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Attack doses of antipsychotics
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2015-09-01 at 12:16 AM UTC
once I was given compazine in the er for nausea, and that shit gave me akathisia that lasted like 2 days.
Every time i take anti-psychotics i get akathisia as well. I think it has something to do with opiate dependence, past or present. -
2015-09-01 at 2:40 AM UTCWhat would your opinion on the long term use of antipsychotics for cognitive enhancement alongside the treatment of schizophrenic/schizotypal symptoms?
Almost all atypicals do good things for the brain; protecting neurons from excitotoxicity, attenuating damage caused by ischemic strokes, reducing microglial activation, increases in brain-derived neurotrophic factor and nerve growth factors, antioxidant activities, reducing memory deficits induced by PCP and dopamine receptor damage from methamphetamine, etc... but at the same time they also cause brain tissue shrinkage over time, which has been associated with the course of psychotic disease but also with antipsychotic treatment itself. As well as tardive dyskinesia which could be permanent, and metabolic side effects.
Do you think being on a sizable dose of antipsychotics for an extended period of time would do more good than harm or more harm than good for someone who isn't outright hallucinating UFOs and shit?
For a while I had my nootropic regimen down pretty well: sertraline for enhanced 5ht signaling and therefore neurogenesis, mirtizapine promoting neurogenesis by indirectly affecting 5ht due to the related catchetolamine norephinephrine being affected which also might play some role, valproic acid which grows GABAergic interneurons which can help control faulty or overexcited signals, and is a powerful inducer of ERK-pathway related nerve growth, aririprazole for the positive effects of antipsychotics with a reduced chance of tardive dyskinesia and some mild euphoria due to the partial dopamine agonism, and dextroamphetamine which I think worked synergistically with the sertraline and mirtizapine (SSRI and NaSsa) for the release of additional catchetolamines, as well as dextroamphetamine's effect on dedritic sprouting.
Now I'm only on bupropion 100mg which sadly reduces BDNF levels but prevents neurogenesis reductions in mice induced by chronic restraint stress which is supposed to analogous to stress in humans, overall it has a brain-friendly effect and feels sort of like cocaine so it's worth it, 50mg of lamictal as a mood stabilizer, valproic acid would be better for the purpose of brain growth but it can also cause baldness and shit like that, but it still helps. Now I'm getting put on risperdal because I talked about how ashley deserves to die and I mentioned that I go telepathic sometimes chu no. Apparently the most effective atypical for psychosis, I'm unsure if that's due to nerve promoting effects or it's a high efficacy dopamine antagonist and that's about it. Also have a multivitamin and 6000mg of fish oil every day keep my networks WD-40'd.
Toxic psychiatric medication wishlist:
Wellbutrin + Strattera + Abilify + Buspirone + Lamictal + Low dose naloxone (look it up, think rebound effects) + Sertraline -
2015-09-01 at 3 AM UTCif you don't know about the long-term effects of antipsychotics, let me tell you, sploo, its fucked up. you will get fat and walk with a shuffle, probably have tremors or toungue-waggling....its fucked up.
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2015-09-01 at 3:16 AM UTC
if you don't know about the long-term effects of antipsychotics, let me tell you, sploo, its fucked up. you will get fat and walk with a shuffle, probably have tremors or toungue-waggling….its fucked up.
He headed in that direction either way. -
2015-09-01 at 3:31 AM UTC
What would your opinion on the long term use of antipsychotics for cognitive enhancement alongside the treatment of schizophrenic/schizotypal symptoms?
Almost all atypicals do good things for the brain; protecting neurons from excitotoxicity, attenuating damage caused by ischemic strokes, reducing microglial activation, increases in brain-derived neurotrophic factor and nerve growth factors, antioxidant activities, reducing memory deficits induced by PCP and dopamine receptor damage from methamphetamine, etc… but at the same time they also cause brain tissue shrinkage over time, which has been associated with the course of psychotic disease but also with antipsychotic treatment itself. As well as tardive dyskinesia which could be permanent, and metabolic side effects.
