2017-04-22 at 5:16 PM UTC
Here is an idea to turn Naltroxon into Oxymorphon or related mass available FULL-AGONIST product,no 20x stronger than morphine.
1.) Naltrexon is a dirt cheap and available "en masse" in most places,especialy generic one. And some people are forced by authority figures to take them,no matter how bad reaction they will sufer! This is extremely barbaric!
2.)To show those LE idiots and people who force opiophiles to take naltrexon against their will and ABOVE ALL prove to the tootless meth tweakers that we are SMARTER THAN THEM,under that,I mean that such reaction should be VERY simple and afordable,alla "shake-n-bake" meth reaction compared to another reduction methods that only intelligent and skilled people could do for more than century creating inferior product! OUR REACTION/ultimate GOL should be 1-3 step reaction with chemicals that are easy to get and cheap or at least reusable infinitely!
3.)Un-doo the mass scale blasphemy where good old oxymorphone,opiate of choice for all opiate lovers,is blasphemously desecrated by
adding that God-awful phuny and unstable methylcyclopropane group on the worst place possible using simplest reaction,creating one of the best chemicals imaginable into torture device for many! I mean,really,can't we,people who can make and alter most complicated INVISSIBLE structures out there remove one lously simple reactive "tail" that spoils tons and tons of best natural opiate there is!?
Forget computer symulations of molecules,go old school!
There must be some kind of combined oxigen-hidrogenr/double -OH group bringer that would broke the damn N-methycyclopropan into AT LEAST charged/unsaturated secondary (_N(+)_) ion and etildiol(HOCH2CH2OH),more acceptable Noroxymorphone(_NH_) as john suggested with some chlorophormic acid derivative and something similar or simply get OXYMORPHONE somehow we still didn+t figured out how!
If Reaction is more than 90-95% sucesseful separating unreacted molecules would not be problem due the naltrexons oopposite/contradictory effect in smaler dosages OR it could be simply separated by column cromatography untill we learn in which solutions or salts oxymorphone has very different solubility than it's eviil brother hasn or even reacts with substrate!
For now,I will mention OsO4 or it's catalystic complex that can with certaintly wreack havock on the damn tail,
or maybe CNXs (Cianogen Halides,like CNF or more common CNBr,depending which one of these will have most accurate effect.
how about oxygenators that need some kind of activator like KOCl4 or similar Boron compound I forgot how its called!
Maybe some of numerous Nitrogen oxides,some of them must be selective enough to desropt hightension/eten-like shit!
Some rare metal catalysts or their compounds,maybe too !?
Purely theoretical reasoning:
in acetonitrile solution, gold(III) chloride (1%) catalyses the alkylation of N-cyclopropylmethy + 2-methylfuran (sylvan) by methyl vinyl ketone at the 5-position in 40 minutes @ 20'C with 91% yield.
How about bubbling O3 + OsO4 through happily stirring tetrahydrofuran with gold chloride (with or without carbon support) with maybe some cooling applied? 3 C4H8O + 2 O3 => 3 C4H6O2 + 3 H2O .. or would the ozone just render the gold useless (Gold is dissolved in O3/Cl-/H+ with formation of AuCl4-) - or even more coordinating.
Please do not talk about the possible peroxide formation...
