Who here is well versed in pharmacology/pharmacodynamics?

1. 2018-09-16 at 1:14 PM UTC

   #41
   

   Grimace motherfucker [my enumerable hindi guideword]
   Cash me outside, §m£ÂgØL. Cash me in my inbox.
2. 2018-09-16 at 3:23 PM UTC

   #42
   

   Glokula's Homabla African Astronaut

   Originally posted by DietPiano Oxycodone.

   
   well then that indication isnt based on logic is it? the most reasonable first line would be bupe. bupe has a higher molecular weight than oxy so less permeability and isnt very orally bioavailable. im researching opiates with the highest molecular weights that dont work orally rn to see if its possible to use an opiate that doesnt pass through breastmilk at all.
   
   also i found this which is interesting https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153123/
   The following users say it would be alright if the author of this post didn't die in a fire!

   • The Self Taught Man
3. 2018-09-16 at 3:26 PM UTC

   #43
   

   RisiR † 29 Autism

   Originally posted by Ensign §m£ÂgØL You wouldn't be able to participate in the discussion, no offense. We all have our own interests.

   
   You need another pegging. Your §m£ÂgØL is showing.
4. 2018-09-16 at 3:30 PM UTC

   #44
   

   Glokula's Homabla African Astronaut
   wordenhancement §m£ÂgØL to fedora
5. 2018-09-16 at 5:13 PM UTC

   #45
   

   Ensign Galm African Astronaut [specifically erupt this tetrachloromethane]

   Originally posted by Glokula's Homabla me probably the most of anyone on this site

   
   
6. 2018-09-16 at 5:41 PM UTC

   #46
   The Self Taught Man Black Hole
   Oxycodone is the only Preg Cat. B opioid.
   
   They made a really big point about that in intro to pharm.
   
   This reasoning is based on a small, shit tier study probably funded by Purdue. Logic would tell us that any opioid that passes on to breastmilk, including oxy, is going to go to the baby and affect it.
   
   It's not even that oxy has shown to be less damaging than others, it's just that a study showed that in small pain relieving doses it didn't seem to hurt babies, because most opioids in low doses aren't going to cause statistically significant damage to a baby.
   
   Oxycodone is regarded as "safer" simply because a study was performed on it, and there aren't direct studies yet on how other opioids affect pregnancies, so it wins by default.
   
   Are there better ones? Could be, but not enough money to fund research into figuring it out.
7. 2018-09-16 at 5:55 PM UTC

   #47
   

   Glokula's Homabla African Astronaut

   Originally posted by DietPiano Oxycodone is the only Preg Cat. B opioid.
   
   They made a really big point about that in intro to pharm.
   
   This reasoning is based on a small, shit tier study probably funded by Purdue. Logic would tell us that any opioid that passes on to breastmilk, including oxy, is going to go to the baby and affect it.
   
   It's not even that oxy has shown to be less damaging than others, it's just that a study showed that in small pain relieving doses it didn't seem to hurt babies, because most opioids in low doses aren't going to cause statistically significant damage to a baby.
   
   Oxycodone is regarded as "safer" simply because a study was performed on it, and there aren't direct studies yet on how other opioids affect pregnancies, so it wins by default.
   
   Are there better ones? Could be, but not enough money to fund research into figuring it out.

   
   1. sort opiates by molecular weight
   2. pick the top ten viable opiates that are the heaviest
   3. pick the one that is most bioavailable in non oral routes like transdermal
   4. opiate that is perfectly safe for pregnancy now moves on to testing (by purdue)
8. 2018-09-16 at 5:56 PM UTC

   #48
   

   Glokula's Homabla African Astronaut

   Originally posted by Ensign §m£ÂgØL

   
   you're bad at everything
9. 2018-09-16 at 5:59 PM UTC

   #49
   The Self Taught Man Black Hole
   That article is interesting.
   
   Do you think people who dedicate their lives to studying opioids are probably all junkies but somehow manage to go to work and get be productive?
10. 2018-09-16 at 6 PM UTC

    #50
    

    Glokula's Homabla African Astronaut
    no therye NERDS
11. 2018-09-18 at 10:59 AM UTC

    #51
    

    Rizzo in a box African Astronaut [the rapidly lightproof ovariectomy]
    where's my fucking money