Let me use an analogy to convey my thoughts about these drugs. If i'm in a medical coma on anasthetics 24/7/365 i'm not going to be uncomfortable, and i probably have a reduced chance of getting in a car accident as well, not to mention i'm already in the hospital should my body crap out on me. But, does it generally improve my standard of living? No it doesn't, of course anti-psuchotics will prevent neurotoxicity, because they prevent the neurons from getting excited in the first place. Of course something could be said for it's effects in helping mediating damage caused by other drugs. But to include a regimen of anti-psychotics in your daily nootropics would not yield a net-benefit when you factor in the reason why it is helpful and the reasons why it may be destructive in the long run.Do you think being on a sizable dose of antipsychotics for an extended period of time would do more good than harm or more harm than good for someone who isn't outright hallucinating UFOs and shit
People who are psychotic or schizophrenic have an over active dopamine system so yes i think iot would be good.For a while I had my nootropic regimen down pretty well: sertraline for enhanced 5ht signaling and therefore neurogenesis, mirtizapine promoting neurogenesis by indirectly affecting 5ht due to the related catchetolamine norephinephrine being affected which also might play some role, valproic acid which grows GABAergic interneurons
Sertraline binds with the 5-HT transporter while mirtizapine binds to the receptor as an antagonist/inverse agonist in the case of 5-HT receptors taking both at the same time seems counter-productive. Since on the one hand you're pumping more 5-HT out of the transporter but you're stopping a lot of that excess 5-HT from binding due to the fact that mirtizapine has a pretty high affinity for the same receptors.
Also, i am not sure how much 5-HT is involved in neurogenesis.which can help control faulty or overexcited signals, and is a powerful inducer of ERK-pathway related nerve growth
I think you got the relation between ERK and GABA backwards. ERK regulates GABA.
http://www.ncbi.nlm.nih.gov/pubmed/17013930aririprazole for the positive effects of antipsychotics with a reduced chance of tardive dyskinesia and some mild euphoria due to the partial dopamine agonism, and dextroamphetamine which I think worked synergistically with the sertraline and mirtizapine (SSRI and NaSsa) for the release of additional catchetolamines, as well as dextroamphetamine's effect on dedritic sprouting.
That's cool, but if you're taking anti-psychotics together with catecholamines releasers/re-uptake inhibitors you're going to mess up the binding at certain sites.Now I'm only on bupropion 100mg which sadly reduces BDNF levels but prevents neurogenesis reductions in mice induced by chronic restraint stress which is supposed to analogous to stress in humans, overall it has a brain-friendly effect and feels sort of like cocaine so it's worth it, 50mg of lamictal as a mood stabilizer, valproic acid would be better for the purpose of brain growth but it can also cause baldness and shit like that, but it still helps. Now I'm getting put on risperdal because I talked about how ashley deserves to die and I mentioned that I go telepathic sometimes chu no. Apparently the most effective atypical for psychosis, I'm unsure if that's due to nerve promoting effects or it's a high efficacy dopamine antagonist and that's about it. Also have a multivitamin and 6000mg of fish oil every day keep my networks WD-40'd.
Toxic psychiatric medication wishlist:
Wellbutrin + Strattera + Abilify + Buspirone + Lamictal + Low dose naloxone (look it up, think rebound effects) + Sertraline
Nigger i know all about ULD naloxone, also lol abilify. What's more, you don't want strattera, it's all the jitters of stimulants without the actual nice dopamine feeling. -
2015-09-01 at 3:44 AM UTCSertraline was taken in the morning and mirtizapine at night, that way they don't cancel each other out. One stimulates, one sedates. I'm assuming the 12 hour period between each dose is enough time to reap the benefits of the specific chemical before they would poop out on each other.
I remember reading something about how atomoxetine enhances choline production and efficacy but I can't find the article at the moment, I'll post it when I do.
About antipsychotics messing up the binding, on the other hand the lower amount of binding on the receptors not bound by antipsychotics could lead to "more efficient neurosculpting" or something like that, because the receptors that get bound to by antipsychotics first I assume are the less critical "pores", since something must determine which sites and bound to before others when the neurotransmitter is the same. It could have a diluting or potentiating effect, can't say for sure. -
2015-09-01 at 3:46 AM UTCdoes ULD naloxone do anything worthwhile?
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2015-09-01 at 3:50 AM UTCThe main reason I was considering it was because if you take it at night, you have reduced endegenous opiod levels while you sleep, and then by the time you're awake you have more endegenous opiods in your system than you normally would because of the rebound effect. It would be a novel sort of antidepressant.
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2015-09-01 at 4:10 AM UTCI was considering looking into ULD naloxone, but I am not depressed so much as disgruntled,. don't even really know why, I am just a hair-trigger asshole.
Sometimes you remind me of myself when I was young, sploo, but there is a big difference: you were raised in a somewhat normal nuclear family, while my upbringing was....lets just say that I have read about serial killers who have had similar childhoods as mine. I never got into the mcdonald triad stuff, though, I am mostly normal, except I am pretty hypervigilant and extremely manipulative.
