Guanfacine

1. 2024-07-08 at 11:50 AM UTC

   #1
   

   xy0 Houston
   Not much to note until about 3mg per day. then wow, constant starburst effect, immense tiredness, trembling muscles, shallow breaths, constantly feel 5 seconds away from passing out. dry mouth, headach,
   
   but yet for some reason i think it kinda helps me get things done, in a paradoxical way i guess.
   
   how do i make the most of this shit drug?
2. 2024-07-26 at 4 AM UTC

   #2
   

   Kingoftoes Houston
   Don't take it.
   
   Never met anyone that has had a good experience using Guanfacine, including myself. Just made my brain foggy and made me VERY sleepy.
3. 2024-07-26 at 4:03 AM UTC

   #3
   

   Bradley Florida Man [my infernally top-secret etiology]
   It's a high blood pressure pill, the fuck you thinking it's gonna be like
   
   good?
4. 2024-07-26 at 9:22 AM UTC

   #4
   

   the man who put it in my hood Black Hole [miraculously counterclaim my golf]
   butt jedis
5. 2024-07-26 at 10:41 AM UTC

   #5
   

   the man who put it in my hood Black Hole [miraculously counterclaim my golf]
   (guanfacin$ or Afken or Estulic
   Chemical Name: N-amidino-2-(2,6dichlorophenyl) acetamide monohydrochloride
   
   (CAS NO.: ), with its systematic name of acetamide, N-(aminoiminomethyl)-2,6-dichloro-, monohydrochloride, could be produced through many synthetic methods.
   
   Following are some of the synthesis routes:
   
   Method one:
   1). By methanolysis of 2,6-dichlorophenylacetonitrile (I) in the presence of H2SO4 to methyl 2,6-dichlorophenylacetate (II), which is then condensed with guanidine (A) in isopropanol.
   2). By condensation of S-methylisothiourea (V) with 2,6-dichlorophenylacetyl chloride (VI) in acetone to afford S-methyl-N-(2,6-dichlorophenylacetyl)isothiourea (VII); this product is then treated with ammonia in isopropanol.
   3). By condensation of 2,6-dichlorophenylacetic acid (VIII) with guanidine (A) in toluene.
   
   EXAMPLE 4 2,6-dichlorophenyl-acetyl-guanidine hydrochloride A solution of 65.7 g. (0.3 moles) of 2,6-dichlorophenylacetic acid methyl ester (B.P. 149 C./ 17 mm. of Hg) in 200 cc. of isopropanol is added to a solution of 19.5 g. (0.33 moles) of guanidine in 150 cc. of isopropanol. The resulting reaction mixture is stirred for 15 minutes and is then concentrated by evaporation in a vacuum. The resulting white residue, consisting of 2,6-dichlorophenylacetyl-guanidine, is suspended in 100 cc. of isopropanol, whereupon acidification is effected with ethanolic hydrochloric acid. The resulting precipitate is crystallized from isopropanol/ethanol and recrystallized from ethanol. 2,6 dichlorophenyl acetyl guanidine hydrochloride is obtained in the form of white needles having a melting point of 215-217 C.
   
   
   making the 2,6-dichlorophenylacetic acid methyl ester would be easy I think.
   will add an OTC route to this in my book