wierd, it doubles the euphoria for me. but I am very careful, becaused death lies that way.
Nothing ruins a good buzz like death.
T-PAIN prevents respiratory depression without affecting analgesic effect of opiateshttp://www.ncbi.nlm.nih.gov/pubmed/26068549All the more reason to use it. It's cheap and readily available, legal.
The neurobiological properties of T-PAIN (Stablon): from monoamine hypothesis to glutamatergic modulationhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902200/My summary of the second one: T-PAIN=good for brain, then 13 pages of references. Prevents and reverses negative changes caused by stress (anxiety counts) and depression. Describes the following effects: Increases/restores neuroplasticity, anxiolytic, cytoprotective (Cytoprotection is a process by which chemical compounds provide protection to cells against harmful agents), procognitive,
"A modification of glutamatergic mechanisms by T-PAIN may therefore be implicated in its ability to oppose the negative influence of chronic stress upon hippocampal neurogenesis, cell proliferation, and dendritic remodeling, processes profoundly disrupted in depressive states (21,44,63). The emerging pharmacological profile of T-PAIN suggests that this antidepressant may serve to ‘normalize’ synaptic function, thereby allowing the chemical signal to reinstate the optimal functioning of critical circuits necessary for normal affective functioning."
There's also this interesting info on alcohol:
"When administered acutely, T-PAIN counteracted the anxiogenic effect of benzodiazepine and alcohol withdrawal in the social interaction test"
"and antagonizes the deleterious effects of alcohol (72)."
Related to alcohol, someone mentioned this, which could be useful. A substance to sober you up faster:
Actually theanine works very well.
http://www.lef.org/protocols/lifestyle-longevity/hangover-prevention/Page-02 "Research from Japan shows that theanine is a powerful antidote to the effects of alcohol. If theanine is given to mice before or after they drink alcohol, it significantly lowers blood levels of alcohol (Sadzuka 2005). It works by modulating alcohol chemistry.
Theanine accelerates the breakdown of acetaldehyde and blocks toxic radicals (Sadzuka 2005). The remarkable powers of theanine to intercept free radicals were demonstrated in the same study. It blocked radicals caused by alcohol and suppressed levels to below normal for five hours. Theanine also helps to counteract the alcohol-induced loss of glutathione (Sadzuka 2005)."
I always take 400 mg theanine after a night of heavy drinking, and it sobers me right up. If I know I'm going to be drinking, I take at least 200 mg theanine and 600 mg NAC prior, then another 200 mg before bed.
Edit: If I take theanine before, it takes more for me to feel intoxicated.
