2015-09-27 at 11:12 PM UTC
So, I've made a few posts about buspar, buspirone, the "shitty useless anti anxiety drug" and most responses are either it does nothing or it makes people feel worse.
Well, I honestly don't know how it makes me feel, probably better but because of my obsessive tendencies on drug pharmacology/knowledge of it, if it appears that something is an antagonist, etc etc than it triggers a negative placebo affect and makes me feel worse but after extensively analyzing articles on buspirone I've found some interesting stuff
Well, wikipedia says that buspar is a 5ht2 something agonist or whatever, turns out its only active on 5ht1a as an agonist like most non benzo anxiolytics. Some other sources cite that buspar is a dopamine antagonist on D2,D3 and D4 and others say its an agonist at presynaptic sites but I found an interesting article that states that it failed to increase L-dopa accumulation, which is what agonists do. But on post synaptic receptors it failed to induce catalepsy, which typically happens with dopamine antagonists like haldol, thorazine, etc. buspar combined with apomorphine in rats didn't significantly cause hypomotility different from apomorphine alone. So, that proves that its possibly antagonistic effects are very weak
So wtf?
Buspar increased tyrosine hydroxylase in the corpus striatum, so wtf again?
tl;dr - buspar is a shit drug [FONT=sans-serif]
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2015-09-27 at 11:32 PM UTC
Yeah but buspar also increases DOPAC concentrations, much like antipsychotics, so technically increase in dopamine isn't always good
2015-09-28 at 2:18 PM UTC
Buspar gave me headaches.
