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gabapentin makes me hallucinate
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2017-01-17 at 8:13 PM UTC2g+ and i'm getting 3D patterns
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2017-01-17 at 8:17 PM UTCIsn't gabapentin also a sodium channel blocker?
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2017-01-17 at 8:19 PM UTCNaChan is best chan
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2017-01-17 at 8:27 PM UTC
Originally posted by Sophie Isn't gabapentin also a sodium channel blocker?
It isn't a GABA agonist but increases GABA synthesis by altering some brain enzymes, and increases response from non synaptic GABA cells (whatever that means), so calling it a GABAergic is probably technically wrong. It also alters an enzyme responsible for glutamate synthesis.
Sodium channel blocker on one particular subunit which makes it belong to the class "gabapentinoid"
Also decreases all monoamine release probably due to those mechanisms but I think I read once it increases serotonin levels over time.
I actually wonder what mechanism causes gabapentin to get someone high the first time they try it. It usually never works the second day even. Especially why I'm getting visuals. Maybe the glutamate level alteration makes it like an NMDA antagonist.
https://www.ncbi.nlm.nih.gov/pubmed/9686247
Interesting drug
Post last edited by the holy ghost at 2017-01-17T20:31:34.458601+00:00 -
2017-01-17 at 10:18 PM UTCI took gabapentin for the first time yesterday. I felt like i was high on marijuana and drunk ..atleast in the way i was thinking its weird stuff. I liked it though didn't halucinate but i was tripping out having deep thoughts about my life...it was kind of scary
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2017-01-17 at 10:35 PM UTCIsn't it a good drug? How much did you take?
Having a prescription 600mg a day is pretty dank, but I convinced my dad to let me take 900mg a day for 20 days and then none for 10 days for tolerance break
I need 2000-3000mg to get decently high, also I can feel it the next day. It has an intense rush for about a minute, then resembles a benzo crossed with a dissociative for 4-24 hours.
You can't take it all at once because it's bioavailability decreases when you take more. You have to take 300mg every 15-90 minutes, with a fatty food and a carbonated drink because both also increase bioavailability. Naproxen apparently increases bioavailability by 15% but I never tried doing that. Getting a decent high of gabapentin is kind of a ritual because there are so many different factors that go into it, but I enjoy doing it. Feels ceremonial.
If you get high on 3g, you'll need 6g to feel the same way the next day. Tolerance goes up immediately but also resets within 3-5 days. -
2017-01-17 at 10:36 PM UTC
Originally posted by the holy ghost It isn't a GABA agonist but increases GABA synthesis by altering some brain enzymes, and increases response from non synaptic GABA cells (whatever that means), so calling it a GABAergic is probably technically wrong. It also alters an enzyme responsible for glutamate synthesis.
Sodium channel blocker on one particular subunit which makes it belong to the class "gabapentinoid"
Also decreases all monoamine release probably due to those mechanisms but I think I read once it increases serotonin levels over time.
I actually wonder what mechanism causes gabapentin to get someone high the first time they try it. It usually never works the second day even. Especially why I'm getting visuals. Maybe the glutamate level alteration makes it like an NMDA antagonist.
https://www.ncbi.nlm.nih.gov/pubmed/9686247
Interesting drug
Post last edited by the holy ghost at 2017-01-17T20:31:34.458601+00:00
I don't call it GABAergic, i called it a GABAmimetic the other day. But yeah, without going over the entire pubmed article, does it say anything about which receptor/subunit it acts as sodium channel blocker? Also, gabapentin is an interesting drug but purely from a pharmacokinetic standpoint imo, i don't particularly enjoy it's effects. -
2017-01-17 at 10:37 PM UTC
Originally posted by Sophie I don't call it GABAergic, i called it a GABAmimetic the other day. But yeah, without going over the entire pubmed article, does it say anything about which receptor/subunit it acts as sodium channel blocker? Also, gabapentin is an interesting drug but purely from a pharmacokinetic standpoint imo, i don't particularly enjoy it's effects.
https://en.wikipedia.org/wiki/Voltage-dependent_calcium_channel#.CE.B12.CE.B4_Subunit
This site is also referred to as the "gabapentin receptor" -
2017-01-18 at 1:28 AM UTCI got some cev's the first time I took it (300mg every 90 minutes for a whole night) but never again after that
Its a wonderful med to keep around for potentiation -
2017-01-18 at 1:49 AM UTCPhenibut beats all other GABA drugs and I can proof it. Come at me.
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2017-01-18 at 4:03 AM UTC
Originally posted by RisiR Phenibut beats all other GABA drugs and I can proof it. Come at me.
Except for ghb -
2017-01-18 at 4:29 AM UTC
Originally posted by RisiR Phenibut beats all other GABA drugs and I can proof it. Come at me.
phenibut is pretty fucking good. especially when you get like 200 fucking grams for 15 dollars.
dude i take like 15 grams of pheni and drank a six pack once, the world was SPINNING. i could not get to the bathroom to piss. i was just flailing all over the place. fuck spinning, the room was GYRATING in RANDOMIZED VECTORS. i was so fucking spun, i couldn't lay in bed with tripping and falling. i was so fucking rotated that when i tried to lie down i would up completely helpless at a 45 degree angle six inches hovering over the god damned bed.The following users say it would be alright if the author of this post didn't die in a fire! -
2017-01-18 at 4:56 AM UTCphenibut is shit
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2017-01-18 at 4:59 AM UTCYour drugs are shit. My drugs are the best drugs. If you disagree it's because you're a stupid idiot. Me me me me me me me me me memememememememememememememenene e e e.e.e.emememememememememrmThe following users say it would be alright if the author of this post didn't die in a fire!
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2017-01-18 at 5:18 AM UTCI love gaba but it doesn't make me see shit nemore, damn well used to big time though. I would see all kinds of weird shit, demonic stuff like devils and screaming trees, just weird mutant stuff
Post last edited by Bill Krozby at 2017-01-18T05:36:22.691429+00:00 -
2017-01-18 at 5:31 AM UTC
Originally posted by the holy ghost phenibut is shit
you might as well say that alcohol is shit, dumbass. it doesn't have different effects on everyone. it's just space vodka. -
2017-01-18 at 5:31 AM UTC
Originally posted by snab_snib it doesn't have different effects on everyone.
lol
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2017-01-18 at 5:36 AM UTC
Originally posted by the holy ghost lol
shut up you retarded, suicidal, teenage drug addict loser. you don't get to post 'lol' at me you little shit. -
2017-01-18 at 5:38 AM UTC
Originally posted by snab_snib you might as well say that alcohol is shit, dumbass. it doesn't have different effects on everyone. it's just space vodka.
I love alcohol and I love gabapentin but to me phenibut is one of the shittiest drugs I've ever done, the only redeeming factor of ordering any was they gave me a free sample of Crouton. other than that It only worked well for me the first time I ever took it and it wasn't even that great. -
2017-01-18 at 5:38 AM UTC
Originally posted by snab_snib shut up you retarded, suicidal, teenage drug addict loser. you don't get to post 'lol' at me you little shit.
lol
