the computer room OH SHIT and every kid in the school that had the same first name as me from every grade was also there. They only knew the first name and said "whoever it is I want you to admit it"
I don't know how the fuck they couldn't prove it was me. a few of the kids were first graders and didn't even know how to turn on a computer.
I got into lots of trouble with computers and did stuff like print 999 copies of hitler on every public printer. I would steal the login credentials of kids I didn't like and erase all their shit off the school server
thats my funny story -
2021-07-22 at 4:17 PM UTC in Tell us a funny story/eventokay I just went out to get muffins and some guy smoking a cig as I walked by started to say HEY HEY HEY YOU!
but he waited until I have to look behind me and I never look behind me or stop for anyone no matter what which makes some people very angry. He started yelling and shouting and a lady stopped because he was REALLY loud and she was like ARE YOU OKAY SIR and he just kept ranting
I was already around a corner. I looked back at the woman only
Also when he said hey to me I said FUCK YOU and kept walking lmao.