Project MKUltra, also called the CIA mind control program, is the code name given to a program of experiments on human subjects that were designed and undertaken by the United States Central Intelligence Agency and which were illegal. Experiments on humans were intended to identify and develop drugs and procedures to be used in interrogations in order to weaken the individual and force confessions through mind control. The project was organized through the Office of Scientific Intelligence of the CIA and coordinated with the U.S. Army Biological Warfare Laboratories. Code names for drugs-related experiments were Project Bluebird and Project Artichoke. MKUltra used numerous methods to manipulate people's mental states and alter brain functions, including the surreptitious administration of drugs (especially LSD) and other chemicals, hypnosis, sensory deprivation, isolation, verbal and sexual abuse, and other forms of torture. The scope of Project MKUltra was broad with research undertaken at 80 institutions, including colleges and universities, hospitals, prisons, and pharmaceutical companies. The CIA operated through these institutions using front organizations, although sometimes top officials at these institutions were aware of the CIA's involvement. Most MKUltra records were destroyed in 1973 by order of CIA director Richard Helms, so it has been difficult for investigators to gain a complete understanding of the more than 150 funded research subprojects sponsored by MKUltra and related CIA programs.
One 1955 MKUltra document gives an indication of the size and range of the effort. It refers to the study of an assortment of mind-altering substances described as follows:
Substances which will promote illogical thinking and impulsiveness to the point where the recipient would be discredited in public.
Substances which increase the efficiency of mentation and perception.
Materials which will cause the victim to age faster/slower in maturity.
Materials which will promote the intoxicating effect of alcohol.
Materials which will produce the signs and symptoms of recognized diseases in a reversible way so they may be used for malingering, etc.
Materials which will cause temporary/permanent brain damage and loss of memory.
Substances which will enhance the ability of individuals to withstand privation, torture, and coercion during interrogation and so-called "brain-washing".
Materials and physical methods which will produce amnesia for events preceding and during their use.
Physical methods of producing shock and confusion over extended periods of time and capable of surreptitious use.
Substances which produce physical disablement such as paralysis of the legs, acute anemia, etc.
Substances which will produce a chemical that can cause blisters.
Substances which alter personality structure in such a way the tendency of the recipient to become dependent upon another person is enhanced.
A material which will cause mental confusion of such a type the individual under its influence will find it difficult to maintain a fabrication under questioning.
Substances which will lower the ambition and general working efficiency of men when administered in undetectable amounts.
Substances which promote weakness or distortion of the eyesight or hearing faculties, preferably without permanent effects.
A knockout pill which can be surreptitiously administered in drinks, food, cigarettes, as an aerosol, etc., which will be safe to use, provide a maximum of amnesia, and be suitable for use by agent types on an ad hoc basis.
A material which can be surreptitiously administered by the above routes and which in very small amounts will make it impossible for a person to perform physical activity.
Once Project MKUltra got underway in April 1953, experiments included administering LSD to mental patients, prisoners, drug addicts, and sex workers—"people who could not fight back," as one agency officer put it. In one case, they administered LSD to a mental patient in Kentucky for 174 days. They also administered LSD to CIA employees, military personnel, doctors, other government agents, and members of the general public to study their reactions. LSD and other drugs were often administered without the subject's knowledge or informed consent, a violation of the Nuremberg Code the U.S. had agreed to follow after World War II.
In Operation Midnight Climax, the CIA set up several brothels within agency safehouses in San Francisco, California, to obtain a selection of men who would be too embarrassed to talk about the events. The men were dosed with LSD, the brothels were equipped with one-way mirrors, and the sessions were filmed for later viewing and study. In other experiments where people were given LSD without their knowledge, they were interrogated under bright lights with doctors in the background taking notes. They told subjects they would extend their "trips" if they refused to reveal their secrets. The people under this interrogation were CIA employees, U.S. military personnel, and agents suspected of working for the other side in the Cold War. Long-term debilitation and several deaths resulted from this. Heroin addicts were bribed into taking LSD with offers of more heroin. LSD was slipped into deputy U.S. marshal Wayne Ritchie's drink of bourbon and soda. He had a bad LSD trip that culminated in his holding up the bar at gunpoint. Ritchie was fired and only decades later, in 1999, learned he had been the subject of secret drug testing. He was one of many test subjects.
The Office of Security used LSD in interrogations, but Dr. Sidney Gottlieb, the chemist who directed MKUltra, had other ideas: he thought it could be used in covert operations. Since its effects were temporary, he believed one could give it to high-ranking officials and in this way affect the course of important meetings, speeches, etc. Since he realized there was a difference in testing the drug in a laboratory and using it in clandestine operations, he initiated a series of experiments where LSD was given to people in "normal" settings without warning. At first, everyone in Technical Services tried it; a typical experiment involved two people in a room where they observed each other for hours and took notes. As the experimentation progressed, a point arrived where outsiders were drugged with no explanation whatsoever and surprise acid trips became something of an occupational hazard among CIA operatives. Adverse reactions often occurred, such as an operative who received the drug in his morning coffee, became psychotic and ran across Washington, seeing a monster in every car passing him. The experiments continued even after Dr. Frank Olson, an army chemist who had not taken LSD before, went into deep depression after a surprise trip and later fell from a thirteenth story window.
https://en.wikipedia.org/wiki/Project_MKUltra