No, but they added a leveling system in SCII which is useful during PvP
The main reason I was considering it was because if you take it at night, you have reduced endegenous opiod levels while you sleep, and then by the time you're awake you have more endegenous opiods in your system than you normally would because of the rebound effect. It would be a novel sort of antidepressant.
Sertraline was taken in the morning and mirtizapine at night, that way they don't cancel each other out. One stimulates, one sedates. I'm assuming the 12 hour period between each dose is enough time to reap the benefits of the specific chemical before they would poop out on each other.
I remember reading something about how atomoxetine enhances choline production and efficacy but I can't find the article at the moment, I'll post it when I do.
About antipsychotics messing up the binding, on the other hand the lower amount of binding on the receptors not bound by antipsychotics could lead to "more efficient neurosculpting" or something like that, because the receptors that get bound to by antipsychotics first I assume are the less critical "pores", since something must determine which sites and bound to before others when the neurotransmitter is the same. It could have a diluting or potentiating effect, can't say for sure.
bite your hands off to release tension
What would your opinion on the long term use of antipsychotics for cognitive enhancement alongside the treatment of schizophrenic/schizotypal symptoms?
Almost all atypicals do good things for the brain; protecting neurons from excitotoxicity, attenuating damage caused by ischemic strokes, reducing microglial activation, increases in brain-derived neurotrophic factor and nerve growth factors, antioxidant activities, reducing memory deficits induced by PCP and dopamine receptor damage from methamphetamine, etc... but at the same time they also cause brain tissue shrinkage over time, which has been associated with the course of psychotic disease but also with antipsychotic treatment itself. As well as tardive dyskinesia which could be permanent, and metabolic side effects.
Do you think being on a sizable dose of antipsychotics for an extended period of time would do more good than harm or more harm than good for someone who isn't outright hallucinating UFOs and shit?
For a while I had my nootropic regimen down pretty well: sertraline for enhanced 5ht signaling and therefore neurogenesis, mirtizapine promoting neurogenesis by indirectly affecting 5ht due to the related catchetolamine norephinephrine being affected which also might play some role, valproic acid which grows GABAergic interneurons which can help control faulty or overexcited signals, and is a powerful inducer of ERK-pathway related nerve growth, aririprazole for the positive effects of antipsychotics with a reduced chance of tardive dyskinesia and some mild euphoria due to the partial dopamine agonism, and dextroamphetamine which I think worked synergistically with the sertraline and mirtizapine (SSRI and NaSsa) for the release of additional catchetolamines, as well as dextroamphetamine's effect on dedritic sprouting.
Now I'm only on bupropion 100mg which sadly reduces BDNF levels but prevents neurogenesis reductions in mice induced by chronic restraint stress which is supposed to analogous to stress in humans, overall it has a brain-friendly effect and feels sort of like cocaine so it's worth it, 50mg of lamictal as a mood stabilizer, valproic acid would be better for the purpose of brain growth but it can also cause baldness and shit like that, but it still helps. Now I'm getting put on risperdal because I talked about how ashley deserves to die and I mentioned that I go telepathic sometimes chu no. Apparently the most effective atypical for psychosis, I'm unsure if that's due to nerve promoting effects or it's a high efficacy dopamine antagonist and that's about it. Also have a multivitamin and 6000mg of fish oil every day keep my networks WD-40'd.
Toxic psychiatric medication wishlist:
Wellbutrin + Strattera + Abilify + Buspirone + Lamictal + Low dose naloxone (look it up, think rebound effects) + Sertraline
I'll make her more fappable once I buy lingerie armor
2015-08-31 at 11:47 PM UTC
in
Attack doses of antipsychotics
It only has a D2 receptor occupancy around 50% at 600mg IIRC. Mostly serotonin receptor effects which contribute to psychosis as well, I'm assuming primarily the 5ht2a receptor for positive symptoms and 5ht1a can induce anxiolysis
2015-08-31 at 11:07 PM UTC
in
Attack doses of antipsychotics
I was on 200mg a day when I was 14 so my body might have grown accustomed to it. It's considered a relatively gentle antipsychotic, but I also might have pre-desensitized my histamine receptors with benadryl, that causes a lot of shitfeels.
2015-08-31 at 10:54 PM UTC
in
Attack doses of antipsychotics
Two days into my 600mg/day regimen and I'm able to actually relax. Surprisingly it makes you feel pleasantly stoned throughout the day, I'm not getting the massive akathisia that anti psychotics usually cause.
2015-08-31 at 7:30 PM UTC
in
Had another spice overdose
My mom was putting ice on my head and slapping my face and I was unresponsive, I was probably completely anesthetized because I don't remember anything after taking the hit.
2015-08-31 at 7:28 PM UTC
in
Had another spice overdose
The friendly crack dealer up the block leaves spice joints out for me occasionally because we're bros. I took one hit and held it in for probably 20 seconds and immediately hallucinated a voice telling me "You held that hit in for way too long" in an ominous tone. I did, I puked and spit out all sorts of shit over my kitchen floor while having heart palpitations and I screamed HELP ME over and over and my mom and my uncle who lives a few houses away came over and cleaned up my vomit while deciding whether they should call an ambulance or not. Then I went catatonic on the floor. They didn't and I passed out on my bed for the rest of the day. Having seroquel and fish oil to repair any damage I might have caused. It's weird how whenever I puke on spice I cough up this nasty tasting stuff that's like pure bitterant chemicals. I only took one hit and now I lost the joint, damn I want to find that joint that was some good shit.
Would it be more effective to take 200mg of seroquel over 5 days or 1000mg at once? I wonder if it's possible to cure psychosis with a high dose of antipsychotics flooding the brain at once. I'm thinking maybe when my dopamine receptors are a bit cooled down from antagonism I won't be ready to blurgleblurgleshrumblgle
