NEUROLOGY QUESTION

1. 2016-03-24 at 9:56 PM UTC

   #21
   

   Sophie Pedophile Tech Support

   It's kind of funny that there's that whole Glutamate Hypothesis of Schizophrenia thing, along with the Dopamine Hypothesis of Schizophrenia. Dissociatives are the only drugs AFAIK that alter the glutamate system, while at the same time being dopamine reuptake inhibitors. Mental deterioration drugs for sure but completely worth it.

   
   AMPAR is a binding site for glutamate too, if i recall barbiturates inhibit AMPA either directly or indirectly which is why they will kill you if you take enough.
2. 2016-03-24 at 10:04 PM UTC

   #22
   The Self Taught Man Black Hole

   AMPAR is a binding site for glutamate too, if i recall barbiturates inhibit AMPA either directly or indirectly which is why they will kill you if you take enough.

   
   I think schiz is much more related to the NMDAR glutamates. Because ketamine and PCP are used to mimic the positive and negative symptoms in animal models, and increased levels of kynurenic acid, a tryptorphan metabolite, is found in schizophrenics. Kynurenic acid is believed to also act as an NMDA antagonist.
3. 2016-03-24 at 10:28 PM UTC

   #23
   

   Sophie Pedophile Tech Support

   I think schiz is much more related to the NMDAR glutamates. Because ketamine and PCP are used to mimic the positive and negative symptoms in animal models, and increased levels of kynurenic acid, a tryptorphan metabolite, is found in schizophrenics. Kynurenic acid is believed to also act as an NMDA antagonist.

   
   Kynurenic acid is actually an antagonist at all glutaminergic sites. Also, there's no difference between the glutamate binding to AMPA, NMDA or Kainate receptors to the best of my knowledge. Also, increased presence of tryptophan metabolites could indicate a number of things related to the biosynthesis of 5-HT and friends. Anyway, i'm not a neurologist doing research into schizophrenia but i find the dopamine hypothesis most compelling personally.
4. 2016-03-24 at 10:38 PM UTC

   #24
   The Self Taught Man Black Hole
   Well glutamate-based drugs don't have much of an effect on positive symptoms. I think dopamine and to a lesser extent 5HT is related to positive symptoms, while glutamate deficiency is the main cause of negative symptoms, with interneuron dysfunction related to GABA causing the disorganized symptoms. But all of these effects are probably caused by a currently unknown common pathway, maybe some sort of lesion or genetic failure causing the brain to go into toxidrome mode by the age of 20something. If barbituates cause psychosis through glutamate I wonder if that has anything to do with the withdrawal delirium/psychosis that occurs from GABAergics. Ethanol is an NMDA antagonist too, not sure if benzos can affect either directly or indirectly. Even if glutamate doesn't cause the positive symptoms, with what I said before...all the neurotransmitter systems are so closely intertwined that dopamine hyperactivity could result in glutamate deficiency, or one is a risk factor for the other, who nose.
5. 2016-03-24 at 10:46 PM UTC

   #25
   The Self Taught Man Black Hole
   You call it mental deterioration I call it EVOLUTION
6. 2016-03-25 at 12:06 AM UTC

   #26
   arthur treacher African Astronaut
   I call it exhibiting bitch-like behavior
7. 2016-03-25 at 12:22 AM UTC

   #27
   

   Sophie Pedophile Tech Support
   I call it: One man's nigger is another man's president.
8. 2016-03-25 at 12:28 AM UTC

   #28
   The Self Taught Man Black Hole
   I call it Toby.
9. 2016-03-25 at 1:21 AM UTC

   #29
   

   Sophie Pedophile Tech Support
   I call it Randy Airlines.
10. 2016-03-25 at 2:51 AM UTC

    #30
    

    infinityshock Black Hole
    did he test your prostate?
    
    with both of his hands on your shoulders...?
11. 2016-03-25 at 4:48 AM UTC

    #31
    

    kroz weak whyte, frothy cuck, and former twink

    Silly Americans breeding a generation of mongos. Can you imagine Bill Krozby's beaner father calling the school? Haha.

    
    My dad is as white bread as they come brah, green eyes blondish hair, kinda looks like chuck norris. And he wouldn't call the school he would just show up because he knows how the libtard teachers would shit themselves at a parent that has money actually showing them up.
12. 2016-03-25 at 5:40 AM UTC

    #32
    arthur treacher African Astronaut

    My dad is as white bread as they come brah, green eyes blondish hair, kinda looks like chuck norris. And he wouldn't call the school he would just show up because he knows how the libtard teachers would shit themselves at a parent that has money actually showing them up.

    
    
    
    [SIZE=14px]Bill Krozby's dad[/SIZE]:
    
    
    
    
    
    
13. 2016-03-25 at 7:39 PM UTC

    #33
    

    kroz weak whyte, frothy cuck, and former twink
    ^lol sure.... haters gonna hate.