Posts by melissageorge

1. 2017-03-08 at 9:06 AM UTC in Some information about di-sulfide bond localization analysis
   melissageorge Yung Blood
   Disulfide bond is a single covalent bond formed between the sulfur atoms of cysteines. The other sulfur-containing amino acid, methionine, cannot form disulfide bonds. Because it is a covalent bond, disulfide bond is often considered to be the primary structure. However, the function of disulfide bonds are far more than components of primary protein structure, they play a very important role in stabilizing the tertiary and quartenary structures, and are the prerequisite of proteins’ proper biological function.
   http://bit.ly/2mEuQ4Q
2. 2017-03-08 at 7:28 AM UTC in What are main protein aqua strategy?
   melissageorge Yung Blood
   Advances in biological mass spectrometry have resulted in the development of numerous strategies for the large-scale quantification of protein expression levels within cells. Besides the measurements of protein expression accomplished through differential incorporation of stable isotopes into cellular proteins, the absolute quantification is a useful method in proteomics analysis.
   http://www.creative-proteomics.com/services/absolute-quantification-aqua.htm
3. 2017-03-07 at 6:50 AM UTC in Research use information on peptide synthesis service
   melissageorge Yung Blood
   In the quantitative proteomics research, several MS-based methodologies for relative quantification have been introduced for comparison of different proteomes from collected biological samples. Meanwhile, MS-based methods for absolute quantification of specific proteins have been developed to accurately determine the protein concentrations. According to the guidelines for bioanalytical methods, the establishment and validation of accurate analytic proposals require standard compounds of high purity for calibrating and quality controls. Currently the dominant quantitative strategy is usually a combination of shotgun method and isotope dilution strategy. The targeted proteins in the complicated biological samples would release free peptide fragments induced by specific enzymatic cleavage, and the stable peptides with unique primary sequences in the digest mixture would be utilized as surrogates for corresponding parent proteins, so the small-molecular peptides can be quantified to estimate the protein concentration.
   
   Scientist’s at Creative Proteomics specialized in the custom synthesis of synthetic peptides and peptide based molecules, providing a confidential and efficient service at competitive prices.
   More: http://www.creative-proteomics.com/services/customized-synthesized-peptide-proteins.htm
4. 2017-03-07 at 4:24 AM UTC in More information about post translational modification glycosylation
   melissageorge Yung Blood
   Glycosylation, the attachment of sugar moieties to proteins, is a post-translational modification (PTM) that provides greater proteomic diversity than other PTMs. Glycosylation is critical for a wide range of biological processes, including the attachment of cell to the extracellular matrix and intracellular protein-ligand interactions. This PTM is characterized by various glycosidic linkages, including N-, O- and C-linked glycosylation, glypiation (GPI anchor attachment), and phosphoglycosylation, etc.
   More related information: http://www.creative-proteomics.com/services/glycosylation-analysis-of-protein.htm
5. 2017-02-13 at 4:13 AM UTC in More information about glycosylation analysis of protein
   melissageorge Yung Blood
   Glycosylation, the attachment of sugar moieties to proteins, is a post-translational modification (PTM) that provides greater proteomic diversity than other PTMs. Glycosylation is critical for a wide range of biological processes, including the attachment of cell to the extracellular matrix and intracellular protein-ligand interactions.
   
   More detailed information: http://www.creative-proteomics.com/services/glycosylation-analysis-of-protein.htm