How to make 5 kilos of morphine from a 1 meter patch of poppies

1. 2019-04-26 at 4:40 PM UTC

   #1
   

   Ghost Black Hole
   So way back in the 1970s in the grand ol' USA, Richard Nixon was concerned about domestic production of heroin, and proposed replacing the common oriental garden poppy with Papaver bracteatum. Bracteatum is a perennial which produces equally beautiful flowers, but contains no psychoactive codeine or morphine. Government scientists shot down the idea, fearing that Bentley compounds, synthetic derivatives of thebaine with potency thousands of times that of heroin, would replace ordinary dope on the street.
   
   The scientists were right: Bracteatum latex is up to 50% thebaine, and rough estimates suggest a square meter garden patch of Papaver bracteatum would yield roughly 6 grams of pure thebaine once processed.
   In Narcotic Analgesics and Antagonists; Lewis, Bentley and Cowan 1971, the simple cyclohexene diels-alder adduct of oripavine (o-demethylated thebaine) is reported to be 1000x the strength of morphine.
   
   https://en.wikipedia.org/wiki/Oripavine
   
   What does this mean? Simply heat thebaine with cyclohexene, then demethylate (or don't, though the ether is probably 10-50x less potent) with pyridine hydrochloride or similar to yield an opiate some 1000x the potency of morphine. On par with 3-methylfentanyl, and with the favorable pharmacological properties of the Bentley compounds, including relatively high therapeutic index and euphoria compared to fentanyls.
   
   A meter garden patch, after conversion and assuming reasonable yields, would give about 5g of product. Once diluted this is equivalent to nearly 5 kilos of pure morphine.
   The following users say it would be alright if the author of this post didn't die in a fire!

   • y36mg
2. 2019-04-29 at 5:40 PM UTC

   #2
   We'reAllBrownNosers African Astronaut
   Cool thread, didn't know this. I know a drug nerd that would be interested in this probably.
   
   
   EDIT: misleading title, although potentially a great way for terrorists to kill shitloads of people
3. 2019-05-04 at 9:45 PM UTC

   #3
   

   STER0S Space Nigga [the disappointingly unanticipated slab]
   what's morphine
4. 2019-05-04 at 11:37 PM UTC

   #4
   The Self Taught Man Black Hole

   Originally posted by STER0S what's morphine

   
   More like a 5 dollar DICKphene
5. 2019-05-05 at 12:41 AM UTC

   #5
   

   mashlehash victim of incest [my perspicuously dependant flavourlessness]

   Originally posted by Ghost So way back in the 1970s in the grand ol' USA, Richard Nixon was concerned about domestic production of heroin, and proposed replacing the common oriental garden poppy with Papaver bracteatum. Bracteatum is a perennial which produces equally beautiful flowers, but contains no psychoactive codeine or morphine. Government scientists shot down the idea, fearing that Bentley compounds, synthetic derivatives of thebaine with potency thousands of times that of heroin, would replace ordinary dope on the street.
   
   The scientists were right: Bracteatum latex is up to 50% thebaine, and rough estimates suggest a square meter garden patch of Papaver bracteatum would yield roughly 6 grams of pure thebaine once processed.
   In Narcotic Analgesics and Antagonists; Lewis, Bentley and Cowan 1971, the simple cyclohexene diels-alder adduct of oripavine (o-demethylated thebaine) is reported to be 1000x the strength of morphine.
   
   https://en.wikipedia.org/wiki/Oripavine
   
   What does this mean? Simply heat thebaine with cyclohexene, then demethylate (or don't, though the ether is probably 10-50x less potent) with pyridine hydrochloride or similar to yield an opiate some 1000x the potency of morphine. On par with 3-methylfentanyl, and with the favorable pharmacological properties of the Bentley compounds, including relatively high therapeutic index and euphoria compared to fentanyls.
   
   A meter garden patch, after conversion and assuming reasonable yields, would give about 5g of product. Once diluted this is equivalent to nearly 5 kilos of pure morphine.

   
   Mm good read