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Posts That Were Thanked by mmQ
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2018-01-06 at 6:28 PM UTC in The Retarded Thread: Get Rekt, Faggot!The following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-06 at 9:04 AM UTC in Killing yourself with nothing whatsoeverThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-06 at 9 AM UTC in Killing yourself with nothing whatsoeverhttps://www.sbs.com.au/nitv/article/2016/04/13/who-killed-malcolm-smith-must-see-film-about-deaths-custody
this guy - turns out he wasn't famous for painting, he was famous because his magic trick was one of the catalysts for investigation into the sheer number of aboriginal deaths in custody (turns out the only reason why there were so many aboriginal deaths in custody was just because there was a correspondingly high number of aboriginals in custody overall).Wootten investigated the death of Malcolm Charles Smith, a 28-year-old aborigine who died in January, 1983, in Sydney's Long Bay prison after he stuck a paint brush into his brain through his eye socket.
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2018-01-06 at 7:09 AM UTC in Killing yourself with nothing whatsoeverOoh. Could you grow your hair long, rip it out in chunks, and then cram it down your throat until you choke to death? Seems like the best option to me.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-05 at 7:50 PM UTC in What's the grossest thing you ever ate intentionally?PussyThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-05 at 5:42 PM UTC in Sobriety kinda sucksThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-05 at 8:40 AM UTC in Dargo is a snitching little faggot cuntMake me a meme too Douglas Craighead Monks the third hheeeerrrrr
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2018-01-05 at 7:12 AM UTC in Dargo is a snitching little faggot cuntThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-05 at 6:32 AM UTC in Why won't Lanny make the background space?actually I may start on making the arrow keys thing worse, like it will randomly change page for no reason, just for saying that.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-05 at 6:11 AM UTC in Florida being this cold is an affront to God
Originally posted by mmQ This makes me wonder why you guys are so hard on Bill Krozby but Nice to me, When in a sense, me and Bill Krozby have sort of been in the same boat and still are, despite our obvious personality differences.
Because Bill Krozby refuses to learn anything about anything, or discuss anything about anything. I don't really have a personal issue with him, it's just retarded when he posts a video with a vaguely smart sounding title, then evades any attempt to actually engage him on the subject and reverts into childish insults, for example.The following users say it would be alright if the author of this post didn't die in a fire! -
2018-01-05 at 5:58 AM UTC in Florida being this cold is an affront to God
Originally posted by mmQ Tru tru. I was in fact aware of the tilting as far as the main contributor to the seasons, just didn't ever figure the distance part was sort of opposite to what seems more obvious or logical or whatever. Close = hot and vice versa.
I am learning that I am quite not knowledgeable in anything. I just have a basic bitch understanding of most things but I don't have any good area of actual expertise other than maybe .. like… Fuck. I don't know. General street smarts? Getting a lot of references?
Jesus Christ. I don't have a single thing that I could SCHOOL someone in. Not that I can think of anyway.
FUUUUUUUUCK I really have wasted my life to addiction. What a joke. I mean, I'm smiling right now, but shit. Maybe that's why I just rely on comedy. Maybe that's all I have.
Mate, just find something that interests you and delve into it. There's a broad ocean of subjects that you can explore.
The reason why I was so anti-drug for so long is best stated by Randy here:
I've come to a middle ground now where I realize you can do drugs in moderation and be fine, but the basic point I'm trying to make is, the reason people get drunk and high and shit is because there's a part of your brain that's thirsting for you to be interested in something. Inebriation shuts it up, but you can also try to listen to it and feed it something interesting.
And it's never too late to start something, unless you're dead. But then you're not going to be around to care.The following users say it would be alright if the author of this post didn't die in a fire! -
2018-01-05 at 5:05 AM UTC in The Retarded Thread: Get Rekt, Faggot!
Originally posted by mmQ Also, I'm going to ask again. It's just a chance for someone to give me a fun little analogy explaining what GABA is and how it affects us?
I'd like to know why , again, my psychiatrist doesn't ask me about it or mention it. How IMPORTANT IS IT?
