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Niggas in Space > Better Living Through Chemistry > If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be
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If you haven't had an intense psychedelic trip, you have no idea how powerful the mind can be

  1. 2018-11-29 at 4:49 AM UTC
    #41
    mashlehash victim of incest [my perspicuously dependant flavourlessness]
    I should know about too much dopamine
  2. 2018-11-29 at 4:51 AM UTC
    #42
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Originally posted by GGG I like the GABA idea. GABAgadzooks. GABAg

    I was trying to find this information on an opiate that was apparently non-psychoactive but still had some pretty decent analgesic properties. Can't find shit tho. Idk if anyone knows what I'm talking about, but I really wanna look at the mechanism for that right now. I really need to start taking notes.

    While the application is years away, the theory is open to all kinds of possibilities.

    I've always wanted to try an opiate / hallucinogen (psilocybin or LSD, most likely) combination, but I can't anymore because I swore off opiates 4 years ago.
  3. 2018-11-29 at 5 AM UTC
    #43
    mashlehash victim of incest [my perspicuously dependant flavourlessness]
    What Happened?
  4. 2018-11-29 at 5:01 AM UTC
    #44
    GGG victim of incest [my veinlike two-fold aepyornidae]
    Originally posted by gadzooks Oh, and drug tolerance of any kind whatsoever… L to the O to the L.

    We won't be having any of that now.

    We could go the route of kava and add reverse tolerance. I believe the kavalactone responsible for this is kavain, which is an allosteric something something something something. It increases the amount of receptor sites though, which is pretty fucking interesting when you think about it. Imagine your drug addiction getting CHEAPER over time.
    The following users say it would be alright if the author of this post didn't die in a fire!
  5. 2018-11-29 at 5:02 AM UTC
    #45
    mashlehash victim of incest [my perspicuously dependant flavourlessness]
    Receptor site increasing drugs sound spectacular.
    The following users say it would be alright if the author of this post didn't die in a fire!
  6. 2018-11-29 at 5:20 AM UTC
    #46
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Originally posted by mashlehash What Happened?

    Full blown IV-heroin addiction.

    Got to a point where there was no turning back.

    Haven't taken so much as a Tylenol-3 (Codeine) since 2014.
  7. 2018-11-29 at 5:20 AM UTC
    #47
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Originally posted by GGG We could go the route of kava and add reverse tolerance. I believe the kavalactone responsible for this is kavain, which is an allosteric something something something something. It increases the amount of receptor sites though, which is pretty fucking interesting when you think about it. Imagine your drug addiction getting CHEAPER over time.

    Yeah that is a really interesting phenomenon, and it just goes to show the potential to engineer drugs and drug receptors to behave similarly with other drugs.
  8. 2018-11-29 at 5:45 AM UTC
    #48
    GGG victim of incest [my veinlike two-fold aepyornidae]
    It's kind of hard for me to imagine a brain developing MORE receptor sites. You'd think "Hey, you got what you got" but somehow the body can just make more?

    Like when I imagine this I'm thinking of all the little axon ends poopin up 3d models of drugs. Then suddenly receptors begin sprouting out of the base of your brain like a forest. Their rounded, cuppish hands grasp like peasants at their king as they scream and beg for more drugs.

    Seriously though where the fuck does the matter for this come from? Have the receptors always been there, just waiting to be activated? Is the brain repurposing transmitter sites? Da fuqs goin on
  9. 2018-11-29 at 5:48 AM UTC
    #49
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Originally posted by GGG It's kind of hard for me to imagine a brain developing MORE receptor sites. You'd think "Hey, you got what you got" but somehow the body can just make more?

    Like when I imagine this I'm thinking of all the little axon ends poopin up 3d models of drugs. Then suddenly receptors begin sprouting out of the base of your brain like a forest. Their rounded, cuppish hands grasp like peasants at their king as they scream and beg for more drugs.

    Seriously though where the fuck does the matter for this come from? Have the receptors always been there, just waiting to be activated? Is the brain repurposing transmitter sites? Da fuqs goin on

    Lol, dude, that's EXACTLY what it does...

