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2021-10-12 at 2:17 PM UTC
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2021-10-12 at 2:27 PM UTC
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2021-10-12 at 8:53 PM UTCFully Vaccinated With Pfizer? You’re 6 to 13 Times More Likely to Get Delta Than Someone With Natural Immunity, Study Says
In the largest real-world observational study comparing natural immunity gained through previous SARS-CoV-2 infection to vaccine-induced immunity afforded by the Pfizer mRNA vaccine, people who recovered from COVID were much less likely than never-infected, vaccinated people to get Delta, develop symptoms or be hospitalized.
The study, published Aug. 25 on medRxiv, was conducted in one of the most highly vaccinated countries in the world using data from Maccabi Healthcare Services, which enrolls about 2.5 million Israelis, or about 26% of the population.
Researchers examined medical records of 673,676 Israelis 16 years and older — charting their infections, symptoms and hospitalizations between June 1 and Aug. 14, when the Delta variant predominated in Israel.
The study, led by Tal Patalon and Sivan Gazit, with Maccabi’s research and innovation arm, KSM, found in two analyses that people who had never been infected with SARS-CoV-2 but were vaccinated in January and February were six to 13 times more likely to experience breakthrough infection with the Delta variant compared to unvaccinated people who were previously infected with SARS-CoV-2.
https://childrenshealthdefense.org/defender/fully-vaccinated-pfizer-more-likely-get-delta-than-natural-immunity
https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1The following users say it would be alright if the author of this post didn't die in a fire! -
2021-10-14 at 3:56 PM UTCThe New York Times
Newly Discovered Bat Viruses Give Hints to Covid’s Origins
Carl Zimmer
In the summer of 2020, half a year into the coronavirus pandemic, scientists traveled into the forests of northern Laos to catch bats that might harbor close cousins of the pathogen.
In the dead of night, they used mist nets and canvas traps to snag the animals as they emerged from nearby caves, gathered samples of saliva, urine and feces, then released them back into the darkness.
The fecal samples turned out to contain coronaviruses, which the scientists studied in high security biosafety labs, known as BSL-3, using specialized protective gear and air enhancements.
Three of the Laos coronaviruses were unusual: They carried a molecular hook on their surface that was very similar to the hook on the virus that causes Covid-19, called SARS-CoV-2. Like SARS-CoV-2, their hook allowed them to latch onto human cells.
“It is even better than early strains of SARS-CoV-2,” said Marc Eloit, a virologist at the Pasteur Institute in Paris who led the study, referring to how well the hook on the Laos coronaviruses binds to human cells. The study was posted online last month and has not yet been published in a scientific journal.
Virus experts are buzzing about the discovery. Some suspect that these SARS-CoV-2-like viruses may already be infecting people from time to time, causing only mild and limited outbreaks. But under the right circumstances, the pathogens could give rise to a Covid-19-like pandemic, they say.
The findings also have significant implications for the charged debate over Covid’s origins, experts say. Some people have speculated that SARS-CoV-2’s impressive ability to infect human cells could not have evolved through a natural spillover from an animal. But the new findings seem to suggest otherwise.
“That really puts to bed any notion that this virus had to have been concocted, or somehow manipulated in a lab, to be so good at infecting humans,” said Michael Worobey, a University of Arizona virologist who was not involved in the work.
These bat viruses, along with more than a dozen others discovered in recent months in Laos, Cambodia, China and Thailand, may also help researchers better anticipate future pandemics. The viruses’ family trees offer hints about where potentially dangerous strains are lurking, and which animals scientists should look at to find them.
Last week, the U.S. government announced a $125 million project to identify thousands of wild viruses in Asia, Latin America and Africa to determine their risk of spillover. Dr. Eloit predicted that there were many more relatives of SARS-CoV-2 left to find.
“I am a fly fisherman,” he said. “When I am unable to catch a trout, that doesn’t mean there are no trout in the river.”
When SARS-CoV-2 first came to light, its closest known relative was a bat coronavirus that Chinese researchers found in 2016 in a mine in southern China’s Yunnan Province. RaTG13, as it is known, shares 96 percent of its genome with SARS-CoV-2. Based on the mutations carried by each virus, scientists have estimated that RaTG13 and SARS-CoV-2 share a common ancestor that infected bats about 40 years ago.
Both viruses infect cells by using a molecular hook, called the “receptor-binding domain,” to latch on to their surface. RaTG13’s hook, adapted for attaching to bat cells, can only cling weakly to human cells. SARS-CoV-2’s hook, by contrast, can clasp cells in the human airway, the first step toward a potentially lethal case of Covid-19.