FUCK. The term gets brought up around here so much I figured someone would chomp at the bit to explain it to me and flex their ego a little bit. What's wrong with you guys? Lol
GABA is a type of neurotransmitter in the brain. Neurotransmitters can be thought of as the vehicle which drives chemicals from point A to point B. They facilitate the ability to help humans process everything that makes us run. Adrenaline, oxytocin, testosterone, alcohol... they are all dependent on neurotransmitters.
Your GABA receptors process a few different drugs. Alcohol, benzos, phenibut. But they don't all run through the same GABA receptors. Alcohol, for instance, runs through GABA-a. Phenibut runs through GABA-b. Despite this, a few of them have cross-tolerance.
Most GABA agonists that people do recreationally metabolize via the CYP450 enzymes, which basically act as a defense against the drug and aid your liver in getting rid of it, basically treating it as the intruder it is. Some people have a gene which makes them produce too many CYP450 enzymes, and thus it takes more for them to say, get drunk. Others have too little, and they get drunk very easily. There are different genes at play here, so you might have like, someone who produces waaay too much and thus gets seemingly no effect from opiates. That one is actually somewhat common.
Why is this important? Because so many GABA drugs metabolize via CYP450, they drain the available enzymes, leaving people with too little and thus making them get extremely fucked up. This is why downing 400 bars before your drinking session is a bad idea. It potentiates the alcohol and makes it easier to overdose on alcohol through respiratory depression or whatever (see: Not breathing.) When you combine a GABA drug like alcohol with something else that causes NOT BREATHING, like morphine, they both become far more potent than they would be if you take a drug alone. This is why mixing depressants is dangerous. People are idiots and just take their normal dose and die.
GABA has been linked to things like the production of melatonin and insulin. Now, your GABA levels aren't really linked to enzyme levels, but banging on your receptors like GABA agonist binges tends to do leaves them all beat up and unable to process whatever chemicals it needs to as well. This usually heals over time unless you are taking neurotoxic damage by consuming certain drugs or by consuming too much of a certain drug. Neurotoxicity basically means the receptor is damaged forever and will never work the same as it used to.The following users say it would be alright if the author of this post didn't die in a fire! -
2018-01-05 at 4:58 AM UTC in The Retarded Thread: Get Rekt, Faggot!why does anyone need to confirm the accuracy im a fucking neurosci textbook
gabapentin is a prodrug of the GABA molecule, but doesn't work as a GABAergic in the brain, instead its a calcium channel blocker highly specific to the a a2 subunit, and drugs that affect that subunit are called gabapentinoids. calcium is also an element used in neuron transmission and is also excitatory, so blocking this has an inhibitory effect, but is different from GABA and has different effects, even though they're similar in some ways since they're both depressants (reduce neurotransmission), the same way opiates are vaguely similar to alcohol because they're both depressantsThe following users say it would be alright if the author of this post didn't die in a fire! -
2018-01-05 at 4:49 AM UTC in The Retarded Thread: Get Rekt, Faggot!GABA is the main inhibitory neurotransmitter in the human body, glutamate is the main excitatory transmitter
more GABA = less brain activity/depressant
more Glutamate = more brain activityThe following users say it would be alright if the author of this post didn't die in a fire! -
2018-01-04 at 11:06 PM UTC in Sobriety kinda sucksThe following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-04 at 8:26 AM UTC in Donald Trump is legitimately mentally retarded.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-03 at 5:40 AM UTC in Couple Nabbed For X-Rated Romp In Texas EateryFYI bill talks about glitter and this is where he lives..
4:20 is billThe following users say it would be alright if the author of this post didn't die in a fire! -
2018-01-03 at 4:41 AM UTC in The Retarded Thread: Get Rekt, Faggot!
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2018-01-02 at 6:24 AM UTC in I denied God today.One day you'll wake up and your lack of belief will have failed to insulate you from the world. You'll look around and see theists smiling and drinking wine and realize their idiocy for wisdom, and you'll join them and then you'll die and burn because their God was the wrong one.The following users say it would be alright if the author of this post didn't die in a fire!
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2018-01-02 at 2:25 AM UTC in The Retarded Thread: Get Rekt, Faggot!The following users say it would be alright if the author of this post didn't die in a fire!
