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Male buttsex associated with immune disregulation

  1. #1
    Donald Trump African Astronaut
    Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males
    S Kuno, R Ueno, O Hayaishi
    PMID: 3458226 PMCID: PMC323363 DOI: 10.1073/pnas.83.8.2682
    Free PMC article
    Abstract
    To explain a possible pathogenesis of acquired immune deficiency syndrome (AIDS) in homosexual males, we propose the following hypothesis. Prostaglandin E2 in human semen given via anus during anal intercourse may cause an immune dysregulation in the male semen recipients; this immunosuppressive effect of prostaglandin E2 may be one of the underlying factors that stimulate AIDS-associated virus infection or that trigger the latent AIDS-associated virus. This hypothesis is supported by the following experimental results. Anal infusion of prostaglandin E2 or D2 into male rats reduced in vitro responses of T lymphocytes to phytohemagglutinin. However, the T-cell response of female rats was not reduced significantly by the anal infusion of seminal prostaglandins.

    https://pubmed.ncbi.nlm.nih.gov/3458226/


    Haha what the fuck?
  2. #2
    Meikai African Astronaut
    So, just like... no bareback and you can't get AIDS? So nothing has changed really?
  3. #3
    Donald Trump African Astronaut
    Originally posted by Meikai So, just like… no bareback and you can't get AIDS? So nothing has changed really?

    I don't think they're talking about AIDS, so much as general lowered immunity. Semen is full of hormones which, for instance, turn off the immune response in recipients so that the immune system doesn't kill sperm. It seems like biological females have some sort of resistance to the effect of semen. I don't know how pronounced the effect might be.

    "it is concluded that recipients of sperm constituents through the intrarectal route are at greater risk for immune suppression and bacterial/viral infection."
    https://pubmed.ncbi.nlm.nih.gov/8817472/
  4. #4
    Meikai African Astronaut
    Originally posted by Donald Trump I don't think they're talking about AIDS

    It's literally in the title of the paper.
  5. #5
    Meikai African Astronaut
    They're talking about "acquired immune deficiency syndrome (AIDS) in homosexual males" but you don't think they're talking about acquired immune deficiency syndrome (AIDS), a disease widely known for its disproportionate impact on homosexual males?

  6. #6
    Meikai African Astronaut
    If I'm reading the abstract correctly it sounds like the hypothesis is that immunosuppression caused by rectal administration of Prostaglandin E2 in semen may open the door for a latent HIV infection to trigger full-blown AIDS (and/or it opens the door for the initial HIV infection).

    Of course this wouldn't really explain female AIDS patients and heterosexual AIDS patients, so it's not a broadly applicable pathogenesis, but it's an interesting hypothesis I guess.
  7. #7
    POLECAT POLECAT is a motherfucking ferret [my presentably immunised ammonification]
    Originally posted by Donald Trump I don't think they're talking about AIDS, so much as general lowered immunity. Semen is full of hormones which, for instance, turn off the immune response in recipients so that the immune system doesn't kill sperm. It seems like biological females have some sort of resistance to the effect of semen. I don't know how pronounced the effect might be.

    "it is concluded that recipients of sperm constituents through the intrarectal route are at greater risk for immune suppression and bacterial/viral infection."
    https://pubmed.ncbi.nlm.nih.gov/8817472/

    you been doin a lot of research on the subject,, planning a life change?
  8. #8
    Donald Trump African Astronaut
    Originally posted by Meikai If I'm reading the abstract correctly it sounds like the hypothesis is that immunosuppression caused by rectal administration of Prostaglandin E2 in semen may open the door for a latent HIV infection to trigger full-blown AIDS (and/or it opens the door for the initial HIV infection).

    Of course this wouldn't really explain female AIDS patients and heterosexual AIDS patients, so it's not a broadly applicable pathogenesis, but it's an interesting hypothesis I guess.

    Even leaving AIDS out I think it's interesting.

    Semen has already been shown to act as an anti-depressant in females.
    https://www.newscientist.com/article/dn2457-semen-acts-as-an-anti-depressant/
  9. #9
    Donald Trump African Astronaut
    Originally posted by POLECAT you been doin a lot of research on the subject,, planning a life change?

    Why, you looking to do some hand-on research?
  10. #10
    POLECAT POLECAT is a motherfucking ferret [my presentably immunised ammonification]
    NO.
  11. #11
    Ghost Black Hole
    and people DRINK that stuff
  12. #12
    Bradley African Astronaut
    This is a common issuefor all men who are being anally pounded. My mom said Collitis is from getting fucked in the ass and would make fun of this man she knew (he wasn't gay) and tell people he got it from being fucked in the ass. Now is this the same woman who believed I knew a magic "hand sign" that i could flash at other men and if they wanted to be anally pounded they would flash it back twice.

    So i'm not sure if she's the best source of information for immunosuppressant reaction from getting anally gaped from some nice man.

    I heard the smaller the dick the less likely you are to experience any sort of tearing or affect.

    Wouldn't know.
  13. #13
    Ghost Black Hole
    Originally posted by Bradley Now is this the same woman who believed I knew a magic "hand sign" that i could flash at other men and if they wanted to be anally pounded they would flash it back twice.

    You clearly aren't down with the cruising culture then because out back behind the YMCA all I gotta do is wear my daisy dukes and oil up my muscles and anchor tattoo and make my snake dance (the tattoo, not my dick) and wave my hands to the passing cars and i'll have a date in no time

  14. #14
    Bradley African Astronaut
    Originally posted by Ghost You clearly aren't down with the cruising culture then because out back behind the YMCA all I gotta do is wear my daisy dukes and oil up my muscles and anchor tattoo and make my snake dance (the tattoo, not my dick) and wave my hands to the passing cars and i'll have a date in no time


    do they have grindr in canada? What you just described is grindr but in an app.

    people have explained to me the cruising culture but because I don't drive and am apprehensive about strangers (I've met less than 6 men from grindr and had it for like two years) i don't know :P Never got int oit.
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