The retarded thread: Fuck, §m£ÂgØL made one first edition

1. 2017-01-15 at 1:24 AM UTC

   #7361
   

   bling bling Dark Matter
   nood hash is legit
2. 2017-01-15 at 3:37 AM UTC

   #7362
   The Self Taught Man Black Hole
   gave myself serotonin syndrome again
3. 2017-01-15 at 4:17 AM UTC

   #7363
   The Self Taught Man Black Hole
   im getting smash my own head in feels
4. 2017-01-15 at 4:40 AM UTC

   #7364
   

   Lanny Bird of Courage
   Was just playing a CS match and at the end some 12 year old kid screamed in to the mic "WHERE ARE MY TENDIES, REEEEEE"
   
   I didn't realize the breadth of the meme.
   
   I feel a little betrayed
5. 2017-01-15 at 5:24 AM UTC

   #7365
   The Self Taught Man Black Hole
   u all cowardd si l sell fent on the side to lcoclasl
6. 2017-01-15 at 5:48 AM UTC

   #7366
   The Self Taught Man Black Hole
   g
7. 2017-01-15 at 6 AM UTC

   #7367
   The Self Taught Man Black Hole

   Originally posted by cerakote taking big drags off of menthol cigarettes does that to me while im drunk
   
   i remember the time when i ate a whole bag of takis and drank a can of chelada along with some other shitty beer and when i came back in from smoking i yacked red shit everywhere, it looked like i brained someone with a hammer and threw it all over my carpet
   
   that was a rough night

   
   Menthol cigarettes are the fucking worst. Cigarettes are bad enough, but anybody who smokes menthol cigarettes is a total fucking meat flap.
8. 2017-01-15 at 6:30 AM UTC

   #7368
   Malice Naturally Camouflaged

   Originally posted by Discount Whore Menthol cigarettes are the fucking worst. Cigarettes are bad enough, but anybody who smokes menthol cigarettes is a total fucking meat flap.

   
   IIRC menthol actually considerably upregulates nicotinic receptors.
9. 2017-01-15 at 7:07 AM UTC

   #7369
   Malice Naturally Camouflaged
   Aww, sweet, dhgate is giving out $3-$25 credit per day until the 17th. Won $8 today. Spin the wheel: http://www.dhgate.com/activities/promotion/annual-review.html
   
   They also regularly have coupons that can let you save $10 or so. Just need to wait for that bong to get back in stock.
10. 2017-01-15 at 8:05 AM UTC

    #7370
    The Self Taught Man Black Hole

    Originally posted by Malice IIRC menthol actually considerably upregulates nicotinic receptors.

    
    does that mean i can use menthol cough drops and vaporub as a cognitive enhancer??????/
11. 2017-01-15 at 8:49 AM UTC

    #7371
    Malice Naturally Camouflaged
    It's possible, but vaporizing a solution with menthol, which you can guy crystals of, would be the most efficient method.
12. 2017-01-15 at 8:53 AM UTC

    #7372
    The Self Taught Man Black Hole
    that sounds awful
    
    i bet it would be more pleasant sucking on x quantity of ricola every day
    
    i've also read that menthol potentiates the nicotine but i don't know if its due to receptor upregulation. too lazy to google right now.
    
    and what does increased nicotinic receptor expression translate to? enhanced acetylcholine function? what benefits would this theoretically have?
    
    if this actually makes sense it'll be a new reddit thing to add coughdrop bundies to their stacks
    
    menthol has other pharmacological and probably minor properties like enhancing GABAA currents as a positve allosteric modulator
    
    Post last edited by the holy ghost at 2017-01-15T08:56:55.574787+00:00
13. 2017-01-15 at 9:05 AM UTC

    #7373
    The Self Taught Man Black Hole

    Prolonged cigarette smoking is associated with an increase in nACh receptor density throughout the brain (Picciotto and Kenny, 2013). This process of receptor “up-regulation” is likely to play an important role in the physiological underpinnings of nicotine addiction.

    
    so menthol upregulates the same way nicotine does, through desensitization and rebound effect. from what i can tell menthol inhibits nicotinic signaling so it actually doesn't potentiate the effects, but instead causes long term changes in the receptor which contribute to addiction. does chronic nicotine administration benefit people? my common sense would say no, but who knows, maybe people who vape pure nicotine constantly are slightly mentally sharper. another interesting thing to consider is that if you use enough menthol to upregulate your nicotine receptors, you could get possibly end up habituating menthol the same way people habituate nicotine.
14. 2017-01-15 at 9:10 AM UTC

    #7374
    Malice Naturally Camouflaged
    Lace your wholesome weed with whole tobacco alkaloid extract.
15. 2017-01-15 at 11:39 AM UTC

    #7375
    The Self Taught Man Black Hole
    WHERE IS MY TECH REEEEEEE
16. 2017-01-15 at 11:40 AM UTC

    #7376
    The Self Taught Man Black Hole
    I used to huff menthol
17. 2017-01-15 at 4:04 PM UTC

    #7377
    The Self Taught Man Black Hole
    Jumanjiii
    
    What a movie. All time great
18. 2017-01-15 at 4:39 PM UTC

    #7378
    

    bling bling Dark Matter
    menthol itas a drug
19. 2017-01-15 at 5:38 PM UTC

    #7379
    The Self Taught Man Black Hole
    Days and weeks go a lot slower when you're mostly sober
20. 2017-01-15 at 5:40 PM UTC

    #7380
    The Self Taught Man Black Hole

    Originally posted by reject Days and weeks go a lot slower when you're mostly sober

    
    i get used to it after day 4 or 5