General rules of alternative Clendestine Chemistry, a "New Old" or "Russian" approach which can use
less concetrated,less pure substrated and rather 2-3x more steps of most basick quantitative and
well-known high-yielding methods rather than than maximum of 3-4 "more fancy" based on same
general template of couple of highly pecific Additions->some kind of Reduction->further complex,expensive and highly specific reaction (most ofthen some reduction or addition) utilizing non.verestaile dangerous substrates and Catalysts of very narrow use->one more specialized reaction like Reduction in general to trim down or
or add a final touch to molecule!
Instead,"New Old" approach follows chains of these these basic rules and their derivatives using only what we can got now or immediate future untill we got what we need:
of Acids,Bases,Alcohols,Ethers and Aryl/Ally/Alkyl Halogenes performing most simple reactions of foundamental of numerous possible additions,substitutions/eleminations of (Hydro)Halogenations,1°Amination and Alkylations with only OTC catalysts and co-reagents like MetalHalogenes,MetalOxide,(Alkaly)Metals INORGANIC Bases,their Halogen Salts,
Mineral Acids,Anhydrides,Halogens and Hydrohalog acids! WITHOUT ANY USE of improbable and impossible to find or pay rare/noble Element,their compounds adducts and hazardouse shit like liquid Ammonia,Amides and ustable/complex Nitrogen species (like amide,Hydrides,Organo-Metallic bases and salts and) and Aliphatic Carbons using more than 3 Carbons and more than 2 unsubstituted C+C bounds or more than one Oxigen species,resulting in umerous similar and complex reaction mechaninism that use tricky,dangerous and non-OTC catalysts(like Ketones,Aldehydes,Esters,Furanes,(Di)oxanes,Oxides,Oximes,Nitrates,Nitriles...)
Well,sounds pretty darn restricting,but whole point of this is to do more symilar but usualy opposite reactions,utilizing impossible to ban or restrict reactants and knowledges and building blocks:
(Any such regulation would do MUCH more dammage to economy in general than clndestine chemistry!)
For Example,traditional OTC reaction of preparing Methadone calls for use of simple NaOH/KOH instead of numerous crappy orgainc bases but at the same time requires Halogen-Propan-Amine that stop any such attempt dead in it's tracks using not that friendly nor smart to use cousings of mustard gas,and reactively non-selective Aziridinium Kation.
But here is MUCH more OTC method that uses only OTC reagents and OTC procedures::
1.)Instead of 2-chloro-1-dimethylpropane and it's structural isomeres forming Aziridine,where instead one can simple make:
Allyl Alcohol aka Prope-2-en-1-ol (H2C=CH-CH2-OH) using destructive distillation of Glcerine and Formic Acid (with some Fe2O3)
http://www.orgsyn.org/demo.aspx?prep=cv1p0042Alkyl Halogen can be prepared by the same method non-purified product of above synthesis of AllylAlcohol using ecactly the same reaction one would use to make CloroEthane<BromoEthane<IodoEthane from coresponding Etanol, HX acid and acidic catalyst!
More stable R-Halogen species can be easily stored and in the end tranformed into best leaving group halogen trough Finkelstein Reaction (froming AllylIodide). There are numerous documented (and probably MUCH MUCH more undecomented combinations of solvent and Catalyst procedures to make probably near quantitative ammounts of desirable 2,2-Diphenyl-1-Prope-2-en Acetonitrile by reaction that claims the following:
Ph
I
CN-C-H + Cl-CH2-HC=CH2 --->(Solvated by "X",catalyzed by "Bases" and "X" further information on...
I
Ph Ph
I
...eiter reaction conditions,reaction intermediate,mechanism,yields or similar)---> CN-C-CH2-HC=CH2
I
Ph
+ NaBr + H2O + Proton probably a leftower from intermediate that is neutralized in the extraction)
FOR ALL USABLE REFERENCES OPEN HYPERLINKS [16,17,18 AND 19] OR for other bunch or usable lcendestine reactions pen from [11] to [22]
OF THE LINK :
https://en.wikipedia.org/wiki/Sodium_amideBased on available evidence and (relatively scarce literature at the moment) I couldn't find any documented BETTER solvent/catalyst/Method other than combination of AllylBromide(maybe better leaving Iodide group with milder base or Chloride with strongest organic bases!) than damn anhyd. liquid NH3 as solvent reacting with Na and catlytic FerricNitrate to form in situ NaNH2 catalyst and further solvent addition/substitution by Et2O with some reflux and H2O followed by non-polar extraction and distillation!. I assume that some kind of more OTC method using either LiOH as simple innorganic Base or easy to make M-Alkoxide as catalyst and Polar Aprotic solvent like DMF/DMSO/CH3-CN can be used in this case but if available THF with some other "more appropriate/specialized" catalyst or Aromatic/Water bi-layer using heat,aezotrope formation and non solubility of by-products aided by combo of strong MOH Base
and Phase-Transfer-Catalyst "Quad" one can order on-line,might be border-linea-cceptable procedure at elevated temperature!
But in short,I HAVE NO IDEA about pecific reaction other than assuming general Sn2 following the same mechanism that IodoMethane or BromoEthane alkylation use,where terminal unsaturated and untouched C=C bound doesn't interact here at all. I was sure this is not possible using Aziridinium Kation intermediate but more I learned,less certain I am what exact mechanism actually is.
IF ANYONE KNOWS WHAT SOLVENT OTHER THAN PESKY NH3(L) AND OTHER CATALYST THAT ISNT AMIDE LIKE NaNH2 OR SIMILAR USTABLE CRAP IS UDESIRABLE!!!
DESIRABLE CATALYST IS EITHER READY TO USE LiOH/NaOH/KOH OR IN SITU FORMATION OF (Earth)AlkalyMetals+ R-OH-(aka. Alkoxides)
I othervise completely ignorant when it comes to use and iterchagebility of compley array of more compley bases like Organo-Alkyls,AlkalyMetal-Nitrogen and TetraOrganoAmmonium Halides!!!
ANY KIND OF HELP IS NEEDED!
NEXT STEP using Merkonikov HydroHalogenation to get spproprate b-Methyl isomere and further formation of amine using allmost same reaction as this one is following! Synthesis of substituted-Amphetamines(s) can also be done from the same reactions and their modifications!
Untill opening this chapthert,any further refferences and ideas how to do THIS REACTION IN PARTICULAR USING simpler Catalysts and better yielding METHODS is DESIRED GOAL,solvent being secondar as long as non-extremely toxic and more termally stable than NH3(L)!!!