To find other close relatives of SARS-CoV-2, wildlife virus experts checked their freezers full of old samples from across the world. They identified several similar coronaviruses from southern China, Cambodia, and Thailand. Most came from bats, while a few came from scaly mammals known as pangolins. None was a closer relative than RaTG13.
Dr. Eloit and his colleagues instead set out to find new coronaviruses.
They traveled to northern Laos, about 150 miles from the mine where Chinese researchers had found RaTG13. Over six months they caught 645 bats, belonging to 45 different species. The bats harbored two dozen kinds of coronaviruses, three of which were strikingly similar to SARS-CoV-2 — especially in the receptor-binding domain.
In RaTG13, 11 of the 17 key building blocks of the domain are identical to those of SARS-CoV-2. But in the three viruses from Laos, as many as 16 were identical — the closest match to date.
Dr. Eloit speculated that one or more of the coronaviruses might be able to infect humans and cause mild disease. In a separate study, he and colleagues took blood samples from people in Laos who collect bat guano for a living. Although the Laotians did not show signs of having been infected with SARS-CoV-2, they carried immune markers, called antibodies, that appeared to be caused by a similar virus.
Linfa Wang, a molecular virologist at the Duke-NUS Medical School in Singapore who was not involved in the study, agreed that such an infection was possible, since the newly discovered viruses can attach tightly to a protein on human cells called ACE2.
“If the receptor binding domain is ready to use ACE2, these guys are dangerous,” Dr. Wang said.
Paradoxically, some other genes in the three Laotian viruses are more distantly related to SARS-CoV-2 than other bat viruses. The cause of this genetic patchwork is the complex evolution of coronaviruses.
If a bat infected with one coronaviruses catches a second one, the two different viruses may end up in a single cell at once. As that cell begins to replicate each of those viruses, their genes get shuffled together, producing new virus hybrids.
In the Laotian coronaviruses, this gene shuffling has given them a receptor-binding domain that’s very similar to that of SARS-CoV-2. The original genetic swap took place about a decade ago, according to a preliminary analysis by Spyros Lytras, a graduate student at the University of Glasgow in Scotland.
Mr. Lytras and his colleagues are now comparing SARS-CoV-2 not just to the new viruses from Laos, but to other close relatives that have been found in recent months. They’re finding even more evidence of gene shuffling. This process — known as recombination — may be reshaping the viruses from year to year.
“It’s becoming more and more obvious how important recombination is,” Mr. Lytras said.
He and his colleagues are now drawing the messy evolutionary trees of SARS-CoV-2-like viruses based on these new insights. Finding more viruses could help clear up the picture. But scientists are divided as to where to look for them.
Dr. Eloit believes the best bet is a zone of Southeast Asia that includes the site where his colleagues found their coronaviruses, as well as the nearby mine in Yunnan where RaTG13 was found.
“I think the main landscape corresponds to north Vietnam, north Laos and south China,” Dr. Eloit said.
The U.S. government’s new virus-hunting project, called DEEP VZN, may turn up one or more SARS-CoV-2-like viruses in that region. A spokesman for USAID, the agency funding the effort, named Vietnam as one of the countries where researchers will be searching, and said that new coronaviruses are one of their top priorities.
Other scientists think it’s worth looking for relatives of SARS-CoV-2 further afield. Dr. Worobey of the University of Arizona said that some bat coronaviruses carrying SARS-CoV-2-like segments have been found in eastern China and Thailand.
“Clearly the recombination is showing us that these viruses are part of a single gene pool over hundreds and hundreds of miles, if not thousands of miles,” Dr. Worobey said.
Colin Carlson, a biologist at Georgetown University, suspects that a virus capable of producing a Covid-like outbreak might be lurking even further away. Bats as far east as Indonesia and as far west as India, he noted, share many biological features with the animals known to carry SARS-CoV-2-like viruses.
“This is not just a Southeast Asia problem,” Dr. Carlson said. “These viruses are diverse, and they are more cosmopolitan than we have thought.”
The interest in the origins of the pandemic has put renewed attention on the safety measures researchers are using when studying potentially dangerous viruses. To win DEEP VZN grants, scientists will have to provide a biosafety and biosecurity plan, according to a USAID spokesman, including training for staff, guidelines on protective equipment to be worn in the field and safety measures for lab work.
If scientists find more close cousins of SARS-CoV-2, it doesn’t necessarily mean they pose a deadly threat. They might fail to spread in humans or, as some scientists speculate, cause only small outbreaks. Just seven coronaviruses are known to have jumped the species barrier to become well-established human pathogens.
“There’s probably a vast range of other coronaviruses that end up going nowhere,” said Jessica Metcalf, an evolutionary ecologist at Princeton University.
