2016-02-29 at 2:51 AM UTC
I made this while afking abyssal demons with a nox staff, sub robes, and blood barrage in runescape with a vecna boost and making approx. 1million exp per hour
2016-02-29 at 2:53 AM UTC
aldra
JIDF Controlled Opposition
lol@ all those hack attempts at the top of the user list
2016-02-29 at 2:55 AM UTC
aldra
JIDF Controlled Opposition
I'm user #3
1. lanny
2. liquidice
3. aldra
4. inb4lock
5. ccc
2016-02-29 at 3:13 AM UTC
aldra
JIDF Controlled Opposition
didn't realise it was bundyocloxx
enjoy
2016-02-29 at 3:20 AM UTC
Robitussin is basically an MMORPG in a bottle, I've never realized this before.
2016-03-01 at 12:42 AM UTC
We previously demonstrated that dextromethorphan (DM; 3-methoxy-17-methylmorphinan) analogs have neuroprotective effects, and a recent report showed that DM reduces the adverse effects of morphine and blocks a3b4 nicotinic acetylcholine receptors, a major target of anti-addictive agents. Here, we investigated the effects of DM, three of its analogs (DF, 3-methyl-17-methylmorphinan; AM, 3-allyloxy-17-methoxymorphian; and CM, 3-cyclopropyl-17-methoxymorphinan) and one of its metabolites (HM; 3-methoxymorphinan), on neuronal a3b4 nicotinic acetylcholine receptor channel activity expressed in Xenopus laevis oocytes, using the two-microelectrode voltage clamp technique. We found that intraoocyte injection of neuronal a3 and b4 nicotinic acetylcholine receptor subunit cRNAs elicited an inward current (I ACh) in the presence of acetylcholine. Co-treatment with DM, DF, AM, CM or HM inhibited I ACh in a dose-dependent, voltage-independent and reversible manner. The IC50 values for DM, DF, AM, CM and HM were 19.5 ± 5.2, 15.8 ± 4.5, 16.3 ± 1.7, 10.1±2.8, and 13.5 ± 4.0 mM, resp. The order of potency for the inhibition of IACh was CM > HM > DF = AM > DM in oocytes expressing a3b4 nicotinic acetylcholine receptors. The inhibitions of (I ACh) by DM, DF and HM, AM and CM were non-competitive. These results indicate that AM, CM and HM could be novel non-competitive agents regulating a3b4 nicotinic acetylcholine receptor channel activity.
2016-03-01 at 12:49 AM UTC
Table 4: 3-Substituted bundy Analogs 3-Position Substitution IC50 [3H]bundy IC50 [3H]TCP ED50 Rats % Rats OCH3 (bundy) 0.59M (0.12) 2.0M (0.6) 38mg/kg 70 OH (dextrorphan) 7.7M (0.9) 1.2M (0.7) 5mg/kg 90 NH2 45% at 10M 7.8M (1.4) 25mg/kg 100 NHCH3 3.6M (1.4) 43% at 10M 0 N(CH3)2 4.4M (0.9) 45% at 10M 40mg/kg 40 Cl 1.1M (0.4) 5.5M (1.5) 10 NCS 1.5M (0.3) 60% at 10M 0 H (i.e., nothing) 1.3M (0.3) 53% at 10M 0 O-Et (ethyl) 0.42M (0.06) 75% at 10M 5.6mg/kg 90 O-2-Pr (2-propyl) 0.88M (0.18) 59% at 10M 3.9mg/kg 90 O-n-Bu (n-butyl) 1.5M (0.4) 58% at 10M 40 O-Bz (benzyl) 3.1M (0.6) 39% at 10M 30
2016-03-01 at 12:55 AM UTC
The key to super bundy is through DXO. I'm thinking there must be a way to make it so you consume ONE pill and in your liver it becomes a 2 or 3 gram dose of DXO.
[FONT=verdana]Another class of sigma ligand that shows some odd dissociative effects is N-allyl-normetazocine and pentazocine (Talwin?). These compounds are also partial mu agoninsts and are (were) used as narcotics with supposed low abuse profiles for opiate fans. But in higher dosage ranges they can cause bizarre hallucinogenic effects. [/FONT]
