2018-10-10 at 11:03 AM UTC
would this work? why salt PSE from NP just to turn around and send the PSE freebase again in a reduction.
The only reason to salt would be to weigh it before the run.
Does the PSE need to salted out after the cleaning process or could it be keep it in the NP then combine with the reactants.
2018-10-10 at 2:38 PM UTC
You have no hydrogen source in your reaction scheme.
You have to use either the HCl salt of pseudoephedrine or an alcohol (anhydrous, so take IPA or methylalcohol, dry!)
But using the HCl salt is better and easier.
A hydrogen source is needed, In the RP/I the HI provides it, in the Birch the HCl of pseudo.HCl or an alcohol when the freebase used. I cant remember to have heard that toluene can be used instead.
Use the HCl salt. Toss it in all at once when you have the blue. Stirring is usually a good idea, but on the small scale you are working a gently swirling of the flask will suffice (DONT SHAKE!), dont forget the gloves though.
2018-10-10 at 5:21 PM UTC
Thanks, I had no idea about needing a hydrogen source.
2018-10-10 at 7:17 PM UTC
Isopropyl alcohol is a good hydrogen donor
2018-10-11 at 1:19 AM UTC
I'll do more research or if anyone has any tips, pm me