Still, recombination may be able to turn a virus going nowhere into a new threat. In May, researchers reported that two coronaviruses in dogs recombined in Indonesia. The result was a hybrid that infected eight children.
“When a coronavirus that we have monitored for decades, that we think of as just something our pets can get, can make the jump — we should have seen that coming, right?” Dr. Carlson said. -
2021-10-16 at 8:41 PM UTCLatest UKHSA report shows Vaccinated accounted for 80% of Covid-19 Deaths and 60% of Hospitalisations in the last 4 weeks.
Read all about here.
https://theexpose.uk/2021/10/16/latest-ukhsa-report-80-percent-covid-deaths-vaccinated/The following users say it would be alright if the author of this post didn't die in a fire! -
2021-10-16 at 10:01 PM UTCThey're deliberately killing millions with the shots. Global depopulation. Right out in the open. Right in your face.The following users say it would be alright if the author of this post didn't die in a fire!
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2021-10-16 at 10:15 PM UTCCheck this out.
The following users say it would be alright if the author of this post didn't die in a fire! -
2021-10-16 at 10:52 PM UTC
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2021-10-16 at 10:58 PM UTCI'm not afraid of looking like a retard but wtf? are you talking about?
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2021-10-16 at 11:08 PM UTC
Originally posted by AngryOnion I'm not afraid of looking like a retard but wtf? are you talking about?
The two columns omitted refer to cases per 100,000 for each population group (unvaccinated and vaccinated). The article completely misconstrues the report.
There are already enough reasonable arguments for not being vaccinated, without the distraction of easily refutable bullshit. -
2021-10-17 at 12:22 AM UTCOK then if I'm wrong then I will admit it.
See getting trolled is a two way street. -
2021-10-17 at 6:18 AM UTCI like the song Wango Tango and Strangle Hold. I blare it through Berkeley getting dirty looks from most people. they hate that dude so much here. But I like music so I don't fucking care.
But Ted Nugent is kind of a redneck -
2021-10-17 at 6:28 AM UTC
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2021-10-17 at 7:55 AM UTC
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2021-10-17 at 8:58 AM UTC
Originally posted by ⠀⠀⠀⠀⠀⠀ Fully Vaccinated With Pfizer? You’re 6 to 13 Times More Likely to Get Delta Than Someone With Natural Immunity, Study Says
In the largest real-world observational study comparing natural immunity gained through previous SARS-CoV-2 infection to vaccine-induced immunity afforded by the Pfizer mRNA vaccine, people who recovered from COVID were much less likely than never-infected, vaccinated people to get Delta, develop symptoms or be hospitalized.
The study, published Aug. 25 on medRxiv, was conducted in one of the most highly vaccinated countries in the world using data from Maccabi Healthcare Services, which enrolls about 2.5 million Israelis, or about 26% of the population.
Researchers examined medical records of 673,676 Israelis 16 years and older — charting their infections, symptoms and hospitalizations between June 1 and Aug. 14, when the Delta variant predominated in Israel.
The study, led by Tal Patalon and Sivan Gazit, with Maccabi’s research and innovation arm, KSM, found in two analyses that people who had never been infected with SARS-CoV-2 but were vaccinated in January and February were six to 13 times more likely to experience breakthrough infection with the Delta variant compared to unvaccinated people who were previously infected with SARS-CoV-2.
https://childrenshealthdefense.org/defender/fully-vaccinated-pfizer-more-likely-get-delta-than-natural-immunity
https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1
sounds fake to me but so does everything these days. the tard flu -
2021-10-17 at 2:51 PM UTC
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2021-10-17 at 7:47 PM UTCRESTLESS ASS SYNDROME - Finally, the excuse you need to get your jab!
Good Housekeeping
Experts Explain Why 'Deep a*** Discomfort' May Be an Overlooked COVID-19 Symptom
Zee Krstic
Here's what experts know about how COVID-19 causes severe digestive symptoms, including new side effects associated with 'Restless a*** Syndrome.'© Carol Yepes - Getty Images Here's what experts know about how COVID-19 causes severe digestive symptoms, including new side effects associated with 'Restless a*** Syndrome.'
A new case report published in Japan has established a potential link between COVID-19 and what experts are calling "Restless a*** Syndrome."
The singular 77-year-old patient developed chronic gastrointestinal pain that experts describe as a constant urge to defecate.
More research is needed to determine a link between the new syndrome and COVID-19, but experts say that GI discomfort may be an overlooked symptom associated with long-lasting COVID-19 side effects.
While the virus that spreads COVID-19 has mutated into more viral variants, the symptoms associated with the disease have largely remained the same — but a new report out of Japan has experts revisiting the severity of potential side effects now that the Delta variant is the most common worldwide. Limited evidence may suggest that certain kinds of symptoms may be exacerbated by newer strains of the disease after specialists in Japan shared the story of a 77-year-old man who developed what they now refer to as "Restless a*** Syndrome."
