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Seriously scron
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2023-12-08 at 11:27 AM UTCYou need to tey the real east European mephedrone. Your dick will fall off from masturbarion or hitting it.
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2023-12-08 at 12:14 PM UTCmcat drugs are kinda meh i;;l make a pound one day its not hard
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Notes on the Synthesis of Methcathinone
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Author: Anonymous <nobody@replay.com>
Date: 1997/07/10
Oxidation of sec-alcohols to ketones using Sodium Hypochlorite
(reprinted & edited from a former post to alt.drugs.chemistry)
(I DID NOT DEVELOP THIS PROCEDURE NOR HAVE I TRIED IT. I HAVE MY OWN DOUBTS
ABOUT IT, BUT DO TO SOME INTEREST I'VE DECIDED TO REPOST THE INFORMATION.
TRY IT AT YOUR OWN RISK AND $$. IF YOU GET IT TO WORK, PLEASE LET THE REST
OF US KNOW.)
2.62 g of (pseudo)ephedrine HCl was dissolved in 11.6 g glacial acetic acid
in a 100 ml beaker equipped with a magnetic stirrer. 20 g of 5.25% sodium
hypochlorite solution (Regular Chlorox) was added slowly with stirring. The
mixture tested positive to starch iodide paper.
Stirring was continued for 1 hour then sufficient saturated sodium sulfite
solution (9.6 g) was added to produce a negative starch iodide test. 50 ml
of saturated sodium chloride solution and 15.5 g of ice was added and the
solution basified with 50% sodium hydroxide solution (16.7 g). At this
point a white precipitate formed and a sweet odor indicative of ketone was
observed.
The slurry was extracted with 1x75 ml then 2x50 ml chloroform. The organic
phase was dried over sodium sulfate, enhancemented, and evaporated to yield 2.51
g of slightly yellowish waxy crystalline solid. This was dissolved in 100
ml hot hexane and decanted from a small amount of insoluble material.
[editor's note: the yellow color might be due to the hitherto discussed CAT
dimer byproduct]
Excess HCl gas was bubbled through the hexane solution to form a white
precipitate. This was enhancemented, washed twice with ether and dried to yield
2.25 g (86% yield) of slighly off-white powder with a MP of 161-171 C.
The crude product was recrystallized from alcohol-ether, enhancemented and
washed with cold ether to yield a bitter white powder with a MP of 179-180
C (final yield 74%).
CONCLUSION:
Melting point of the final product is consistent with methcathinone HCl
(lit. 182-184 C). It appears that the oxidation of sec-alcohols to ketone
using sodium hypochlorite originally reported in JOC 45 (1980): 2030ff can
be successfully applied to amines. This procedure is superior to the more
traditional chromate & permanganate oxidations in a number of ways,
including cost of reagents, no hazardous waste generation, and the easier
product isolation resulting from lack of unwanted precipitates in the
reaction mixture.
[editor's note: My reservations about the above post come from the fact
that it looks almost exactly like a combination of the permanganate method
published by Zhingel et al. in J. Forensic Sci. 36 (1991): 915-20 (this is
in the Methcathinone FAQ 2.2, towards the end of the FAQ.) and the
hypochlorite method of oxidizing alcohols I've seen in a number of recent
organic chemistry laboratory textbooks. The original poster may just have
replaced the steps in the permangante method, with those from the
hypochlorite method. Of course, this may be exactly how the original poster
developed a synthetic protocol that maybe does work.]
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2023-12-08 at 2:51 PM UTC