    I took a whole 4th year (undergrad) special topics class on LTP (Long-Term Potentiation - basically, the biology of memory).

    I did an entire project and half hour lecture on dendritic spine remodeling.

    Dendritic spines are the connectors that sprout and connect to other neurons.

    This stuff ain't science fiction.
    The following users say it would be alright if the author of this post didn't die in a fire!
  10. 2018-11-29 at 5:49 AM UTC
    #50
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    The following users say it would be alright if the author of this post didn't die in a fire!
  11. 2018-11-29 at 5:52 AM UTC
    #51
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Originally posted by GGG Seriously though where the fuck does the matter for this come from? Have the receptors always been there, just waiting to be activated? Is the brain repurposing transmitter sites? Da fuqs goin on

    The brain is constantly manufacturing, and tearing down, neurotransmitter receptors. It has tiny little robot-like molecular machines that work like a factory to convert between macromolecules, and then to move these new macromolecules (the receptors) to where they need to be.

    I'm not kidding.

    It sounds weird as fuck, but that's how it works.
  12. 2018-11-29 at 6:09 AM UTC
    #52
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Here's one example. I tried to find the simplest one I could. There are a lot of biochemical reactions occurring in receptor up/down-regulation and dendritic spine remodeling, so it's very hard to simplify it.

  13. 2018-11-29 at 6:12 AM UTC
    #53
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Essentially, signals tell genes inside of neural cells (via a cascade of chemicals), which instructs the cell to start producing the macromolecule/protein using the DNA as a blueprint. This new macromolecule/protein (the new receptor) is then sent to the synapse to be "installed", if you will.
  14. 2018-11-29 at 6:17 AM UTC
    #54
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    And this pic is from the a paper that refers to the "Sushi Belt" hypothesis.

    One thing I especially want you to note, though, is where I drew the purple circle around that thing that looks like it has legs.

    It's a microscopic molecular structure that essentially "WALKS" to carry molecules to where they need to go.

    The following users say it would be alright if the author of this post didn't die in a fire!
  15. 2018-11-29 at 6:18 AM UTC
    #55
    GGG victim of incest [my veinlike two-fold aepyornidae]
    That 3d modeling is sexy as fuck.

    So the dendritic spines DO just pop up then? That's absolutely insane.
    The following users say it would be alright if the author of this post didn't die in a fire!
  16. 2018-11-29 at 6:19 AM UTC
    #56
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    And people always asked me why I majored in psychology.

    It's not all about Freud and diagnosing mental illness.

    It is an incredibly vast composite field with lots of different areas of research.
  17. 2018-11-29 at 6:21 AM UTC
    #57
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Originally posted by GGG That 3d modeling is sexy as fuck.

    So the dendritic spines DO just pop up then? That's absolutely insane.

    Yeap, it fucking is insane.

    I mean, complex biochemical reactions "build" the dendritic spines, but essentially they just "pop up."

    Neuroscience is fucking fascinating.

    Fuck, now I miss being in school.

    I want to go back (to grad school though).
  18. 2018-11-29 at 6:23 AM UTC
    #58
    GGG victim of incest [my veinlike two-fold aepyornidae]
    Do you have a link to that sushi belt hypothesis article? Do you know what the little robot things are called? I've got massive cum stains in my pants right now.
    The following users say it would be alright if the author of this post didn't die in a fire!
  19. 2018-11-29 at 6:23 AM UTC
    #59
    GGG victim of incest [my veinlike two-fold aepyornidae]
    Fuck why does my night have to end when I'm about to go on a research binge
  20. 2018-11-29 at 6:26 AM UTC
    #60
    gadzooks Dark Matter [keratinize my mild-tasting blossoming]
    Originally posted by GGG Do you have a link to that sushi belt hypothesis article?

    https://www.ncbi.nlm.nih.gov/pubmed/21878995

    PDF available for download too.


    Originally posted by GGG Do you know what the little robot things are called? I've got massive cum stains in my pants right now.

    Fuck I am trying so hard to remember, because there's even a YouTube video that models it doing it's "walking" thing and it's trippy as fuck.
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