As detailed in a case report published by BMC Infectious Diseases in late September, the elderly man is believed to be the first to have developed this particular set of symptoms after initially recovering from his COVID-19 infection. Authors of the report indicate that a case of this kind — which began after the man spent three weeks in the hospital being treated for COVID-19 — has yet to be studied in-depth, and that data is extremely limited to establish a better understanding of what occurred.
Charles Bailey, M.D., the medical director of infection prevention at Providence St. Joseph Hospital, says that COVID-19 symptoms have shifted slightly since the beginning of the pandemic. But as gastrointestinal distress and irregularity have been well-documented as symptoms of a COVID-19 infection, experts are keen to learn more about this particular diagnosis, which could affect more patients in different forms than is currently realized.
What is Restless a*** Syndrome?
The patient treated by experts at Tokyo Medical University Hospital turned to doctors well after his initial COVID-19 infection, when he began feeling what's been described as a constant urge to defecate.
"Several weeks after discharge, he gradually began to experience restless, deep a*** discomfort," the study's authors wrote, adding that the man rarely felt relieved even after a trip to the restroom. The urge to run for the bathroom was worse for the man when he slept at night and when he was resting throughout most of the day. Only when he was moving or breaking a sweat did he feel temporary relief before the sensation rushed back later, the authors noted.
In investigating his symptoms, experts conducted colonoscopies and neurological tests for reflexes in the man's a***, but neither could explain why these symptoms arose weeks after his infection. While hemorrhoids were found, experts also didn't detect that there were any sensory issues or a spinal cord injury.
The study's authors indicated that Restless a*** Syndrome appeared to impact the body in the same way as Restless Legs Syndrome (RLS), linking it to COVID-19 as more evidence indicates that the disease can impact the central nervous system.
Eventually, the man was prescribed a daily dose of Clonazepam, which has also been used to treat RLS — sadly, the authors noted that it alleviated some discomfort but didn't solve it outright. While much more research must be done to fully understand this case and a further potential link to COVID-19, because gastrointestinal COVID-19 symptoms have long been established, the study's authors warn that the condition may be overlooked currently. "COVID-19 related RLS or RLS-variant may be underdiagnosed and we should pay attention to similar cases in order to clarify the relation between COVID-19 and RLS," the report reads.
Other digestive symptoms associated with COVID-19:
More evidence is needed to effectively deduce if Restless a*** Syndrome can be attributed to COVID-19, but healthcare officials have indicated that gastrointestinal side effects can be active symptoms — even though the disease is respiratory in nature.
Officials at the Centers for Disease Control and Prevention (CDC) have indicated that there are 11 symptoms currently associated with a COVID-19 infection, but indicate that others may potentially experience unique symptoms as well. The main gastrointestinal issues that could impact you during a sickness include:
Experts also know that COVID-19 impacts our GI tract because they've been able to trace virus in stool samples as well as biopsy samples, Dr. Bailey explains. "This aligns with observed clinical complications like elevated liver enzymes, or liver inflammation; ileus, or slow bowel motility; and bowel ischemia, which is poor blood flow to intestines resulting in pain, potential bowel perforation, or sepsis," he adds."[Doctors] have also seen gallbladder inflammation without gallstones, and pancreatic inflammation."
Because COVID-19 is still a relatively new disease, experts have yet to determine why exactly it impacts one's gastrointestinal system. But Dr. Bailey says GI issues and side effects remain less common than respiratory symptoms like fever, cough and shortness of breath. Healthcare providers do actively check for any GI issues when treating someone who contracted COVID-19 — but just as the Restless a*** Syndrome report indicated, doctors like Dr. Bailey aren't sure if GI issues arise directly due to COVID virus or because COVID-19 interrupts the blood flow to the smallest vessels inside the intestines, for example.
The bottom line is much more research is needed to fully understand Restless a*** Syndrome, and its relevance is likely extremely low on a global scale. But experts stress that it's more important to monitor GI issues as potential symptoms for COVID-19 infection. Consult your primary healthcare provider if you notice that you're experiencing the gastrointestinal symptoms above and can't trace it back to causes; it may be time to get tested for COVID-19.
GET YOUR JAB TODAY...BEFORE YOU HAVE TO BUY ADULT DIAPERS TOMORROW!
NO SHIT!! -
2021-10-17 at 7:51 PM UTCexperts lol
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2021-10-17 at 7:54 PM UTCAs full of shit as you are, Shlomo, you could die on the toilet...just like Elvis.
